| + |
CTDSPL2 | up-regulates quantity by expression 
transcriptional regulation
|
HBE1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251779 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20932329 |
CTD small phosphatase like 2 (CTDSPL2) can increase ε- and γ-globin gene expression in K562 cells and CD34+ cells derived from umbilical cord blood. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFE2 | up-regulates quantity by expression
transcriptional regulation
|
HBE1 |
0.477 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251842 |
|
|
Mus musculus |
Erythroleukemia Cell |
| pmid |
sentence |
| 16287851 |
NF-E2 is a transcription activator for the regulation of a number of erythroid- and megakaryocytic lineage-specific genes. Here we present evidence that the large subunit of mammalian NF-E2, p45, is sumoylated in vivo in human erythroid K562 cells. we demonstrated by stable transfection assay that only the wild-type p45, but not its mutant form p45 (K368R), could efficiently rescue β-globin gene expression in the p45-null, erythroid cell line CB3. These data together point to a model of mammalian β-like globin gene activation by sumoylated p45/NF-E2 in erythroid cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
KLF11 | up-regulates quantity by expression
transcriptional regulation
|
HBE1 |
0.284 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251829 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10207080 |
Transfection of K562 cells with FKLF cDNA enhanced the expression of the endogenous epsilon- and gamma-globin genes, suggesting an in vivo role of FKLF in fetal and embryonic globin gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLF2 | up-regulates quantity by expression
transcriptional regulation
|
HBE1 |
0.247 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251830 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15947087 |
Our results show that KLF2 positively regulates the human (ε) and murine (Ey and βh1) embryonic globin genes at both E10.5 and E12.5, in the yolk sac, which is the site of primitive erythropoiesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
HBE1
- 
- 