| + |
C5 convertase complex (C3bBbC3b) | up-regulates activity 
cleavage
|
C5 |
0.538 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263481 |
Arg677 |
KEILRPRrTLQKKIE |
Homo sapiens |
|
| pmid |
sentence |
| 26489954 |
In addition to the surface‐bound C3 convertase, a fluid‐phase convertase can be formed by association of water‐reacted C3, termed C3(H20), to FB thus constantly maintaining a low level of complement activation in solution (tick‐over). Both of the surface‐bound C3 convertases can bind a C3b molecule whereby the C5 convertases are formed. These cleave C5 into C5a and C5b, thus initiating the terminal pathway and leading to formation of the membrane attack complex (MAC). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263482 |
Arg751 |
HKDMQLGrLHMKTLL |
Homo sapiens |
|
| pmid |
sentence |
| 26489954 |
In addition to the surface‐bound C3 convertase, a fluid‐phase convertase can be formed by association of water‐reacted C3, termed C3(H20), to FB thus constantly maintaining a low level of complement activation in solution (tick‐over). Both of the surface‐bound C3 convertases can bind a C3b molecule whereby the C5 convertases are formed. These cleave C5 into C5a and C5b, thus initiating the terminal pathway and leading to formation of the membrane attack complex (MAC). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood |
| + |
C3 convertase complex (C3bBb) | form complex 
binding
|
C5 convertase complex (C3bBbC3b) |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263479 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26489954 |
In addition to the surface‐bound C3 convertase, a fluid‐phase convertase can be formed by association of water‐reacted C3, termed C3(H20), to FB thus constantly maintaining a low level of complement activation in solution (tick‐over). Both of the surface‐bound C3 convertases can bind a C3b molecule whereby the C5 convertases are formed. These cleave C5 into C5a and C5b, thus initiating the terminal pathway and leading to formation of the membrane attack complex (MAC). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood |
| + |
C3 | form complex
binding
|
C5 convertase complex (C3bBbC3b) |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263480 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26489954 |
In addition to the surface‐bound C3 convertase, a fluid‐phase convertase can be formed by association of water‐reacted C3, termed C3(H20), to FB thus constantly maintaining a low level of complement activation in solution (tick‐over). Both of the surface‐bound C3 convertases can bind a C3b molecule whereby the C5 convertases are formed. These cleave C5 into C5a and C5b, thus initiating the terminal pathway and leading to formation of the membrane attack complex (MAC). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood |
3.0
C5 convertase complex (C3bBbC3b)
CPX-5604