| + |
PTH | up-regulates 
binding
|
PTH1R |
0.764 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182039 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18981475 |
Here we show that binding of pth to its receptor pth1r induced association of lrp6, a coreceptor of wnt, with pth1r. The formation of the ternary complex containing pth, pth1r, and lrp6 promoted rapid phosphorylation of lrp6, which resulted in the recruitment of axin to lrp6, and stabilization of beta-catenin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GCM2 | up-regulates quantity by expression 
transcriptional regulation
|
PTH |
0.419 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254200 |
|
|
Homo sapiens |
Parathyroid Hormone Secreting Cell |
| pmid |
sentence |
| 20558332 |
We found that GCMB binds to the PTH gene 5'-promoter (-390/-383 bp) and positively regulates its transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTH | up-regulates quantity by expression
transcriptional regulation
|
MMP13 |
0.46 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254234 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17656568 |
Parathyroid hormone (PTH) functions as an essential regulator of calcium homeostasis and as a mediator of bone remodeling. We have already shown that PTH stimulates the expression of matrix metalloproteinase-13 (MMP-13), which is responsible for degrading components of extracellular matrix. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTH | up-regulates
binding
|
PTH2R |
0.688 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-115104 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11861531 |
Pth was shown to efficiently activate the human type 2 pth receptor (pth2 receptor) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain, Kidney |
3.0
PTH
- 
- 