| + |
UBR5 | down-regulates quantity by destabilization 
polyubiquitination
|
SOX2 |
0.255 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277446 |
Lys115 |
YKYRPRRkTKTLMKK |
Homo sapiens |
Esophageal Squamous Cell Carcinoma Cell Line |
| pmid |
sentence |
| 30894683 |
We identified UBR5 as a major ubiquitin E3 ligase that induces SOX2 degradation through ubiquitinating SOX2 at lysine 115. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | down-regulates activity
phosphorylation
|
SOX2 |
0.453 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279071 |
Ser251 |
VKSEASSsPPVVTSS |
Homo sapiens |
|
| pmid |
sentence |
| 29556337 |
Mass spectrum analysis was employed after an in vitro kinase assay in which cells were incubated with or without ERK1-active kinase, and the results demonstrated that Sox2 was phosphorylated by ERK1 directly at S251, which was further verified by western blotting for the specific antibody targeting S251 phosphorylated Sox2 after the in vitro kinase assay.|Mechanistically, ERK1 kinase promoted autophagic degradation of Sox2 via phosphorylation of Sox2 at Ser251 and further SUMOylation of Sox2 at Lys245 in non CSCs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK2 | up-regulates activity 
phosphorylation
|
SOX2 |
0.395 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279449 |
Ser251 |
VKSEASSsPPVVTSS |
in vitro |
|
| pmid |
sentence |
| 26139602 |
Cdk2 physically interacts with Sox2 and phosphorylates Sox2 at Ser 39 and Ser 253 in vitro.|Cyclin-dependent kinase-mediated Sox2 phosphorylation enhances the ability of Sox2 to establish the pluripotent state |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279448 |
Ser37 |
AGGNQKNsPDRVKRP |
Homo sapiens |
|
| pmid |
sentence |
| 26139602 |
Cdk2 physically interacts with Sox2 and phosphorylates Sox2 at Ser 39 and Ser 253 in vitro. |
|
| Publications: |
2 |
Organism: |
In Vitro, Homo Sapiens |
| + |
AKT1 | up-regulates quantity by stabilization
phosphorylation
|
SOX2 |
0.532 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277445 |
Thr116 |
KYRPRRKtKTLMKKD |
Homo sapiens |
Esophageal Squamous Cell Carcinoma Cell Line |
| pmid |
sentence |
| 30894683 |
Phosphorylation of SOX2 at threonine 116 by AKT inhibits the interaction of UBR5 with SOX2 and thus stabilizes SOX2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279003 |
Thr118 |
RPRRKTKtLMKKDKY |
Homo sapiens |
|
| pmid |
sentence |
| 25042802 |
In contrast, phosphorylation of Sox2 by AKT1 at T118 blocks K119me by Set7 and stabilizes Sox2. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
EGFR | up-regulates quantity by stabilization
phosphorylation
|
SOX2 |
0.48 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279036 |
Tyr277 |
LRDMISMyLPGAEVP |
Homo sapiens |
|
| pmid |
sentence |
| 31823521 |
These data indicate that EGFR\u2010induced SOX2 Tyr277 phosphorylation prevents the autophagic degradation of SOX2 and enhances its stability. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX2 | up-regulates 
|
Pluripotency |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242002 |
|
|
Homo sapiens |
Embryonic Stem Cell |
| pmid |
sentence |
| 25126380 |
Sex determining region Y-box 2 (Sox2), a member of the SoxB1 transcription factor family, is an important transcriptional regulator in pluripotent stem cells (PSCs). Together with octamer-binding transcription factor 4 and Nanog, they co-operatively control gene expression in PSCs and maintain their pluripotency. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242064 |
|
|
Homo sapiens |
Embryonic Stem Cell |
| pmid |
sentence |
| 16153702 |
Our results suggest that OCT4, SOX2, and NANOG contribute to pluripotency and self-renewal by activating their own genes and genes encoding components of key signaling pathways and by repressing genes that are key to developmental processes. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
VRK1 | up-regulates activity
phosphorylation
|
SOX2 |
0.468 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279578 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27334688 |
VRK1, but not kinase-dead VRK1 (K179E), phosphorylated Sox2 (XREF_FIG). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Av/b1 integrin | up-regulates quantity by expression
|
SOX2 |
0.314 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253273 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18757303 |
Recombinant human LN-511 alone was suffi- cient to enable self-renewal of mouse ES cells for up to 169 days (31 passages). Cells cultured on LN-511 maintained expression of pluripotency markers, such as Oct4, Sox2, Tert, UTF1, and Nanog|ES cells interacted with LN-511 via 1-integrins, mostly a6b1 and aVb1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
POU5F1 | up-regulates quantity by expression
transcriptional regulation
|
SOX2 |
0.841 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254942 |
|
|
Homo sapiens |
Embryonic Stem Cell |
| pmid |
sentence |
| 17068183 |
To enhance our understanding of the molecular basis of this differentiation event in humans, we used a functional genomics approach involving RNA interference-mediated suppression of OCT4 function in a human ESC line and analysis of the resulting transcriptional profiles to identify OCT4-dependent genes in human cells. We detected altered expression of >1,000 genes, including targets regulated directly by OCT4 either positively (NANOG, SOX2, REX1, LEFTB, LEFTA/EBAF DPPA4, THY1, and TDGF1) or negatively (CDX2, EOMES, BMP4, TBX18, Brachyury [T], DKK1, HLX1, GATA6, ID2, and DLX5), as well as targets for the OCT4-associated stem cell regulators SOX2 and NANOG. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX2 | up-regulates quantity by expression
transcriptional regulation
|
EGFR |
0.48 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-189036 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19882665 |
We show that egfr-mediated signaling promotes sox2 expression, which in turn binds to the egfr promoter and directly upregulates egfr expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX2 | form complex 
binding
|
SOX2/POU5F1 |
0.841 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-29512 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7590241 |
Sox2 can form a ternary complex with either the ubiquitous oct-1 or the embryonic-specific oct-3 protein on fgf-4 enhancer dna sequences. However, only the sox2/oct-3 complex is able to promote transcriptional activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
A6/b1 integrin | up-regulates quantity by expression
|
SOX2 |
0.37 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253279 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18757303 |
Recombinant human LN-511 alone was suffi- cient to enable self-renewal of mouse ES cells for up to 169 days (31 passages). Cells cultured on LN-511 maintained expression of pluripotency markers, such as Oct4, Sox2, Tert, UTF1, and Nanog|ES cells interacted with LN-511 via 1-integrins, mostly a6b1 and aVb1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SOX2/POU5F1 | up-regulates quantity by expression
transcriptional regulation
|
SOX2 |
0.841 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269253 |
|
|
|
|
| pmid |
sentence |
| 31583686 |
Both SOX2 and SOX17 are able to partner with OCT4 and, as a consequence, recognize and bind specific binding motifs.6, 7 In human and mouse ESCs, SOX2/OCT4 bind to canonical motifs (CTTTGTCATGCAAAT-like), which are composite SOX (CATTGTC-like) and OCT (ATGCAAAT-like) motifs|This way SOX17 and SOX2 regulate a common set of pluripotency and GC-related genes (PRDM14, DPPA4, TDGF1, NANOG, LIN28A, TRIM71, OTX2, PIM2) (Fig. 6). Additionally, in TCam-2 cells SOX17 binds to compressed motifs or SOX motifs (not bound by SOX2 in ECs), thereby regulating the PGC specifiers PRDM1 and TFAP2C, the GC-related genes NANOS3 and BMP7 and the cancer-related genes MYC and IGF1 (Fig. 6). In 2102EP cells, SOX2 further binds canonical elements or SOX motifs (not bound by SOX17 in TCam-2), regulating additional pluripotency genes (GDF3, LEFTY2, SALL4, SOX2 and POU5F1) (Fig. 6). |
|
| Publications: |
1 |
| + |
WWP2 | down-regulates quantity
ubiquitination
|
SOX2 |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278798 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34732716 |
Among the four E3 ligases, only WWP2 knockdown was found to increase SOX2 protein levels in GSCs (Fig.\u00a04A).|We first verified that WWP2 ubiquitinates SOX2 in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | up-regulates quantity by expression
transcriptional regulation
|
SOX2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241977 |
|
|
Mus musculus |
P-19 Cell |
| pmid |
sentence |
| 24942200 |
During neural fate specification, nuclear translocation of ERK1/2 is critical for its activation of Sox2 transcription. More-over, melatonin-induced Sox2 expression, through ERK1/ 2 activation, could locate between base pairs2719 and 1708 in the mouse Sox2 gene. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
KDM5B | down-regulates quantity by repression
transcriptional regulation
|
SOX2 |
0.31 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273450 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 31776402 |
Phosphorylation of KDM5B at Ser1456 attenuated the occupancy of KDM5B on the promoters of pluripotency genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ID4 | up-regulates quantity by expression
transcriptional regulation
|
SOX2 |
0.411 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255180 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21531766 |
We found that ID4 enhanced SOX2 protein expression by suppressing microRNA-9* (miR-9*), which can repress SOX2 by targeting its 3'-untranslated region. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX2 | up-regulates quantity by expression
transcriptional regulation
|
NR2E1 |
0.374 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191714 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22194602 |
Sox2 positively regulates tlx expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | up-regulates activity
binding
|
SOX2 |
0.71 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242087 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 24482235 |
The interaction of Beta-catenin with Tcf is important for Beta-catenin s's function in iPSCs induction. In addition, Beta-catenin interacts with Oct4, Sox2, and Klf4, respectively. In the reprogramming process, Beta-catenin further enhances expression of pluripotency-related genes. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
HEK-293T Cell |
| + |
SOX2 | up-regulates quantity by expression
transcriptional regulation
|
ABCC6 |
0.283 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255182 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21531766 |
ID4-mediated SOX2 induction enhanced ABCC3 and ABCC6 expression through direct transcriptional regulation, indicating that ID4 regulates the chemoresistance of iGSCs by promoting SOX2-mediated induction of ABC transporters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX2 | up-regulates quantity by expression
transcriptional regulation
|
ABCC3 |
0.294 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255181 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21531766 |
ID4-mediated SOX2 induction enhanced ABCC3 and ABCC6 expression through direct transcriptional regulation, indicating that ID4 regulates the chemoresistance of iGSCs by promoting SOX2-mediated induction of ABC transporters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | down-regulates activity
binding
|
SOX2 |
0.71 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241994 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 24291232 |
The interaction between Sox2 and _-catenin provides a novel mechanism underlying the functional dichotomy of BC cells, which carries potential therapeutic implications. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHD8 | down-regulates quantity
transcriptional regulation
|
SOX2 |
0.318 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268921 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 32839322 |
Many of the most significantly up-regulated genes in Chd8+/− and Chd8−/− NPCs are involved in later stages of neuronal development, including Ascl1 [a central driver of neural reprogramming (29)], Dcx, Map2, Nefm, Neurod4, and Neurog1 (Fig. 2 E and F). Additionally, we found that Sox3 is derepressed in both Chd8+/− and Chd8−/− NPCs, and several other Sox TF members (Sox2, Sox7, and Sox11) became derepressed in the Chd8−/− cells |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PAK6 | up-regulates quantity
phosphorylation
|
SOX2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280060 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32721391 |
PAK5 promotes the cell stemness ability by phosphorylating SOX2 in lung squamous cell carcinomas.|The absence of PAK5 abolishes self-renewal ability of LUSC cells by decreasing the expression and phosphorylation of SOX2 in vitro and in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGFR | up-regulates quantity by expression
transcriptional regulation
|
SOX2 |
0.48 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-189033 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19882665 |
We show that egfr-mediated signaling promotes sox2 expression, which in turn binds to the egfr promoter and directly upregulates egfr expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
SOX2
- 
- 