| + |
C5 convertase complex (C3bBbC3b) | up-regulates activity 
cleavage
|
C5 |
0.538 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263481 |
Arg677 |
KEILRPRrTLQKKIE |
Homo sapiens |
|
| pmid |
sentence |
| 26489954 |
In addition to the surface‐bound C3 convertase, a fluid‐phase convertase can be formed by association of water‐reacted C3, termed C3(H20), to FB thus constantly maintaining a low level of complement activation in solution (tick‐over). Both of the surface‐bound C3 convertases can bind a C3b molecule whereby the C5 convertases are formed. These cleave C5 into C5a and C5b, thus initiating the terminal pathway and leading to formation of the membrane attack complex (MAC). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263482 |
Arg751 |
HKDMQLGrLHMKTLL |
Homo sapiens |
|
| pmid |
sentence |
| 26489954 |
In addition to the surface‐bound C3 convertase, a fluid‐phase convertase can be formed by association of water‐reacted C3, termed C3(H20), to FB thus constantly maintaining a low level of complement activation in solution (tick‐over). Both of the surface‐bound C3 convertases can bind a C3b molecule whereby the C5 convertases are formed. These cleave C5 into C5a and C5b, thus initiating the terminal pathway and leading to formation of the membrane attack complex (MAC). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood |
| + |
C5 convertase complex | up-regulates activity
cleavage
|
C5 |
0.538 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263452 |
Arg677 |
KEILRPRrTLQKKIE |
|
|
| pmid |
sentence |
| 31331124 |
Association of C3b with C3 convertases (C3bBb or C4b2a) results in formation of C5 convertases, C3bBbC3b and C4b2aC3b, which initiate the lytic pathway by cleavage of C5 to C5a and C5b |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263453 |
Arg751 |
HKDMQLGrLHMKTLL |
|
|
| pmid |
sentence |
| 31331124 |
Association of C3b with C3 convertases (C3bBb or C4b2a) results in formation of C5 convertases, C3bBbC3b and C4b2aC3b, which initiate the lytic pathway by cleavage of C5 to C5a and C5b |
|
| Publications: |
2 |
| Pathways: | Complement Signaling |
| + |
C5 | up-regulates activity
binding
|
C5AR1 |
0.748 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263457 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1847994 |
The chemotactic receptor for human C5a anaphylatoxin|The human C5a receptor was cloned from U937 and HL-60 cells and identified by high affinity binding when expressed in COS-7 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Complement Signaling |
| + |
C5 | form complex 
binding
|
Membrane attack complex |
0.606 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263440 |
|
|
in vitro |
|
| pmid |
sentence |
| 30552328 |
The human MAC pore was formed on liposomes from individual complement proteins. |The maps were further subdivided into three components: an asymmetric region (C5b, C6, C7, and C8), a hinge region (C7, C8, and two C9 molecules), and a C9 oligomer |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Complement Signaling |
| + |
C5 | up-regulates
binding
|
C5AR2 |
0.649 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-113558 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11773063 |
Here we report that the orphan receptor c5l2/gpr77, which shares 35% amino acid identity with cd88, binds c5a with high affinity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
C5
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