Relation Results

Summary

Name ENG
Full Name Endoglin
Synonyms EGLN_HUMAN | END
Primary ID P17813
Links - -
Type protein
Relations 7
Function Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for norm ...
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Type: Score: Layout: SPV 
0.3920.20.6990.7390.3690.2SRCENGSP1TGFB1GDF2BMP10ERG

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ SRCdown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation ENG 0.392
Identifier Residue Sequence Organism Cell Line
SIGNOR-276655 Tyr612 LLTAALWyIYSHTRS Homo sapiens HMEC-1 Cell
pmid sentence
We identified epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) as Src-activators that induce endoglin turnover following (612)YIY(614) phosphorylation. 
Identifier Residue Sequence Organism Cell Line
SIGNOR-276654 Tyr614 TAALWYIySHTRSPS Homo sapiens HMEC-1 Cell
pmid sentence
We identified epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) as Src-activators that induce endoglin turnover following (612)YIY(614) phosphorylation. 
Publications: 2 Organism: Homo Sapiens
+ SP1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ENG 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-255201 Homo sapiens Hepatic Stellate Cell
pmid sentence
In hepatic stellate cells, TGF-β1 upregulates endoglin expression most likely via the ALK5 pathway and requires the SP1 transcription factor.
Publications: 1 Organism: Homo Sapiens
+ TGFB1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ENG 0.699
Identifier Residue Sequence Organism Cell Line
SIGNOR-255202 Homo sapiens Hepatic Stellate Cell
pmid sentence
In hepatic stellate cells, TGF-β1 upregulates endoglin expression most likely via the ALK5 pathway and requires the SP1 transcription factor.
Publications: 1 Organism: Homo Sapiens
+ ENGup-regulates activity img/direct-activation.png binding GDF2 0.739
Identifier Residue Sequence Organism Cell Line
SIGNOR-276656 Homo sapiens A-204 Cell
pmid sentence
Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. We found that mouse and human endoglin ECD-Fc bound directly, specifically, and with high affinity to bone morphogenetic proteins 9 and 10 (BMP9 and BMP10) in surface plasmon resonance (Biacore) and cell-based assays.
Publications: 1 Organism: Homo Sapiens
+ ENGup-regulates activity img/direct-activation.png binding BMP10 0.369
Identifier Residue Sequence Organism Cell Line
SIGNOR-276657 Homo sapiens A-204 Cell
pmid sentence
Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. We found that mouse and human endoglin ECD-Fc bound directly, specifically, and with high affinity to bone morphogenetic proteins 9 and 10 (BMP9 and BMP10) in surface plasmon resonance (Biacore) and cell-based assays.
Publications: 1 Organism: Homo Sapiens
+ ERGup-regulates quantity by expression img/indirect-activation.png transcriptional regulation ENG 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253916 Homo sapiens
pmid sentence
It has been shown that ERG is a positive regulator of several EC-restricted genes including VE-cadherin, endoglin, and von Willebrand factor, and a negative regulator of other genes such as interleukin (IL)-8 and intercellular adhesion molecule (ICAM)-1.
Publications: 1 Organism: Homo Sapiens
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