| + |
CDK11A | down-regulates quantity by destabilization 
phosphorylation
|
SPDEF |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273020 |
Ser238 |
SEESWTDsEVDSSCS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26885618 |
In this study we provide evidence that the cell cycle kinase CDK11p58, a protein involved in G2/M transition and degradation of several transcription factors, directly interacts with and phosphorylates SPDEF on serine residues|Western blot analysis demonstrated that only one of the mutant constructs, consisting of mutations of serine 238, 242 and 243, resulted in increased levels of SPDEF protein expression as compared to wild type SPDEF, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway.| |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273021 |
Ser242 |
WTDSEVDsSCSGQPI |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26885618 |
In this study we provide evidence that the cell cycle kinase CDK11p58, a protein involved in G2/M transition and degradation of several transcription factors, directly interacts with and phosphorylates SPDEF on serine residues|Western blot analysis demonstrated that only one of the mutant constructs, consisting of mutations of serine 238, 242 and 243, resulted in increased levels of SPDEF protein expression as compared to wild type SPDEF, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway.| |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273022 |
Ser243 |
TDSEVDSsCSGQPIH |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26885618 |
In this study we provide evidence that the cell cycle kinase CDK11p58, a protein involved in G2/M transition and degradation of several transcription factors, directly interacts with and phosphorylates SPDEF on serine residues|Western blot analysis demonstrated that only one of the mutant constructs, consisting of mutations of serine 238, 242 and 243, resulted in increased levels of SPDEF protein expression as compared to wild type SPDEF, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway.| |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CyclinD3/CDK11B | down-regulates quantity by destabilization
phosphorylation
|
SPDEF |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273126 |
Ser238 |
SEESWTDsEVDSSCS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26885618 |
In this study we provide evidence that the cell cycle kinase CDK11p58, a protein involved in G2/M transition and degradation of several transcription factors, directly interacts with and phosphorylates SPDEF on serine residues|Western blot analysis demonstrated that only one of the mutant constructs, consisting of mutations of serine 238, 242 and 243, resulted in increased levels of SPDEF protein expression as compared to wild type SPDEF, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway.| |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273127 |
Ser242 |
WTDSEVDsSCSGQPI |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26885618 |
In this study we provide evidence that the cell cycle kinase CDK11p58, a protein involved in G2/M transition and degradation of several transcription factors, directly interacts with and phosphorylates SPDEF on serine residues|Western blot analysis demonstrated that only one of the mutant constructs, consisting of mutations of serine 238, 242 and 243, resulted in increased levels of SPDEF protein expression as compared to wild type SPDEF, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway.| |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273128 |
Ser243 |
TDSEVDSsCSGQPIH |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26885618 |
In this study we provide evidence that the cell cycle kinase CDK11p58, a protein involved in G2/M transition and degradation of several transcription factors, directly interacts with and phosphorylates SPDEF on serine residues|Western blot analysis demonstrated that only one of the mutant constructs, consisting of mutations of serine 238, 242 and 243, resulted in increased levels of SPDEF protein expression as compared to wild type SPDEF, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway.| |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CyclinD3/CDK11A | down-regulates quantity by destabilization
phosphorylation
|
SPDEF |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273121 |
Ser238 |
SEESWTDsEVDSSCS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26885618 |
In this study we provide evidence that the cell cycle kinase CDK11p58, a protein involved in G2/M transition and degradation of several transcription factors, directly interacts with and phosphorylates SPDEF on serine residues|Western blot analysis demonstrated that only one of the mutant constructs, consisting of mutations of serine 238, 242 and 243, resulted in increased levels of SPDEF protein expression as compared to wild type SPDEF, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway.| |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273122 |
Ser242 |
WTDSEVDsSCSGQPI |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26885618 |
In this study we provide evidence that the cell cycle kinase CDK11p58, a protein involved in G2/M transition and degradation of several transcription factors, directly interacts with and phosphorylates SPDEF on serine residues|Western blot analysis demonstrated that only one of the mutant constructs, consisting of mutations of serine 238, 242 and 243, resulted in increased levels of SPDEF protein expression as compared to wild type SPDEF, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway.| |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273123 |
Ser243 |
TDSEVDSsCSGQPIH |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26885618 |
In this study we provide evidence that the cell cycle kinase CDK11p58, a protein involved in G2/M transition and degradation of several transcription factors, directly interacts with and phosphorylates SPDEF on serine residues|Western blot analysis demonstrated that only one of the mutant constructs, consisting of mutations of serine 238, 242 and 243, resulted in increased levels of SPDEF protein expression as compared to wild type SPDEF, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway.| |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
SPDEF | down-regulates quantity by repression 
transcriptional regulation
|
MMP13 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255219 |
|
|
Homo sapiens |
PrEC Cell |
| pmid |
sentence |
| 22761428 |
Transcriptional analysis of several genes associated with tumor metastasis, invasion, and the epithelial-mesenchymal transition demonstrated that SPDEF expression selectively down-regulated MMP9 and MMP13 in prostate cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPDEF | down-regulates quantity by repression
transcriptional regulation
|
MMP9 |
0.369 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255218 |
|
|
Homo sapiens |
PrEC Cell |
| pmid |
sentence |
| 22761428 |
Transcriptional analysis of several genes associated with tumor metastasis, invasion, and the epithelial-mesenchymal transition demonstrated that SPDEF expression selectively down-regulated MMP9 and MMP13 in prostate cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SPDEF
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