4.0
Summary
| Name |  GLSView Modifications |
| Full Name | Glutaminase kidney isoform, mitochondrial |
| Synonyms | GLS, K-glutaminase, L-glutamine amidohydrolase | GLS1, KIAA0838 |
| Primary ID | O94925 |
| Links |  -  -  |
| Type | protein |
| Relations | 10 |
| Pathways | Glutamine metabolism |
| Function | Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain (PubMed:30575854, PubMed:30239721, PubMed:30970188). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCE | up-regulates activity 
phosphorylation
|
GLS | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MYC | up-regulates quantity by expression 
transcriptional regulation
|
GLS | 0.442 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GLS | up-regulates quantity
chemical modification
|
L-glutamate(1-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Glutamine metabolism | |||
| + | GLS | up-regulates activity
|
Glutaminolysis | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SIRT5 | up-regulates activity
binding
|
GLS | 0.448 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PPARG | down-regulates quantity by repression 
transcriptional regulation
|
GLS | 0.247 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | JUN | up-regulates quantity by expression
transcriptional regulation
|
GLS | 0.351 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | miR-23a | down-regulates quantity 
post transcriptional regulation
|
GLS | 0.4 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | miR-23b | down-regulates quantity
post transcriptional regulation
|
GLS | 0.4 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | GLS | down-regulates quantity
chemical modification
|
L-glutamine zwitterion | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Glutamine metabolism | |||