Summary

Name EBNA1
Full Name Epstein-Barr nuclear antigen 1
Synonyms EBNA-1, EBV nuclear antigen 1 |
Primary ID P03211
Links - -
Type protein
Relations 4
Pathways EBV infection
Function Plays an essential role in replication and partitioning of viral genomic DNA during latent viral infection. During this phase, the circular double-stranded viral DNA undergoes replication once per cell cycle and is efficiently partitioned to the daughter cells. EBNA1 activates the initiation of viral DNA replication through binding to specific sites in the viral latent origin of replication, oriP. Additionally, it governs the segregation of viral episomes by mediating their attachment to host cell metaphase chromosomes. Also activates the transcription of several viral latency genes. Finally, it can counteract the stabilization of host p53/TP53 by host USP7, thereby decreasing apoptosis and increasing host cell survival.

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation EBNA1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation STAT1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ down-regulates quantity img/indirect_inhibition.png destabilization SMAD2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ down-regulates activity img/indirect_inhibition.png IKK-complex 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection