Summary

Name CCN4
Full Name CCN family member 4
Synonyms WISP-1, CCN family member 4, Wnt-1-induced secreted protein | CCN4
Primary ID O95388
Links - -
Type protein
Relations 2
Pathways Satellite: IGF1R
Function Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation AKT 0.2
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates quantity img/direct-activation.png transcriptional regulation CCN4 0.2
Publications: 1 Organism: Rattus Norvegicus