| + |
SRF | up-regulates quantity by expression 
transcriptional regulation
|
PLAU |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255227 |
|
|
Homo sapiens |
Lung Fibroblast Cell Line |
| pmid |
sentence |
| 15514113 |
We previously demonstrated that serum response factor (SRF), a critical smooth muscle transcription factor, is highly expressed in LAM cells. Here we show that a high SRF level alters the plasminogen (Plg) system. Specifically, overexpression of SRF in human lung fibroblasts upregulated urokinase-type plasminogen activator (uPA) and its substrate Plg, whereas it downregulated plasminogen activator inhibitor (PAI)-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLAU | up-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252264 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19055748 |
Our data show that functional blockade of SNAI1 (SNAI1-dominant negative (DN)) leads to a partial re-expression of E-cadherin, and induces differential expression of EMT-related genes. This is confirmed by RT-PCR of PA system genes, where PAI-1 and uPA are decreased. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EIF3E | up-regulates quantity
translation regulation
|
PLAU |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259155 |
|
|
Homo sapiens |
MDA-MB-231 Cell, U2-OS Cell |
| pmid |
sentence |
| 20453879 |
Validated mRNA targets regulated positively at the translational level by eIF3e included urokinase-type plasminogen activator and apoptotic regulator BCL-XL, whereas synthesis of proteins including the mitotic checkpoint component MAD2L1 was negatively regulated. Taken together, our study data suggest that eIF3e has a positive role in breast cancer progression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SNAI1 | up-regulates quantity by expression
transcriptional regulation
|
PLAU |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252263 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19055748 |
We demonstrated by both cDNA microarrays and real-time quantitative RT-PCR that the functional blockade of SNAI1 induces a significant decrease of PAI-1 and uPA transcripts. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLAU | up-regulates 
binding
|
PLAUR |
0.888 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144306 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16456079 |
The urokinase plasminogen activator binds to its cellular receptor with high affinity and initiates signaling cascades that are implicated in pathological processes including tumor growth, metastasis, and inflammation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PLAU
- 
- 