| + |
UBR5 | down-regulates quantity by destabilization 
polyubiquitination
|
SOX2 |
0.256 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277446 |
Lys115 |
YKYRPRRkTKTLMKK |
Homo sapiens |
Esophageal Squamous Cell Carcinoma Cell Line |
| pmid |
sentence |
| 30894683 |
We identified UBR5 as a major ubiquitin E3 ligase that induces SOX2 degradation through ubiquitinating SOX2 at lysine 115. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT1 | up-regulates quantity by stabilization 
phosphorylation
|
SOX2 |
0.537 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277445 |
Thr116 |
KYRPRRKtKTLMKKD |
Homo sapiens |
Esophageal Squamous Cell Carcinoma Cell Line |
| pmid |
sentence |
| 30894683 |
Phosphorylation of SOX2 at threonine 116 by AKT inhibits the interaction of UBR5 with SOX2 and thus stabilizes SOX2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | up-regulates quantity by expression
transcriptional regulation
|
SOX2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241977 |
|
|
Mus musculus |
P-19 Cell |
| pmid |
sentence |
| 24942200 |
During neural fate specification, nuclear translocation of ERK1/2 is critical for its activation of Sox2 transcription. More-over, melatonin-induced Sox2 expression, through ERK1/ 2 activation, could locate between base pairs2719 and 1708 in the mouse Sox2 gene. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SOX2/POU5F1 | up-regulates quantity by expression
transcriptional regulation
|
SOX2 |
0.84 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269253 |
|
|
|
|
| pmid |
sentence |
| 31583686 |
Both SOX2 and SOX17 are able to partner with OCT4 and, as a consequence, recognize and bind specific binding motifs.6, 7 In human and mouse ESCs, SOX2/OCT4 bind to canonical motifs (CTTTGTCATGCAAAT-like), which are composite SOX (CATTGTC-like) and OCT (ATGCAAAT-like) motifs|This way SOX17 and SOX2 regulate a common set of pluripotency and GC-related genes (PRDM14, DPPA4, TDGF1, NANOG, LIN28A, TRIM71, OTX2, PIM2) (Fig. 6). Additionally, in TCam-2 cells SOX17 binds to compressed motifs or SOX motifs (not bound by SOX2 in ECs), thereby regulating the PGC specifiers PRDM1 and TFAP2C, the GC-related genes NANOS3 and BMP7 and the cancer-related genes MYC and IGF1 (Fig. 6). In 2102EP cells, SOX2 further binds canonical elements or SOX motifs (not bound by SOX17 in TCam-2), regulating additional pluripotency genes (GDF3, LEFTY2, SALL4, SOX2 and POU5F1) (Fig. 6). |
|
| Publications: |
1 |
| + |
EGFR | up-regulates quantity by expression 
transcriptional regulation
|
SOX2 |
0.484 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-189033 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19882665 |
We show that egfr-mediated signaling promotes sox2 expression, which in turn binds to the egfr promoter and directly upregulates egfr expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Av/b1 integrin | up-regulates quantity by expression
|
SOX2 |
0.315 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253273 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18757303 |
Recombinant human LN-511 alone was suffi- cient to enable self-renewal of mouse ES cells for up to 169 days (31 passages). Cells cultured on LN-511 maintained expression of pluripotency markers, such as Oct4, Sox2, Tert, UTF1, and Nanog|ES cells interacted with LN-511 via 1-integrins, mostly a6b1 and aVb1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CTNNB1 | down-regulates activity
binding
|
SOX2 |
0.707 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241994 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 24291232 |
The interaction between Sox2 and _-catenin provides a novel mechanism underlying the functional dichotomy of BC cells, which carries potential therapeutic implications. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KDM5B | down-regulates quantity by repression
transcriptional regulation
|
SOX2 |
0.311 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273450 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 31776402 |
Phosphorylation of KDM5B at Ser1456 attenuated the occupancy of KDM5B on the promoters of pluripotency genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ID4 | up-regulates quantity by expression
transcriptional regulation
|
SOX2 |
0.413 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255180 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21531766 |
We found that ID4 enhanced SOX2 protein expression by suppressing microRNA-9* (miR-9*), which can repress SOX2 by targeting its 3'-untranslated region. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX2 | up-regulates quantity by expression
transcriptional regulation
|
NR2E1 |
0.376 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191714 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22194602 |
Sox2 positively regulates tlx expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX2 | up-regulates
|
Pluripotency |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242002 |
|
|
Homo sapiens |
Embryonic Stem Cell |
| pmid |
sentence |
| 25126380 |
Sex determining region Y-box 2 (Sox2), a member of the SoxB1 transcription factor family, is an important transcriptional regulator in pluripotent stem cells (PSCs). Together with octamer-binding transcription factor 4 and Nanog, they co-operatively control gene expression in PSCs and maintain their pluripotency. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242064 |
|
|
Homo sapiens |
Embryonic Stem Cell |
| pmid |
sentence |
| 16153702 |
Our results suggest that OCT4, SOX2, and NANOG contribute to pluripotency and self-renewal by activating their own genes and genes encoding components of key signaling pathways and by repressing genes that are key to developmental processes. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SOX2 | up-regulates quantity by expression
transcriptional regulation
|
ABCC6 |
0.284 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255182 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21531766 |
ID4-mediated SOX2 induction enhanced ABCC3 and ABCC6 expression through direct transcriptional regulation, indicating that ID4 regulates the chemoresistance of iGSCs by promoting SOX2-mediated induction of ABC transporters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
A6/b1 integrin | up-regulates quantity by expression
|
SOX2 |
0.372 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253279 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18757303 |
Recombinant human LN-511 alone was suffi- cient to enable self-renewal of mouse ES cells for up to 169 days (31 passages). Cells cultured on LN-511 maintained expression of pluripotency markers, such as Oct4, Sox2, Tert, UTF1, and Nanog|ES cells interacted with LN-511 via 1-integrins, mostly a6b1 and aVb1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SOX2 | up-regulates quantity by expression
transcriptional regulation
|
EGFR |
0.484 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-189036 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19882665 |
We show that egfr-mediated signaling promotes sox2 expression, which in turn binds to the egfr promoter and directly upregulates egfr expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHD8 | down-regulates quantity
transcriptional regulation
|
SOX2 |
0.319 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268921 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 32839322 |
Many of the most significantly up-regulated genes in Chd8+/− and Chd8−/− NPCs are involved in later stages of neuronal development, including Ascl1 [a central driver of neural reprogramming (29)], Dcx, Map2, Nefm, Neurod4, and Neurog1 (Fig. 2 E and F). Additionally, we found that Sox3 is derepressed in both Chd8+/− and Chd8−/− NPCs, and several other Sox TF members (Sox2, Sox7, and Sox11) became derepressed in the Chd8−/− cells |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CTNNB1 | up-regulates activity
binding
|
SOX2 |
0.707 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242087 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 24482235 |
The interaction of Beta-catenin with Tcf is important for Beta-catenin s's function in iPSCs induction. In addition, Beta-catenin interacts with Oct4, Sox2, and Klf4, respectively. In the reprogramming process, Beta-catenin further enhances expression of pluripotency-related genes. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
HEK-293T Cell |
| + |
SOX2 | up-regulates quantity by expression
transcriptional regulation
|
ABCC3 |
0.295 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255181 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21531766 |
ID4-mediated SOX2 induction enhanced ABCC3 and ABCC6 expression through direct transcriptional regulation, indicating that ID4 regulates the chemoresistance of iGSCs by promoting SOX2-mediated induction of ABC transporters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POU5F1 | up-regulates quantity by expression
transcriptional regulation
|
SOX2 |
0.84 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254942 |
|
|
Homo sapiens |
Embryonic Stem Cell |
| pmid |
sentence |
| 17068183 |
To enhance our understanding of the molecular basis of this differentiation event in humans, we used a functional genomics approach involving RNA interference-mediated suppression of OCT4 function in a human ESC line and analysis of the resulting transcriptional profiles to identify OCT4-dependent genes in human cells. We detected altered expression of >1,000 genes, including targets regulated directly by OCT4 either positively (NANOG, SOX2, REX1, LEFTB, LEFTA/EBAF DPPA4, THY1, and TDGF1) or negatively (CDX2, EOMES, BMP4, TBX18, Brachyury [T], DKK1, HLX1, GATA6, ID2, and DLX5), as well as targets for the OCT4-associated stem cell regulators SOX2 and NANOG. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWP2 | down-regulates quantity
ubiquitination
|
SOX2 |
0.362 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278798 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34732716 |
Among the four E3 ligases, only WWP2 knockdown was found to increase SOX2 protein levels in GSCs (Fig.\u00a04A).|We first verified that WWP2 ubiquitinates SOX2 in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX2 | form complex 
binding
|
SOX2/POU5F1 |
0.84 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-29512 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7590241 |
Sox2 can form a ternary complex with either the ubiquitous oct-1 or the embryonic-specific oct-3 protein on fgf-4 enhancer dna sequences. However, only the sox2/oct-3 complex is able to promote transcriptional activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SOX2
- 
- 