| + |
PAX8 | up-regulates quantity by expression 
transcriptional regulation
|
TG |
0.471 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251998 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11786384 |
The transcription factor Pax8 plays an important role in the expression of the differentiated phenotype of thyroid follicular cells. It has recently been shown that Pax8 is necessary for thyroglobulin (Tg) gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
WWTR1 | up-regulates
binding
|
PAX8 |
0.308 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182253 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19010321 |
Taz is a coactivator for pax8 and ttf-1, two transcription factors involved in thyroid differentiation. / we show that this interaction leads to a significant enhancement of the transcriptional activity of pax8 and ttf-1 on the thyroglobulin promoter thus suggesting a role of taz in the control of genes involved in thyroid development and differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Lung |
| Pathways: | Thyroid Hormone Metabolism |
| + |
TGFB1 | down-regulates activity 
binding
|
PAX8 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251993 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14623893 |
DNA Binding Activity of Pax8 to the NIS Promoter Is Reduced by Smad3. TGF-β decreases Pax8 DNA binding to the NIS promoter and also found a physical interaction between Pax8 and Smad3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
SMAD3 | down-regulates activity
binding
|
PAX8 |
0.373 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251992 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14623893 |
DNA Binding Activity of Pax8 to the NIS Promoter Is Reduced by Smad3. TGF-β decreases Pax8 DNA binding to the NIS promoter and also found a physical interaction between Pax8 and Smad3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
PAX8 | up-regulates quantity by expression 
transcriptional regulation
|
SLC3A1 |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254907 |
|
|
Homo sapiens |
Kidney |
| pmid |
sentence |
| 15673291 |
Expression of SLC3A1 mRNA was found to be tenfold higher in postnatal vs. fetal kidney; SLC3A1 expression is doubled by the proximal tubule transcription factor, PAX8. rBAT is expressed in the proximal convoluted and straight tubules in both fetal and adult kidney. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAX8 | up-regulates quantity by expression
transcriptional regulation
|
SLC5A5 |
0.419 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251990 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14623893 |
Pax8 has an essential role in thyroid organogenesis and differentiation, being the main mediator of thyroid gene transcription, including the NIS gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
PAX8 | up-regulates quantity by expression
transcriptional regulation
|
TPO |
0.41 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267277 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27347897 |
TSH regulates TPO expression through the cAMP pathway and acts with thyroid-specific transcription factors such as TTF-1, TTF-2 and Pax-8. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Hypophysis |
| Pathways: | Thyroid Hormone Metabolism |
3.0
PAX8
- 
- 