3.0
Summary
| Name |  KLF1View Modifications |
| Full Name | Krueppel-like factor 1 |
| Synonyms | Erythroid krueppel-like transcription factor, EKLF | EKLF |
| Primary ID | Q13351 |
| Links |  -  -  |
| Type | protein |
| Relations | 12 |
| Pathways | HaematopoiesisTranscriptionalControl |
| Function | Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CREBBP | up-regulates activity 
acetylation
|
KLF1 | 0.504 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CSNK2A1 | up-regulates activity
phosphorylation
|
KLF1 | 0.349 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | CSNK2A2 | up-regulates activity
phosphorylation
|
KLF1 | 0.348 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | CBP/p300 | up-regulates activity
acetylation
|
KLF1 | 0.472 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KLF1 | up-regulates 
|
Erythrocyte_differentiation | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | HaematopoiesisTranscriptionalControl | |||
| + | FLI1 | down-regulates activity 
binding
|
KLF1 | 0.378 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | HaematopoiesisTranscriptionalControl | |||
| + | KLF1 | up-regulates quantity by expression
transcriptional regulation
|
KLF8 | 0.253 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Tissue: | Liver | |||
| + | KLF1 | down-regulates activity
binding
|
FLI1 | 0.378 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | HaematopoiesisTranscriptionalControl | |||
| + | GATA1 | up-regulates quantity by expression
transcriptional regulation
|
KLF1 | 0.517 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | HaematopoiesisTranscriptionalControl | |||
| + | GATA2 | up-regulates quantity by expression
transcriptional regulation
|
KLF1 | 0.442 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | HaematopoiesisTranscriptionalControl | |||
| + | KLF1 | up-regulates quantity by expression
transcriptional regulation
|
HBB | 0.415 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KLF1 | up-regulates quantity by expression
transcriptional regulation
|
CDKN2C | 0.269 |
| Publications: | 1 | Organism: | Drosophila Melanogaster | |