Relation Results

Summary

Name HBE1
Full Name Hemoglobin subunit epsilon
Synonyms Epsilon-globin, Hemoglobin epsilon chain | HBE
Primary ID P02100
Links - -
Type protein
Relations 4
Function The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.

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Type: Score: Layout: SPV 
0.2790.20.4970.244KLF11HBE1CTDSPL2NFE2KLF2

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Relations
Regulator
Mechanism
target
score ℹ
+ KLF11up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HBE1 0.279
Identifier Residue Sequence Organism Cell Line
SIGNOR-251829 Homo sapiens
pmid sentence
Transfection of K562 cells with FKLF cDNA enhanced the expression of the endogenous epsilon- and gamma-globin genes, suggesting an in vivo role of FKLF in fetal and embryonic globin gene expression.
Publications: 1 Organism: Homo Sapiens
+ CTDSPL2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HBE1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-251779 Homo sapiens
pmid sentence
CTD small phosphatase like 2 (CTDSPL2) can increase ε- and γ-globin gene expression in K562 cells and CD34+ cells derived from umbilical cord blood.
Publications: 1 Organism: Homo Sapiens
+ NFE2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HBE1 0.497
Identifier Residue Sequence Organism Cell Line
SIGNOR-251842 Mus musculus Erythroleukemia Cell
pmid sentence
NF-E2 is a transcription activator for the regulation of a number of erythroid- and megakaryocytic lineage-specific genes. Here we present evidence that the large subunit of mammalian NF-E2, p45, is sumoylated in vivo in human erythroid K562 cells. we demonstrated by stable transfection assay that only the wild-type p45, but not its mutant form p45 (K368R), could efficiently rescue β-globin gene expression in the p45-null, erythroid cell line CB3. These data together point to a model of mammalian β-like globin gene activation by sumoylated p45/NF-E2 in erythroid cells.
Publications: 1 Organism: Mus Musculus
+ KLF2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HBE1 0.244
Identifier Residue Sequence Organism Cell Line
SIGNOR-251830 Mus musculus
pmid sentence
Our results show that KLF2 positively regulates the human (ε) and murine (Ey and βh1) embryonic globin genes at both E10.5 and E12.5, in the yolk sac, which is the site of primitive erythropoiesis.
Publications: 1 Organism: Mus Musculus
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