| + |
KLF3 | down-regulates quantity by repression 
transcriptional regulation
|
KLF8 |
0.258 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266049 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18687676 |
Here we report that Klf8 is repressed by Klf3 in vivo and is up-regulated by Klf1. Transcript analysis indicates that Klf8 has two promoters, both containing multiple CACCC elements. Transactivation assays and chromatin immunoprecipitation experiments indicate that Klf3 represses Klf8 directly and that Klf1 activates Klf8 directly. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Liver |
| + |
KLF1 | up-regulates quantity by expression 
transcriptional regulation
|
KLF8 |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266050 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18687676 |
Here we report that Klf8 is repressed by Klf3 in vivo and is up-regulated by Klf1. Transcript analysis indicates that Klf8 has two promoters, both containing multiple CACCC elements. Transactivation assays and chromatin immunoprecipitation experiments indicate that Klf3 represses Klf8 directly and that Klf1 activates Klf8 directly. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Liver |
| + |
KLF8 | up-regulates activity
binding
|
CTBP2 |
0.547 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236962 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 10756197 |
Here we report the characterisation of KLF8/ZNF741/BKLF3 (KLF8). We demonstrate that this protein is able to bind CACCC-boxes in DNA and can repress gene expression by associating with CtBP co-repressors. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
KLF8 | down-regulates quantity by repression
transcriptional regulation
|
HBB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266052 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 10756197 |
These results establish KLF8 as a CACCC-box binding protein that associates with CtBP and represses transcription. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
KLF8
- 
- 