| + |
AURKB | up-regulates activity 
phosphorylation
|
ZWINT |
0.639 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265009 |
Ser250 |
PTRPQEQsTGDTMGR |
in vitro |
|
| pmid |
sentence |
| 21775627 |
Zwint-1 is a novel Aurora B substrate required for the assembly of a dynein-binding platform on kinetochores|During prometaphase, AurB phosphorylation of zwint-1 is required for recruitment of ZW10-, pT89 dynein-, and RZZ-dependent proteins to kinetochores. This is defective after AurB inhibition or after expression of the triple-A zwint-1 mutant. Triple-E mutant zwint-1 mimics phospho–zwint-1 in RZZ recruitment, even after AurB inhibition |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265011 |
Ser262 |
MGRDPGVsFKAVGLQ |
in vitro |
|
| pmid |
sentence |
| 21775627 |
Zwint-1 is a novel Aurora B substrate required for the assembly of a dynein-binding platform on kinetochores|During prometaphase, AurB phosphorylation of zwint-1 is required for recruitment of ZW10-, pT89 dynein-, and RZZ-dependent proteins to kinetochores. This is defective after AurB inhibition or after expression of the triple-A zwint-1 mutant. Triple-E mutant zwint-1 mimics phospho–zwint-1 in RZZ recruitment, even after AurB inhibition |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265010 |
Thr251 |
TRPQEQStGDTMGRD |
in vitro |
|
| pmid |
sentence |
| 21775627 |
Zwint-1 is a novel Aurora B substrate required for the assembly of a dynein-binding platform on kinetochores|During prometaphase, AurB phosphorylation of zwint-1 is required for recruitment of ZW10-, pT89 dynein-, and RZZ-dependent proteins to kinetochores. This is defective after AurB inhibition or after expression of the triple-A zwint-1 mutant. Triple-E mutant zwint-1 mimics phospho–zwint-1 in RZZ recruitment, even after AurB inhibition |
|
| Publications: |
3 |
Organism: |
In Vitro |
| + |
BECN1 | up-regulates activity
binding
|
ZWINT |
0.449 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265027 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 23478334 |
We show that Beclin-1 interacts directly with Zwint-1-a component of the KMN (KNL-1/Mis12/Ndc80) complex-which is essential for kinetochore-microtubule interactions. This suggests that Beclin-1 acts downstream of the KMN complex to influence the recruitment of outer kinetochore proteins and promotes accurate kinetochore anchoring to the spindle during mitosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZWINT | form complex 
binding
|
KNL1 complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265194 |
|
|
|
|
| pmid |
sentence |
| 27881301 |
KNL1C (known as Spc105 complex in S. cerevisiae) contains the KNL1 and ZWINT subunits. |
|
| Publications: |
1 |
| + |
ZWINT | form complex
binding
|
RZZ complex |
0.64 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265013 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20462495 |
The RZZ complex recruits dynein to kinetochores. We investigated structure, topology, and interactions of the RZZ subunits (ROD, ZWILCH, and ZW10) in vitro, in vivo, and in silico. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ZWINT
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- 