Relation Results

Summary

Name MMP13
Full Name Collagenase 3
Synonyms Matrix metalloproteinase-13, MMP-13 |
Primary ID P45452
Links - -
Type protein
Relations 23
Function Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical colla ...
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Type: Score: Layout: SPV 
0.20.20.3180.5590.20.3560.2540.3140.4830.4020.3760.20.3620.70.70.3310.20.2940.4290.310.4560.393MMP13FGAFGBF12COL2A1FGGBMP7MAFNfKb-p65/p50RUNX2JUNCITED2SPDEFIGF1ECM_disassemblyECMHDAC4YBX1STAT1FGF2ETS1PTHING2

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ MMP13down-regulates quantity by destabilization img/direct_inhibition.png cleavage FGA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263612 Ala20 VVGTAWTaDSGEGDF in vitro
pmid sentence
Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII| We have now investigated the role of collagenase-2 (MMP-8), macrophage elastase (MMP-12), collagenase-3 (MMP-13), and membrane type 1-matrix metalloproteinase (MT1-MMP, MMP-14) in the degradation of fibrinogen and Factor XII of the plasma clotting system.|MMP-13 27YVATRDN g-chain| 20ADSGEGD a-chain| 124RNSVDXLNXN b-chain| 442LRTGKEKV a-chain
Identifier Residue Sequence Organism Cell Line
SIGNOR-263613 Leu442 TSKGDKElRTGKEKV in vitro
pmid sentence
Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII| We have now investigated the role of collagenase-2 (MMP-8), macrophage elastase (MMP-12), collagenase-3 (MMP-13), and membrane type 1-matrix metalloproteinase (MT1-MMP, MMP-14) in the degradation of fibrinogen and Factor XII of the plasma clotting system.|MMP-13 27YVATRDN g-chain| 20ADSGEGD a-chain| 124RNSVDXLNXN b-chain| 442LRTGKEKV a-chain
Publications: 2 Organism: In Vitro
+ MMP13down-regulates quantity by destabilization img/direct_inhibition.png cleavage FGB 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263615 Arg124 LQQERPIrNSVDELN in vitro
pmid sentence
Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII| We have now investigated the role of collagenase-2 (MMP-8), macrophage elastase (MMP-12), collagenase-3 (MMP-13), and membrane type 1-matrix metalloproteinase (MT1-MMP, MMP-14) in the degradation of fibrinogen and Factor XII of the plasma clotting system.|MMP-13 27YVATRDN g-chain| 20ADSGEGD a-chain| 124RNSVDXLNXN b-chain| 442LRTGKEKV a-chain
Publications: 1 Organism: In Vitro
+ MMP13down-regulates quantity by destabilization img/direct_inhibition.png cleavage F12 0.318
Identifier Residue Sequence Organism Cell Line
SIGNOR-263609 Gly376 SMTRVVGgLVALRGA in vitro
pmid sentence
The data presented in this study show for the first time the degradation of Factor XII of the blood clotting system by matrix metalloproteinases. MMP-12, MMP-13, and MMP-14 cleave at Gly376Leu377|However, no activity of Factor XII can be observed after MMPinduced cleavage.
Publications: 1 Organism: In Vitro
+ MMP13down-regulates quantity by destabilization img/direct_inhibition.png cleavage COL2A1 0.559
Identifier Residue Sequence Organism Cell Line
SIGNOR-256340 Gly906 EGPPGPQgLAGQRGI Homo sapiens
pmid sentence
Although it appears that MMP-1 and MMP-13 both cleave type II collagen initially at the same site, MMP-13 affects a secondary cleavage to produce a 1/4-size collagen fragment with an NH2 terminus three amino acids removed from the primary cleavage site.The present work has demonstrated expression of MMP-13 in human osteoarthritic cartilage and shown that MMP-13 has significant type II collagen degrading activity.
Publications: 1 Organism: Homo Sapiens
+ MMP13down-regulates quantity by destabilization img/direct_inhibition.png cleavage FGG 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263614 Tyr27 LSSTCVAyVATRDNC in vitro
pmid sentence
Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII| We have now investigated the role of collagenase-2 (MMP-8), macrophage elastase (MMP-12), collagenase-3 (MMP-13), and membrane type 1-matrix metalloproteinase (MT1-MMP, MMP-14) in the degradation of fibrinogen and Factor XII of the plasma clotting system.|MMP-13 27YVATRDN g-chain| 20ADSGEGD a-chain| 124RNSVDXLNXN b-chain| 442LRTGKEKV a-chain
Publications: 1 Organism: In Vitro
+ BMP7down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MMP13 0.356
Identifier Residue Sequence Organism Cell Line
SIGNOR-254801 Homo sapiens Chondrocyte Cell Line
pmid sentence
In the present study we investigated the inhibitory effects of IGF-1 and OP-1 on MMP-13 expression in human chondrocytes. We found that the suppressive effect of IGF-1 and OP-1 on the MMP-13 promoter activity was dose-dependent at the transcriptional level with a corresponding decrease in the level of MMP-13 protein.
Publications: 1 Organism: Homo Sapiens
+ MAFup-regulates quantity by expression img/indirect-activation.png transcriptional regulation MMP13 0.254
Identifier Residue Sequence Organism Cell Line
SIGNOR-254560 Homo sapiens
pmid sentence
MMP-13 gene expression is regulated primarily at the transcriptional level. In this study, we investigated the role of c-maf in regulating MMP-13 transcription. Using transient transfection system with an c-maf construct, and MMP-13 promoter-luciferase constructs with specific mutations in transcription factor binding sites, we found that c-maf can significantly enhance MMP-13 promoter activity via the AP-1 sitecv
Publications: 1 Organism: Homo Sapiens
+ NfKb-p65/p50up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MMP13 0.314
Identifier Residue Sequence Organism Cell Line
SIGNOR-254800 Homo sapiens Chondrocyte Cell Line
pmid sentence
The suppressive effect of IGF-1 and OP-1 on MMP-13 expression was due in part to down-regulation of the expression of pro-inflammatory cytokines and the activity of their intermediate molecules, including NF-kappaB and AP-1 factors.
Publications: 1 Organism: Homo Sapiens
+ RUNX2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MMP13 0.483
Identifier Residue Sequence Organism Cell Line
SIGNOR-255078 Homo sapiens
pmid sentence
Increased expression of RUNX2 in OA cartilage may contribute to increased expression of MMP-13. FGF2, which is present in OA synovial fluid, activated RUNX2 via the MEK/ERK pathway and increased MMP-13 expression.
Publications: 1 Organism: Homo Sapiens
+ JUNup-regulates quantity by expression img/indirect-activation.png transcriptional regulation MMP13 0.402
Identifier Residue Sequence Organism Cell Line
SIGNOR-254539 Homo sapiens
pmid sentence
The activated c-Jun protein has been proven to activate binding to the MMP-13 promoter and also upregulate the amount of MMP-13.
Publications: 1 Organism: Homo Sapiens
+ CITED2down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MMP13 0.376
Identifier Residue Sequence Organism Cell Line
SIGNOR-253777 Homo sapiens C-28/I2 Cell
pmid sentence
CITED2 plays a major role in shear-induced down-regulation of MMP-1 and MMP-13 via a transforming growth factor-beta-dependent pathway.
Publications: 1 Organism: Homo Sapiens
+ SPDEFdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MMP13 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-255219 Homo sapiens PrEC Cell
pmid sentence
Transcriptional analysis of several genes associated with tumor metastasis, invasion, and the epithelial-mesenchymal transition demonstrated that SPDEF expression selectively down-regulated MMP9 and MMP13 in prostate cancer cells.
Publications: 1 Organism: Homo Sapiens
+ IGF1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MMP13 0.362
Identifier Residue Sequence Organism Cell Line
SIGNOR-254802 Homo sapiens Chondrocyte Cell Line
pmid sentence
In the present study we investigated the inhibitory effects of IGF-1 and OP-1 on MMP-13 expression in human chondrocytes. We found that the suppressive effect of IGF-1 and OP-1 on the MMP-13 promoter activity was dose-dependent at the transcriptional level with a corresponding decrease in the level of MMP-13 protein.
Publications: 1 Organism: Homo Sapiens
+ MMP13up-regulates img/indirect-activation.png ECM_disassembly 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-272358
pmid sentence
Historically, MMPs were thought to function mainly as enzymes that degrade structural components of the ECM.
Publications: 1
+ MMP13down-regulates img/indirect_inhibition.png ECM 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-272381
pmid sentence
Historically, MMPs were thought to function mainly as enzymes that degrade structural components of the ECM.
Publications: 1
+ HDAC4down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MMP13 0.331
Identifier Residue Sequence Organism Cell Line
SIGNOR-254235 Homo sapiens UMR-106-01 Cell
pmid sentence
We have hypothesized that histone deacetylases (HDACs) are involved with PTH-induced MMP-13 gene expression in the osteoblastic cell line, UMR 106-01. We have shown that PTH profoundly regulates HDAC4 in UMR 106-01 cells through a PKA-dependent pathway, leading to removal of HDAC4 from the MMP-13 promoter and its enhanced transcription.
Publications: 1 Organism: Homo Sapiens
+ YBX1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MMP13 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-255615 Homo sapiens
pmid sentence
YB-1 binds to the MMP-13 promoter sequence and represses MMP-13 transactivation via the AP-1 site.
Publications: 1 Organism: Homo Sapiens
+ STAT1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MMP13 0.294
Identifier Residue Sequence Organism Cell Line
SIGNOR-255235 Homo sapiens Chondrocyte
pmid sentence
IFNgamma, through its receptor, activates STAT1, which binds with CBP/p300 coactivator, sequesters it from the cell system, and thus inhibits transcriptional induction of the MMP13 gene in chondrocytes.
Publications: 1 Organism: Homo Sapiens
+ FGF2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MMP13 0.429
Identifier Residue Sequence Organism Cell Line
SIGNOR-255079 Homo sapiens
pmid sentence
Increased expression of RUNX2 in OA cartilage may contribute to increased expression of MMP-13. FGF2, which is present in OA synovial fluid, activated RUNX2 via the MEK/ERK pathway and increased MMP-13 expression.
Publications: 1 Organism: Homo Sapiens
+ ETS1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MMP13 0.31
Identifier Residue Sequence Organism Cell Line
SIGNOR-254084 Homo sapiens SKOV-3 Cell
pmid sentence
VEGF-induced MMP-9 and MMP-13 promoter activities were down-regulated in ETS-1 siRNA-transfected cells. it is hypothesized that the activation of PI3K/AKT and p38 MAPK by VEGF results in ETS-1 gene expression, which activates MMP-9 and MMP-13, leading to the invasion and scattering of SKOV-3 cells.
Publications: 1 Organism: Homo Sapiens
+ PTHup-regulates quantity by expression img/indirect-activation.png transcriptional regulation MMP13 0.456
Identifier Residue Sequence Organism Cell Line
SIGNOR-254234 Homo sapiens
pmid sentence
Parathyroid hormone (PTH) functions as an essential regulator of calcium homeostasis and as a mediator of bone remodeling. We have already shown that PTH stimulates the expression of matrix metalloproteinase-13 (MMP-13), which is responsible for degrading components of extracellular matrix.
Publications: 1 Organism: Homo Sapiens
+ ING2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MMP13 0.393
Identifier Residue Sequence Organism Cell Line
SIGNOR-254491 Homo sapiens Colonic Adenocarcinoma Cell Line
pmid sentence
ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression.
Publications: 1 Organism: Homo Sapiens
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