Relation Results

Summary

Name C5AR1
Full Name C5a anaphylatoxin chemotactic receptor 1
Synonyms C5a anaphylatoxin chemotactic receptor, C5a-R, C5aR | C5AR, C5R1
Primary ID P21730
Links - -
Type protein
Relations 12
Pathways Complement Signaling
Function Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:106368 ...
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Type: Score: Layout: SPV 
0.20.20.70.80.80.70.330.460.7470.378PRKCDC5AR1PRKCBInflammationsuperoxideAvacopanChemotaxisSELLCR1C5ITGAM

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Relations
Regulator
Mechanism
target
score ℹ
+ PRKCDdown-regulates img/direct_inhibition.png phosphorylation C5AR1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-151015 Ser334 SVVRESKsFTRSTVD Homo sapiens
pmid sentence
Whole cell phosphorylation assays with specific inhibitors as well as in vitro phosphorylation assays with recombinant enzymes and peptide substrates revealed that phosphorylation of ser-334 is regulated by protein kinase c-beta this study is among the first to analyze in a detailed manner, using a non-mutational approach, modifications of a defined phosphorylation site in a g protein-coupled receptor and to correlate these findings with functional parameters of receptor deactivation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-96067 Ser334 SVVRESKsFTRSTVD Homo sapiens
pmid sentence
Whole cell phosphorylation assays with specific inhibitors as well as in vitro phosphorylation assays with recombinant enzymes and peptide substrates revealed that phosphorylation of ser-334 is regulated by protein kinase c-beta this study is among the first to analyze in a detailed manner, using a non-mutational approach, modifications of a defined phosphorylation site in a g protein-coupled receptor and to correlate these findings with functional parameters of receptor deactivation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-73967 Ser334 SVVRESKsFTRSTVD Homo sapiens
pmid sentence
Whole cell phosphorylation assays with specific inhibitors as well as in vitro phosphorylation assays with recombinant enzymes and peptide substrates revealed that phosphorylation of ser-334 is regulated by protein kinase c-beta this study is among the first to analyze in a detailed manner, using a non-mutational approach, modifications of a defined phosphorylation site in a g protein-coupled receptor and to correlate these findings with functional parameters of receptor deactivation.
Publications: 3 Organism: Homo Sapiens
+ PRKCBdown-regulates img/direct_inhibition.png phosphorylation C5AR1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-151011 Ser334 SVVRESKsFTRSTVD Homo sapiens
pmid sentence
Dynamics of protein kinase c-mediated phosphorylation of the complement c5a receptor on serine 334. Analysis of c5ar ser/ala mutants that possess a single intact serine residue either at position 334 or at neighboring positions 327, 332, or 338 revealed functional redundancy of c-terminal phosphorylation sites since all 4 serine residues could individually support c5ar internalization and desensitization
Publications: 1 Organism: Homo Sapiens
+ C5AR1up-regulates img/indirect-activation.png Inflammation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-263462
pmid sentence
The C5a receptor mediates the pro-inflammatory and chemotactic actions of the complement anaphylatoxin C5a. In addition to stimulating chemotaxis, granule enzyme release and superoxide anion production, this receptor stimulates upregulation of expression and activity of the adhesion molecule MAC-1, and of CR1, and a decrease in cell-surface glycoprotein 100MEL-14 on neutrophils.
Publications: 1
Pathways:Complement Signaling
+ C5AR1up-regulates quantity by expression img/indirect-activation.png superoxide 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-263469
pmid sentence
The C5a receptor mediates the pro-inflammatory and chemotactic actions of the complement anaphylatoxin C5a. In addition to stimulating chemotaxis, granule enzyme release and superoxide anion production, this receptor stimulates upregulation of expression and activity of the adhesion molecule MAC-1, and of CR1, and a decrease in cell-surface glycoprotein 100MEL-14 on neutrophils.
Publications: 1
Pathways:Complement Signaling
+ Avacopandown-regulates activity img/direct_inhibition.png binding C5AR1 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-263473 Homo sapiens
pmid sentence
CCX168 (avocapan), a C5aR antagonist, has proven its safety and efficiency in phase I and phase II trials conducted in AAV patients.
Publications: 1 Organism: Homo Sapiens
+ C5AR1up-regulates img/indirect-activation.png Chemotaxis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-263460 Homo sapiens
pmid sentence
We report here that the anaphylatoxins C3a and C5a are chemotactic factors for the human mast cell line HMC-1, human cord blood-derived mast cells (CBMC) and cutaneous mast cells in vitro.
Publications: 1 Organism: Homo Sapiens
Pathways:Complement Signaling
+ C5AR1down-regulates quantity by repression img/indirect_inhibition.png SELL 0.33
Identifier Residue Sequence Organism Cell Line
SIGNOR-263468
pmid sentence
The C5a receptor mediates the pro-inflammatory and chemotactic actions of the complement anaphylatoxin C5a. In addition to stimulating chemotaxis, granule enzyme release and superoxide anion production, this receptor stimulates upregulation of expression and activity of the adhesion molecule MAC-1, and of CR1, and a decrease in cell-surface glycoprotein 100MEL-14 on neutrophils.
Publications: 1
+ C5AR1up-regulates quantity by expression img/indirect-activation.png CR1 0.46
Identifier Residue Sequence Organism Cell Line
SIGNOR-263466
pmid sentence
The C5a receptor mediates the pro-inflammatory and chemotactic actions of the complement anaphylatoxin C5a. In addition to stimulating chemotaxis, granule enzyme release and superoxide anion production, this receptor stimulates upregulation of expression and activity of the adhesion molecule MAC-1, and of CR1, and a decrease in cell-surface glycoprotein 100MEL-14 on neutrophils.
Publications: 1
+ C5up-regulates activity img/direct-activation.png binding C5AR1 0.747
Identifier Residue Sequence Organism Cell Line
SIGNOR-263457 Homo sapiens
pmid sentence
The chemotactic receptor for human C5a anaphylatoxin|The human C5a receptor was cloned from U937 and HL-60 cells and identified by high affinity binding when expressed in COS-7 cells.
Publications: 1 Organism: Homo Sapiens
Pathways:Complement Signaling
+ C5AR1up-regulates quantity by expression img/indirect-activation.png ITGAM 0.378
Identifier Residue Sequence Organism Cell Line
SIGNOR-263464
pmid sentence
The C5a receptor mediates the pro-inflammatory and chemotactic actions of the complement anaphylatoxin C5a. In addition to stimulating chemotaxis, granule enzyme release and superoxide anion production, this receptor stimulates upregulation of expression and activity of the adhesion molecule MAC-1, and of CR1, and a decrease in cell-surface glycoprotein 100MEL-14 on neutrophils.
Publications: 1
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