Summary

Name ZBED1
Full Name E3 SUMO-protein ligase ZBED1
Synonyms Putative Ac-like transposable element, dREF homolog | ALTE, DREF, KIAA0785, TRAMP
Primary ID O96006
Links - -
Type protein
Relations 5
Function Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA (PubMed:27068747). This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation RPS6 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation RPS12 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation RPS10 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ZBED1 0.422
Publications: 1 Organism: Drosophila Melanogaster
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GATA4 0.2
Publications: 1 Organism: Drosophila Melanogaster