Summary

Name HLA-DRA
Full Name HLA class II histocompatibility antigen, DR alpha chain
Synonyms MHC class II antigen DRA | HLA-DRA1
Primary ID P01903
Links - -
Type protein
Relations 9
Pathways EBV infection
Function An alpha chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the beta chain HLA-DRB, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DR-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells (PubMed:29884618, PubMed:17334368, PubMed:8145819, PubMed:15322540, PubMed:22327072, PubMed:27591323, PubMed:31495665, PubMed:15265931, PubMed:9075930, PubMed:24190431). Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:8145819). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (PubMed:31495665). Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance (PubMed:17182262, PubMed:23783831). The selection of the immunodominant epitopes follows two processing modes

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ MARCHF8down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination HLA-DRA 0.2
Publications: 1 Organism: Homo Sapiens
+ MARCHF1down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination HLA-DRA 0.2
Publications: 1 Organism: Homo Sapiens
+ RFX complexup-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DRA 0.415
Publications: 2 Organism: In Vitro, Homo Sapiens
+ HLA-DRAup-regulates img/indirect-activation.png Membrane_fusion 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ NFX1down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation HLA-DRA 0.398
Publications: 1 Organism: Homo Sapiens
+ RFX5up-regulates quantity by expression img/direct-activation.png transcriptional regulation HLA-DRA 0.502
Publications: 1 Organism: Homo Sapiens
+ EBV gH:gL:gp42up-regulates activity img/direct-activation.png binding HLA-DRA 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ CIITAup-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DRA 0.621
Publications: 1 Organism: Homo Sapiens