| + |
RPS6KB1 | up-regulates activity 
phosphorylation
|
RPS6 |
0.936 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135172 |
Ser235 |
IAKRRRLsSLRASTS |
Mus musculus |
|
| pmid |
sentence |
| 15809305 |
A knockin mouse carrying mutations at all phosphorylation sites in the primary s6k substrate, ribosomal protein s6 (rps6), has provided insight into the physiological role of this protein phosphorylation event. Of the many known substrates of s6k1, it is rps6 that has been shown to be directly involved, via its phosphorylation, in controlling cell size. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135176 |
Ser236 |
AKRRRLSsLRASTSK |
Mus musculus |
|
| pmid |
sentence |
| 15809305 |
A knockin mouse carrying mutations at all phosphorylation sites in the primary s6k substrate, ribosomal protein s6 (rps6), has provided insight into the physiological role of this protein phosphorylation event. Of the many known substrates of s6k1, it is rps6 that has been shown to be directly involved, via its phosphorylation, in controlling cell size. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| Pathways: | MTOR Signaling |
| + |
RPS6K | up-regulates
phosphorylation
|
RPS6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252813 |
Ser235 |
IAKRRRLsSLRASTS |
Homo sapiens |
|
| pmid |
sentence |
| 17360704 |
We demonstrate that while ribosomal s6 kinase 1 (s6k1) phosphorylates rps6 at all sites, rsk exclusively phosphorylates rps6 at ser(235/236) in vitro and in vivo using an mtor-independent mechanism. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252812 |
Ser236 |
AKRRRLSsLRASTSK |
Homo sapiens |
|
| pmid |
sentence |
| 17360704 |
We demonstrate that while ribosomal s6 kinase 1 (s6k1) phosphorylates rps6 at all sites, rsk exclusively phosphorylates rps6 at ser(235/236) in vitro and in vivo using an mtor-independent mechanism. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252765 |
Ser240 |
RLSSLRAsTSKSESS |
Homo sapiens |
|
| pmid |
sentence |
| 21233202 |
In response to mitogenic stimuli, rps6 undergoes ordered c-terminal phosphorylation by p70 s6 kinases and p90 ribosomal s6 kinases on four conserved ser residues (ser-235, ser-236, ser-240, and ser-244) whose modification potentiates rps6 cap binding activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252764 |
Ser244 |
LRASTSKsESSQK |
Homo sapiens |
|
| pmid |
sentence |
| 21233202 |
In response to mitogenic stimuli, rps6 undergoes ordered c-terminal phosphorylation by p70 s6 kinases and p90 ribosomal s6 kinases on four conserved ser residues (ser-235, ser-236, ser-240, and ser-244) whose modification potentiates rps6 cap binding activity |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
PAK2 |
phosphorylation
|
RPS6 |
0.313 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250231 |
Ser235 |
IAKRRRLsSLRASTS |
in vitro |
|
| pmid |
sentence |
| 1985906 |
The synthetic peptide AKRRRLSSLRASTSKSESSQK (S6-21) which corresponds to the carboxyl-terminal 21 amino acids of human ribosomal protein S6 was synthesized and tested as a substrate for S6/H4 kinase purified from human placenta. The principal phosphorylation sites were serines in the acidic carboxyl-terminal domain of the peptide. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250232 |
Ser236 |
AKRRRLSsLRASTSK |
in vitro |
|
| pmid |
sentence |
| 1985906 |
The synthetic peptide AKRRRLSSLRASTSKSESSQK (S6-21) which corresponds to the carboxyl-terminal 21 amino acids of human ribosomal protein S6 was synthesized and tested as a substrate for S6/H4 kinase purified from human placenta. The principal phosphorylation sites were serines in the acidic carboxyl-terminal domain of the peptide. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250233 |
Ser240 |
RLSSLRAsTSKSESS |
in vitro |
|
| pmid |
sentence |
| 1985906 |
The synthetic peptide AKRRRLSSLRASTSKSESSQK (S6-21) which corresponds to the carboxyl-terminal 21 amino acids of human ribosomal protein S6 was synthesized and tested as a substrate for S6/H4 kinase purified from human placenta. The principal phosphorylation sites were serines in the acidic carboxyl-terminal domain of the peptide. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250234 |
Ser242 |
SSLRASTsKSESSQK |
in vitro |
|
| pmid |
sentence |
| 1985906 |
The synthetic peptide AKRRRLSSLRASTSKSESSQK (S6-21) which corresponds to the carboxyl-terminal 21 amino acids of human ribosomal protein S6 was synthesized and tested as a substrate for S6/H4 kinase purified from human placenta. The principal phosphorylation sites were serines in the acidic carboxyl-terminal domain of the peptide. |
|
| Publications: |
4 |
Organism: |
In Vitro |
| + |
RPS6KA1 | up-regulates
phosphorylation
|
RPS6 |
0.608 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153618 |
Ser235 |
IAKRRRLsSLRASTS |
Homo sapiens |
|
| pmid |
sentence |
| 17360704 |
We demonstrate that while ribosomal s6 kinase 1 (s6k1) phosphorylates rps6 at all sites, rsk exclusively phosphorylates rps6 at ser(235/236) in vitro and in vivo using an mtor-independent mechanism. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153622 |
Ser236 |
AKRRRLSsLRASTSK |
Homo sapiens |
|
| pmid |
sentence |
| 17360704 |
We demonstrate that while ribosomal s6 kinase 1 (s6k1) phosphorylates rps6 at all sites, rsk exclusively phosphorylates rps6 at ser(235/236) in vitro and in vivo using an mtor-independent mechanism. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-171243 |
Ser240 |
RLSSLRAsTSKSESS |
Homo sapiens |
|
| pmid |
sentence |
| 21233202 |
In response to mitogenic stimuli, rps6 undergoes ordered c-terminal phosphorylation by p70 s6 kinases and p90 ribosomal s6 kinases on four conserved ser residues (ser-235, ser-236, ser-240, and ser-244) whose modification potentiates rps6 cap binding activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-171247 |
Ser244 |
LRASTSKsESSQK |
Homo sapiens |
|
| pmid |
sentence |
| 21233202 |
In response to mitogenic stimuli, rps6 undergoes ordered c-terminal phosphorylation by p70 s6 kinases and p90 ribosomal s6 kinases on four conserved ser residues (ser-235, ser-236, ser-240, and ser-244) whose modification potentiates rps6 cap binding activity |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | MTOR Signaling |
| + |
RPS6 | form complex 
binding
|
40S cytosolic small ribosomal subunit |
0.882 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262418 |
|
|
in vitro |
|
| pmid |
sentence |
| 25901680 |
Here we report the near-atomic structure of the human ribosome derived from high-resolution single-particle cryo-electron microscopy and atomic model building. The structure has an average resolution of 3.6 Å, reaching 2.9 Å resolution in the most stable regions. |The human ribosome (80S) has a molecular weight of 4.3 MDa: the large subunit (60S) consists of 28S, 5S and 5.8S rRNAs and 47 proteins, while the small subunit (40S) possesses a single 18S rRNA chain and 33 pro- teins. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
miR-199a | up-regulates activity
|
RPS6 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255936 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21986534 |
This overexpression of miR-155 may suppress the expression of C/EBPβ and CREB by directly targeting their 3' untranslated regions (3' UTRs) |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ZBED1 | up-regulates quantity by expression
transcriptional regulation
|
RPS6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266082 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17220279 |
HDRE-like sequences act as positive regulatory elements for RP gene promoter activities in vivo. | Cotransfection of a plasmid expressing hDREF increased luciferase expression directed by each RP gene promoter more than 30% compared with the values obtained without the hDREF-expressing plasmid. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6 | up-regulates 
|
Ribosome biogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264619 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23318442 |
Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264617 |
|
|
in vitro |
|
| pmid |
sentence |
| 19812304 |
The stimulation of S6K1 activity by mTORC1 leads to increases in mRNA biogenesis, cap-dependent translation and elongation, and the translation of ribosomal proteins through regulation of the activity of many proteins, such as S6K1 aly/REF-like target (SKAR), programmed cell death 4 (PDCD4), eukaryotic elongation factor 2 kinase (eEF2K) and ribosomal protein S6 |
|
| Publications: |
2 |
Organism: |
Mus Musculus, In Vitro |
3.0
RPS6
- 
- 