Relation Results

Summary

Name SPDEF
Full Name SAM pointed domain-containing Ets transcription factor
Synonyms Prostate epithelium-specific Ets transcription factor, Prostate-specific Ets, Prostate-derived Ets factor | PDEF, PSE
Primary ID O95238
Links - -
Type protein
Relations 11
Function May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a ...
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Type: Score: Layout: SPV 
0.3580.3580.3580.20.363CDK11ASPDEFCyclinD3/CDK11ACyclinD3/CDK11BMMP13MMP9

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CDK11Adown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SPDEF 0.358
Identifier Residue Sequence Organism Cell Line
SIGNOR-273020 Ser238 SEESWTDsEVDSSCS Homo sapiens HEK-293 Cell
pmid sentence
In this study we provide evidence that the cell cycle kinase CDK11p58, a protein involved in G2/M transition and degradation of several transcription factors, directly interacts with and phosphorylates SPDEF on serine residues|Western blot analysis demonstrated that only one of the mutant constructs, consisting of mutations of serine 238, 242 and 243, resulted in increased levels of SPDEF protein expression as compared to wild type SPDEF, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway.|
Identifier Residue Sequence Organism Cell Line
SIGNOR-273021 Ser242 WTDSEVDsSCSGQPI Homo sapiens HEK-293 Cell
pmid sentence
In this study we provide evidence that the cell cycle kinase CDK11p58, a protein involved in G2/M transition and degradation of several transcription factors, directly interacts with and phosphorylates SPDEF on serine residues|Western blot analysis demonstrated that only one of the mutant constructs, consisting of mutations of serine 238, 242 and 243, resulted in increased levels of SPDEF protein expression as compared to wild type SPDEF, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway.|
Identifier Residue Sequence Organism Cell Line
SIGNOR-273022 Ser243 TDSEVDSsCSGQPIH Homo sapiens HEK-293 Cell
pmid sentence
In this study we provide evidence that the cell cycle kinase CDK11p58, a protein involved in G2/M transition and degradation of several transcription factors, directly interacts with and phosphorylates SPDEF on serine residues|Western blot analysis demonstrated that only one of the mutant constructs, consisting of mutations of serine 238, 242 and 243, resulted in increased levels of SPDEF protein expression as compared to wild type SPDEF, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway.|
Publications: 3 Organism: Homo Sapiens
+ CyclinD3/CDK11Adown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SPDEF 0.358
Identifier Residue Sequence Organism Cell Line
SIGNOR-273121 Ser238 SEESWTDsEVDSSCS Homo sapiens HEK-293 Cell
pmid sentence
In this study we provide evidence that the cell cycle kinase CDK11p58, a protein involved in G2/M transition and degradation of several transcription factors, directly interacts with and phosphorylates SPDEF on serine residues|Western blot analysis demonstrated that only one of the mutant constructs, consisting of mutations of serine 238, 242 and 243, resulted in increased levels of SPDEF protein expression as compared to wild type SPDEF, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway.|
Identifier Residue Sequence Organism Cell Line
SIGNOR-273122 Ser242 WTDSEVDsSCSGQPI Homo sapiens HEK-293 Cell
pmid sentence
In this study we provide evidence that the cell cycle kinase CDK11p58, a protein involved in G2/M transition and degradation of several transcription factors, directly interacts with and phosphorylates SPDEF on serine residues|Western blot analysis demonstrated that only one of the mutant constructs, consisting of mutations of serine 238, 242 and 243, resulted in increased levels of SPDEF protein expression as compared to wild type SPDEF, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway.|
Identifier Residue Sequence Organism Cell Line
SIGNOR-273123 Ser243 TDSEVDSsCSGQPIH Homo sapiens HEK-293 Cell
pmid sentence
In this study we provide evidence that the cell cycle kinase CDK11p58, a protein involved in G2/M transition and degradation of several transcription factors, directly interacts with and phosphorylates SPDEF on serine residues|Western blot analysis demonstrated that only one of the mutant constructs, consisting of mutations of serine 238, 242 and 243, resulted in increased levels of SPDEF protein expression as compared to wild type SPDEF, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway.|
Publications: 3 Organism: Homo Sapiens
+ CyclinD3/CDK11Bdown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SPDEF 0.358
Identifier Residue Sequence Organism Cell Line
SIGNOR-273126 Ser238 SEESWTDsEVDSSCS Homo sapiens HEK-293 Cell
pmid sentence
In this study we provide evidence that the cell cycle kinase CDK11p58, a protein involved in G2/M transition and degradation of several transcription factors, directly interacts with and phosphorylates SPDEF on serine residues|Western blot analysis demonstrated that only one of the mutant constructs, consisting of mutations of serine 238, 242 and 243, resulted in increased levels of SPDEF protein expression as compared to wild type SPDEF, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway.|
Identifier Residue Sequence Organism Cell Line
SIGNOR-273127 Ser242 WTDSEVDsSCSGQPI Homo sapiens HEK-293 Cell
pmid sentence
In this study we provide evidence that the cell cycle kinase CDK11p58, a protein involved in G2/M transition and degradation of several transcription factors, directly interacts with and phosphorylates SPDEF on serine residues|Western blot analysis demonstrated that only one of the mutant constructs, consisting of mutations of serine 238, 242 and 243, resulted in increased levels of SPDEF protein expression as compared to wild type SPDEF, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway.|
Identifier Residue Sequence Organism Cell Line
SIGNOR-273128 Ser243 TDSEVDSsCSGQPIH Homo sapiens HEK-293 Cell
pmid sentence
In this study we provide evidence that the cell cycle kinase CDK11p58, a protein involved in G2/M transition and degradation of several transcription factors, directly interacts with and phosphorylates SPDEF on serine residues|Western blot analysis demonstrated that only one of the mutant constructs, consisting of mutations of serine 238, 242 and 243, resulted in increased levels of SPDEF protein expression as compared to wild type SPDEF, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway.|
Publications: 3 Organism: Homo Sapiens
+ SPDEFdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MMP13 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-255219 Homo sapiens PrEC Cell
pmid sentence
Transcriptional analysis of several genes associated with tumor metastasis, invasion, and the epithelial-mesenchymal transition demonstrated that SPDEF expression selectively down-regulated MMP9 and MMP13 in prostate cancer cells.
Publications: 1 Organism: Homo Sapiens
+ SPDEFdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MMP9 0.363
Identifier Residue Sequence Organism Cell Line
SIGNOR-255218 Homo sapiens PrEC Cell
pmid sentence
Transcriptional analysis of several genes associated with tumor metastasis, invasion, and the epithelial-mesenchymal transition demonstrated that SPDEF expression selectively down-regulated MMP9 and MMP13 in prostate cancer cells.
Publications: 1 Organism: Homo Sapiens
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