| + |
PAX8 | up-regulates quantity by expression 
transcriptional regulation
|
TG |
0.478 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251998 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11786384 |
The transcription factor Pax8 plays an important role in the expression of the differentiated phenotype of thyroid follicular cells. It has recently been shown that Pax8 is necessary for thyroglobulin (Tg) gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
TG | up-regulates 
|
Colloid |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267135 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24251883 |
The thyroid gland is unique among endocrine glands in storing its principle hormonal product—the two very small thyroid hormones (TH)—as components of a 1000-fold larger precursor—thyroglobulin (Tg)—that is secreted and stored in the colloid, outside of the thyroid cell. Moreover, the thyroid cell is part of a layer of similar cells—the thyroid follicular epithelium—that completely encloses the secreted Tg and segregates it from the circulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
TG | up-regulates
|
Thyroid_hormonogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259915 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30886364 |
In humans, the thyroid hormones T3 and T4 are synthesized in the thyroid gland in a process that crucially involves the iodoglycoprotein thyroglobulin. The overall structure of thyroglobulin is conserved in all vertebrates. Upon thyroglobulin delivery from thyrocytes to the follicular lumen of the thyroid gland via the secretory pathway, multiple tyrosine residues can become iodinated to form mono-iodotyrosine (MIT) and/or di-iodotyrosine (DIT); however, selective tyrosine residues lead to preferential formation of T4 and T3 at distinct sites. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Tunica Interna Bulbi |
| Pathways: | Thyroid cancer |
| + |
APEX1 | up-regulates quantity by expression
transcriptional regulation
|
TG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271694 |
|
|
|
|
| pmid |
sentence |
| 9813166 |
In co-transfection experiments, Ref-1 increases the Pax-8 activating effect on thyroglobulin promoter. |
|
| Publications: |
1 |
| + |
TPO | up-regulates activity
catalytic activity
|
TG |
0.528 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259914 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23349248 |
After transport through the apical membrane, I− is covalently bound to the tyrosyl residues of Tg by thyroid peroxidase (TPO). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid cancer, Thyroid Hormone Metabolism |
3.0
TG
- 
- 