Relation Results

Summary

Name C5 convertase complex (C3bBbC3b)
Primary ID SIGNOR-C315
Links CPX-5604
Type complex
Formed by C3
Relations 4

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Type: Score: Layout: SPV 
0.5520.20.2C5 convertase complex (C3bBbC3b)C5C3 convertase complex (C3bBb)C3

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ C5 convertase complex (C3bBbC3b)up-regulates activity img/direct-activation.png cleavage C5 0.552
Identifier Residue Sequence Organism Cell Line
SIGNOR-263481 Arg677 KEILRPRrTLQKKIE Homo sapiens
pmid sentence
In addition to the surface‐bound C3 convertase, a fluid‐phase convertase can be formed by association of water‐reacted C3, termed C3(H20), to FB thus constantly maintaining a low level of complement activation in solution (tick‐over). Both of the surface‐bound C3 convertases can bind a C3b molecule whereby the C5 convertases are formed. These cleave C5 into C5a and C5b, thus initiating the terminal pathway and leading to formation of the membrane attack complex (MAC).
Identifier Residue Sequence Organism Cell Line
SIGNOR-263482 Arg751 HKDMQLGrLHMKTLL Homo sapiens
pmid sentence
In addition to the surface‐bound C3 convertase, a fluid‐phase convertase can be formed by association of water‐reacted C3, termed C3(H20), to FB thus constantly maintaining a low level of complement activation in solution (tick‐over). Both of the surface‐bound C3 convertases can bind a C3b molecule whereby the C5 convertases are formed. These cleave C5 into C5a and C5b, thus initiating the terminal pathway and leading to formation of the membrane attack complex (MAC).
Publications: 2 Organism: Homo Sapiens
Tissue: Blood
+ C3 convertase complex (C3bBb)form complex img/form-complex.png binding C5 convertase complex (C3bBbC3b) 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263479 Homo sapiens
pmid sentence
In addition to the surface‐bound C3 convertase, a fluid‐phase convertase can be formed by association of water‐reacted C3, termed C3(H20), to FB thus constantly maintaining a low level of complement activation in solution (tick‐over). Both of the surface‐bound C3 convertases can bind a C3b molecule whereby the C5 convertases are formed. These cleave C5 into C5a and C5b, thus initiating the terminal pathway and leading to formation of the membrane attack complex (MAC).
Publications: 1 Organism: Homo Sapiens
Tissue: Blood
+ C3form complex img/form-complex.png binding C5 convertase complex (C3bBbC3b) 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263480 Homo sapiens
pmid sentence
In addition to the surface‐bound C3 convertase, a fluid‐phase convertase can be formed by association of water‐reacted C3, termed C3(H20), to FB thus constantly maintaining a low level of complement activation in solution (tick‐over). Both of the surface‐bound C3 convertases can bind a C3b molecule whereby the C5 convertases are formed. These cleave C5 into C5a and C5b, thus initiating the terminal pathway and leading to formation of the membrane attack complex (MAC).
Publications: 1 Organism: Homo Sapiens
Tissue: Blood
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