4.0
Summary
| Name |  CCN4View Modifications |
| Full Name | CCN family member 4 |
| Synonyms | WISP-1, CCN family member 4, Wnt-1-induced secreted protein | CCN4 |
| Primary ID | O95388 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Pathways | Satellite: IGF1R |
| Function | Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. |
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phosphorylation