| + |
CyclinD3/CDK11B | up-regulates activity 
phosphorylation
|
PAK1 |
0.395 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273129 |
Ser174 |
TPAVPPVsEDEDDDD |
|
|
| pmid |
sentence |
| 19520772 |
CDK11p58 phosphorylation of PAK1 Ser174 promotes DLC2 binding and roles on cell cycle progression|We show that PAK1 is a substrate of CDK11p58 and can be strongly activated upon phosphorylation. |
|
| Publications: |
1 |
| + |
CyclinD3/CDK11B | down-regulates quantity by destabilization 
phosphorylation
|
SPDEF |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273126 |
Ser238 |
SEESWTDsEVDSSCS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26885618 |
In this study we provide evidence that the cell cycle kinase CDK11p58, a protein involved in G2/M transition and degradation of several transcription factors, directly interacts with and phosphorylates SPDEF on serine residues|Western blot analysis demonstrated that only one of the mutant constructs, consisting of mutations of serine 238, 242 and 243, resulted in increased levels of SPDEF protein expression as compared to wild type SPDEF, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway.| |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273127 |
Ser242 |
WTDSEVDsSCSGQPI |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26885618 |
In this study we provide evidence that the cell cycle kinase CDK11p58, a protein involved in G2/M transition and degradation of several transcription factors, directly interacts with and phosphorylates SPDEF on serine residues|Western blot analysis demonstrated that only one of the mutant constructs, consisting of mutations of serine 238, 242 and 243, resulted in increased levels of SPDEF protein expression as compared to wild type SPDEF, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway.| |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273128 |
Ser243 |
TDSEVDSsCSGQPIH |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26885618 |
In this study we provide evidence that the cell cycle kinase CDK11p58, a protein involved in G2/M transition and degradation of several transcription factors, directly interacts with and phosphorylates SPDEF on serine residues|Western blot analysis demonstrated that only one of the mutant constructs, consisting of mutations of serine 238, 242 and 243, resulted in increased levels of SPDEF protein expression as compared to wild type SPDEF, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway.| |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CyclinD3/CDK11B | down-regulates quantity by destabilization
phosphorylation
|
AR |
0.582 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273130 |
Ser310 |
TEDTAEYsPFKGGYT |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 17698582 |
We found that AR was phosphorylated at Ser-308 by cyclin D3/CDK11p58 in vitro and in vivo, leading to the repressed activity of AR transcriptional activation unit 1 (TAU1). |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
CyclinD3/CDK11B | up-regulates activity
phosphorylation
|
EIF3F |
0.531 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273134 |
Ser46 |
PAAAPASsSDPAAAA |
|
|
| pmid |
sentence |
| 19245811 |
EIF3f is phosphorylated by CDK11p46 at Ser46 during apoptosis.|Phosphorylation of eIF3f plays an important role in regulating its function in translation and apoptosis. Phosphorylation of eIF3f enhances the association of eIF3f with the core eIF3 subunits during apoptosis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273132 |
Thr119 |
GAARVIGtLLGTVDK |
|
|
| pmid |
sentence |
| 19245811 |
Here, we identified a second eIF3f phosphorylation site (Thr119) by CDK11(p46) during apoptosis. We demonstrated that eIF3f is directly phosphorylated by CDK11(p46) in vivo. Phosphorylation of eIF3f plays an important role in regulating its function in translation and apoptosis. Phosphorylation of eIF3f enhances the association of eIF3f with the core eIF3 subunits during apoptosis. |
|
| Publications: |
2 |
| + |
CCND3 | form complex 
binding
|
CyclinD3/CDK11B |
0.637 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273120 |
|
|
in vitro |
|
| pmid |
sentence |
| 12082095 |
We found that AR was phosphorylated at Ser-308 by cyclin D3/CDK11p58 in vitro and in vivo, leading to the repressed activity of AR transcriptional activation unit 1 (TAU1). |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CDK11B | form complex
binding
|
CyclinD3/CDK11B |
0.637 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273119 |
|
|
in vitro |
|
| pmid |
sentence |
| 12082095 |
We found that AR was phosphorylated at Ser-308 by cyclin D3/CDK11p58 in vitro and in vivo, leading to the repressed activity of AR transcriptional activation unit 1 (TAU1). |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
CyclinD3/CDK11B