3.0
Summary
| Name |  BMP10
|
| Full Name | Bone morphogenetic protein 10 |
| Synonyms | BMP-10 |
| Primary ID | O95393 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. |
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