| + |
IKK-complex | down-regulates 
phosphorylation
|
NCOR2 |
0.418 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216393 |
Ser2407 |
AKVSGRPsSRKAKSP |
Homo sapiens |
|
| pmid |
sentence |
| 15494311 |
Nf-kappab transcription requires ikkalpha to phosphorylate smrt on chromatin, stimulating the exchange of corepressor for coactivator complexes. Ikk directly phosphorylates smrt to stimulate nuclear export. Ikkalpha orchestrates smrt derepression, a prerequisite for nf-kappab transcription and survival. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKK-complex | down-regulates activity
phosphorylation
|
BAD |
0.266 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209776 |
Ser25 |
AERGLGPsPAGDGPS |
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 23332762 |
Ikk phosphorylates bad at serine-26 (ser26) and primes it for inactivation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | COVID-19 Causal Network, FLT3-ITD signaling, Inhibition of Apoptosis |
| + |
IKK-complex | down-regulates
phosphorylation
|
NFKBIA |
0.885 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216385 |
Ser32 |
LLDDRHDsGLDSMKD |
Homo sapiens |
|
| pmid |
sentence |
| 9346241 |
We described the purification of a 900 kda protein kinase complex, the ikb kinase (ikk), that phosphorylates ikbalfa and ikbbeta at the sites that mediate their ubiquitination and degradation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216389 |
Ser36 |
RHDSGLDsMKDEEYE |
Homo sapiens |
|
| pmid |
sentence |
| 9346241 |
We described the purification of a 900 kda protein kinase complex, the ikb kinase (ikk), that phosphorylates ikbalfa and ikbbeta at the sites that mediate their ubiquitination and degradation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216396 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21232017 |
Tak1 become activated and then phosphorilates and activates ikk2 which in turn now phosphorylates ikba, marking it for k48-ubiquitination and proteasomal degradation |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EBV infection, FLT3-ITD signaling, IL1 Signaling , Inhibition of Apoptosis, Multiple sclerosis, NF-KB Canonical, Pancreatic ductal adenocarcinoma (PDA), TNF-alpha Signaling, T cell activation, Toll like receptors |
| + |
IKK-complex | down-regulates quantity by destabilization
phosphorylation
|
NFKBIA |
0.885 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209773 |
Ser36 |
RHDSGLDsMKDEEYE |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9346241 |
We described the purification of a 900 kda protein kinase complex, the ikb kinase (ikk), that phosphorylates ikbalfa and ikbbeta at the sites that mediate their ubiquitination and degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EBV infection, FLT3-ITD signaling, IL1 Signaling , Inhibition of Apoptosis, Multiple sclerosis, NF-KB Canonical, Pancreatic ductal adenocarcinoma (PDA), TNF-alpha Signaling, T cell activation, Toll like receptors |
| + |
IKK-complex |
phosphorylation
|
IKBKG |
0.928 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209792 |
Ser376 |
PPAPAYLsSPLALPS |
Homo sapiens |
|
| pmid |
sentence |
| 12657630 |
Phosphopeptide-mapping experiments with metabolically radiolabeled cells indicate that ikkbeta phosphorylates human ikkgamma at ser-31, ser-43, and ser-376 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216403 |
Ser43 |
PAMLHLPsEQGAPET |
Homo sapiens |
|
| pmid |
sentence |
| 17977820 |
In this study we analyze the ikkbeta-mediated phosphorylation of the ikk-binding domain of nemo. In vitro, ikkbeta phosphorylates three serine residues in the domain of nemo at positions 43, 68, and 85. However, mutational analysis revealed that only the phosphorylation of serine 68 in the center of the ikk-binding domain plays an essential role for the formation and the function of the ikk complex. Thus, ser(68) phosphorylation attenuates the amino-terminal dimerization of nemo as well as the ikkbeta-nemo interaction. I |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, IL1 Signaling , Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors |
| + |
IKK-complex | down-regulates activity
phosphorylation
|
CYLD |
0.615 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266435 |
Ser418 |
TTENRFHsLPFSLTK |
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 15870263 |
In response to cellular stimuli, CYLD undergoes rapid and transient phosphorylation, which is required for signal-induced TRAF2 ubiquitination and activation of downstream signaling events. Interestingly, the CYLD phosphorylation requires IkappaB kinase gamma (IKKgamma) and can be induced by IKK catalytic subunits. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NF-KB Canonical |
| + |
IKK-complex | down-regulates activity
phosphorylation
|
MTURN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273641 |
Ser58 |
GDNFHVWsESEDCLP |
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 28704656 |
Here we report that viral infection induced upregulation of INKIT, an inhibitor for NF-κB and IRF3 that restricted innate antiviral responses by blocking phosphorylation of p65 and IRF3. Viral infection induced IKK-mediated phosphorylation of INKIT at Ser58, resulting in its dissociation from the IKKs. INKIT is associated with IKKα/β and TBK1/IKKɛ and inhibits the recruitment and phosphorylation of p65 and IRF3, respectively. IKKα and TBK1 phosphorylate INKIT at Ser58, which results in disassociation of INKIT from IKKα or TBK1 and thereby allows for the subsequent recruitment and phosphorylation of p65 and IRF3 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
IKK-complex | down-regulates
phosphorylation
|
FOXO3 |
0.534 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216407 |
Ser644 |
GLDFNFDsLISTQNV |
Homo sapiens |
|
| pmid |
sentence |
| 15084260 |
Ikappab kinase promotes tumorigenesis through inhibition of forkhead foxo3a. The tnf treatment of ht-29 cells increased ikk-dependent foxo3 ser644 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Inhibition of Apoptosis |
| + |
IKK-complex | down-regulates
phosphorylation
|
FOXO |
0.536 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252950 |
Ser644 |
GLDFNFDsLISTQNV |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 15084260 |
Ikappab kinase promotes tumorigenesis through inhibition of forkhead foxo3a. The tnf treatment of ht-29 cells increased ikk-dependent foxo3 ser644 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
IKK-complex | down-regulates quantity by destabilization
phosphorylation
|
FOXO |
0.536 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252951 |
Ser644 |
GLDFNFDsLISTQNV |
Homo sapiens |
|
| pmid |
sentence |
| 19188143 |
Ikkbeta phosphorylates foxo3a at ser644. Ikappab kinase (ikk) physically interacts with, phosphorylates, and inhibits foxo3a independent of akt and causes proteolysis of foxo3a via the ub-dependent proteasome pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
IKK-complex | down-regulates quantity by destabilization
phosphorylation
|
FOXO3 |
0.534 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209769 |
Ser644 |
GLDFNFDsLISTQNV |
Homo sapiens |
|
| pmid |
sentence |
| 19188143 |
Ikkbeta phosphorylates foxo3a at ser644. Ikappab kinase (ikk) physically interacts with, phosphorylates, and inhibits foxo3a independent of akt and causes proteolysis of foxo3a via the ub-dependent proteasome pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Inhibition of Apoptosis |
| + |
IKK-complex | down-regulates activity
phosphorylation
|
IKBKG |
0.928 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209788 |
Ser68 |
LRDAIRQsNQILRER |
Homo sapiens |
|
| pmid |
sentence |
| 17977820 |
In this study we analyze the ikkbeta-mediated phosphorylation of the ikk-binding domain of nemo. In vitro, ikkbeta phosphorylates three serine residues in the domain of nemo at positions 43, 68, and 85. However, mutational analysis revealed that only the phosphorylation of serine 68 in the center of the ikk-binding domain plays an essential role for the formation and the function of the ikk complex. Thus, ser(68) phosphorylation attenuates the amino-terminal dimerization of nemo as well as the ikkbeta-nemo interaction. I |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209784 |
Ser85 |
ELLHFQAsQREEKEF |
Homo sapiens |
|
| pmid |
sentence |
| 17977820 |
In this study we analyze the ikkbeta-mediated phosphorylation of the ikk-binding domain of nemo. In vitro, ikkbeta phosphorylates three serine residues in the domain of nemo at positions 43, 68, and 85. However, mutational analysis revealed that only the phosphorylation of serine 68 in the center of the ikk-binding domain plays an essential role for the formation and the function of the ikk complex. Thus, ser(68) phosphorylation attenuates the amino-terminal dimerization of nemo as well as the ikkbeta-nemo interaction. I |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, IL1 Signaling , Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors |
| + |
IKBKG | form complex 
binding
|
IKK-complex |
0.928 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209762 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19666475 |
Proinflammatory NF-kappaB activation requires the IkappaB (inhibitor of NF-kappaB) kinase (IKK) complex that contains two catalytic subunits named IKKalpha and IKKbeta and a regulatory subunit named NF-kappaB essential modulator (NEMO). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217436 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12192055 |
The n-terminal domain of ikkgamma is required both for the binding of ikkalfa and ikkbeta and their assembly into a high-molecular-weight complex essential for activation |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| Pathways: | EBV infection, IL1 Signaling , Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors |
| + |
IKK-complex | up-regulates quantity by expression 
|
HES1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253586 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22056382 |
Tnf-α enhanced the transcriptional activity of a classical Notch target gene via Ikk2 by inducing histone H3 phosphorylation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT2 | up-regulates 
phosphorylation
|
IKK-complex |
0.438 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217463 |
|
|
Homo sapiens |
Thymoma Cell |
| pmid |
sentence |
| 19609947 |
Although there are likely to be multiple levels of crosstalk between the pi3k-akt and nf-kb pathways, one mechanism has been attributed to direct phosphorylation of the amino acid residue t23 on ikb kinase alfa (ikkalfa) by akt, thereby leading to activation of this kinase upstream of nf-kb akt mediates ikkalpha phosphorylation at threonine 23 akt transiently associates in vivo with ikk and induces ikk activation. Akt mediates ikkalfa phosphorylation at threonine 23.Akt phosphorylates ikkalpha on t23, and this phosphorylation event is a prerequisite for the phosphorylation of p65 at s534 by ikkalpha and beta |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K7 | up-regulates
phosphorylation
|
IKK-complex |
0.717 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217445 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11460167 |
Tak1 kinase complex phosphorylates and activates ikk in a manner that depends on traf6 and ubc13-uev1a |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EBV infection, IL1 Signaling , Inflammosome Activation, Inhibition of Apoptosis, NF-KB Canonical, SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors |
| + |
MAP3K7 | up-regulates activity
phosphorylation
|
IKK-complex |
0.717 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209759 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21232017 |
Tak1 become activated and then phosphorilates and activates ikk2 whic in turn now phosphorylates ikba, marking it for k48-ubiquitination and proteasomal degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256024 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21133840 |
RIP-1 recruitment of MEKK-3 and transforming growth factor-beta (TGFbeta)-activated kinase (TAK1) subsequently activates the IKK (inhibitor of κB kinase) complex |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EBV infection, IL1 Signaling , Inflammosome Activation, Inhibition of Apoptosis, NF-KB Canonical, SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors |
| + |
MAP3K14 | up-regulates
phosphorylation
|
IKK-complex |
0.712 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217433 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9520446 |
Nf-kappab-inducing kinase activates ikk-alpha by phosphorylation of ser-176.Nik preferentially phosphorylates ikk-alpha over ikk-beta, leading to the activation of ikk-alpha kinase activity; the accumulated nik phosphorylates ikkalfa. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Innate Immune Response, NF-KB Non Canonical |
| + |
CHUK | form complex
binding
|
IKK-complex |
0.774 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164506 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20300203 |
The kinase(s) responsible for the phosphorylation of the ikb inhibitors remained elusive for many years, until the biochemical purification of a cytoplasmic high-molecular weight complex migrating around 700900 kda and containing two related catalytic subunits, ikkalfa and ikkbeta. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NF-KB Non Canonical |
| + |
PRKAA2 | up-regulates
phosphorylation
|
IKK-complex |
0.258 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217457 |
|
|
Homo sapiens |
Monocyte |
| pmid |
sentence |
| 21673972 |
These results demonstrate that the ikk is a direct substrate of ampk_2 and that its phosphorylation on ser177 and ser181no initiates the activation of the ampk_2 in endothelial cells which in turn phosphorylates and activates the _-subunit of the ikk. The latter also induces a higher rate of ikk auto-inactivation and thus attenuates the activation of nf_b and the expression of inflammatory genes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRC | up-regulates
phosphorylation
|
IKK-complex |
0.384 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217442 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12707358 |
These results indicate that c-src can associate with ikkbeta and phosphorylate its tyrosine residues after tnf-alfa or tpa stimulation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217439 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12645577 |
These results indicate that c-src can associate with ikkbeta and phosphorylate its tyrosine residues after tnf-alfa or tpa stimulation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
AKT1 | up-regulates
phosphorylation
|
IKK-complex |
0.643 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217460 |
|
|
Homo sapiens |
Thymoma Cell |
| pmid |
sentence |
| 19609947 |
Although there are likely to be multiple levels of crosstalk between the pi3k-akt and nf-kb pathways, one mechanism has been attributed to direct phosphorylation of the amino acid residue t23 on ikb kinase alfa (ikkalfa) by akt, thereby leading to activation of this kinase upstream of nf-kb akt mediates ikkalpha phosphorylation at threonine 23 akt transiently associates in vivo with ikk and induces ikk activation. Akt mediates ikkalfa phosphorylation at threonine 23.Akt phosphorylates ikkalpha on t23, and this phosphorylation event is a prerequisite for the phosphorylation of p65 at s534 by ikkalpha and beta |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
ERC1 | up-regulates
binding
|
IKK-complex |
0.594 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217448 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15218148 |
Elks likely functions by recruiting ikappabalpha to the ikk complex and thus serves a regulatory function for ikk activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MTURN | down-regulates activity
binding
|
IKK-complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273663 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 28704656 |
Here we report that viral infection induced upregulation of INKIT, an inhibitor for NF-κB and IRF3 that restricted innate antiviral responses by blocking phosphorylation of p65 and IRF3. Viral infection induced IKK-mediated phosphorylation of INKIT at Ser58, resulting in its dissociation from the IKKs. INKIT is associated with IKKα/β and TBK1/IKKɛ and inhibits the recruitment and phosphorylation of p65 and IRF3, respectively. IKKα and TBK1 phosphorylate INKIT at Ser58, which results in disassociation of INKIT from IKKα or TBK1 and thereby allows for the subsequent recruitment and phosphorylation of p65 and IRF3 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
RUNX1 | down-regulates activity
binding
|
IKK-complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255690 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22021368 |
We found that AML1 inhibits NF-κB signaling through interaction with IκB kinase complex in the cytoplasm. Remarkably, AML1 mutants found in myeloid tumors lack the ability to inhibit NF-κB signaling, and human cases with AML1-related leukemia exhibits distinctly activated NF-κB signaling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKBKB | form complex
binding
|
IKK-complex |
0.808 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164509 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20300203 |
The kinase(s) responsible for the phosphorylation of the ikb inhibitors remained elusive for many years, until the biochemical purification of a cytoplasmic high-molecular weight complex migrating around 700900 kda and containing two related catalytic subunits, ikkalfa and ikkbeta. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
IKK-complex | down-regulates
phosphorylation
|
IKK-complex |
0.837 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216373 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10195894 |
Once activated, ikkbeta autophosphorylated at a carboxyl-terminal serine cluster. Such phosphorylation decreased ikk activity and may prevent prolonged activation of the inflammatory response |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation, COVID-19 Causal Network, EBV infection, FLT3-ITD signaling, Innate Immune Response, IL1 Signaling , Inflammosome Activation, Inhibition of Apoptosis, Macrophage polarization, Multiple sclerosis, NF-KB Canonical, NF-KB Non Canonical, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA, TNF-alpha Signaling, T cell activation, Toll like receptors |
| + |
IKK-complex | up-regulates
phosphorylation
|
NfKb-p65/p50 |
0.812 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216341 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15489227 |
Chromatographic fractionation of cell extracts allowed the identification of two distinct enzymatic activities phosphorylating ser-536. Peak 1 represents an unknown kinase, whereas peak 2 contained ikkalpha, ikkbeta, ikkepsilon, and tbk1. collectively, our results provide evidence for at least five kinases that converge on ser-536 of p65 and a novel function for this phosphorylation site in the recruitment of components of the basal transcriptional machinery to the interleukin-8 promoter. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216365 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19609947 |
Our data suggest that the stimulation of nfkb by akt is dependent on the phosphorylation of p65 at s534, mediated by ikk (ikb kinase) alfa and beta. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation, COVID-19 Causal Network, EBV infection, FLT3-ITD signaling, Innate Immune Response, IL1 Signaling , Inflammosome Activation, Inhibition of Apoptosis, Macrophage polarization, Multiple sclerosis, NF-KB Canonical, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA, TNF-alpha Signaling, T cell activation, Toll like receptors |
| + |
IKK-complex | down-regulates
phosphorylation
|
BAD |
0.266 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216399 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23332762 |
Ikk phosphorylates bad at serine-26 (ser26) and primes it for inactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, FLT3-ITD signaling, Inhibition of Apoptosis |
| + |
AKT | up-regulates
phosphorylation
|
IKK-complex |
0.643 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244281 |
|
|
Homo sapiens |
Thymoma Cell |
| pmid |
sentence |
| 19609947 |
Although there are likely to be multiple levels of crosstalk between the pi3k-akt and nf-kb pathways, one mechanism has been attributed to direct phosphorylation of the amino acid residue t23 on ikb kinase alfa (ikkalfa) by akt, thereby leading to activation of this kinase upstream of nf-kb akt mediates ikkalpha phosphorylation at threonine 23 akt transiently associates in vivo with ikk and induces ikk activation. Akt mediates ikkalfa phosphorylation at threonine 23.Akt phosphorylates ikkalpha on t23, and this phosphorylation event is a prerequisite for the phosphorylation of p65 at s534 by ikkalpha and beta |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation, COVID-19 Causal Network, EBV infection, FLT3-ITD signaling, Inflammosome Activation, Inhibition of Apoptosis, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV INFLAMMATORY RESPONSE, T cell activation |
| + |
RIPK1 | up-regulates activity
binding
|
IKK-complex |
0.662 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-245026 |
|
|
Mus musculus |
Fibroblast |
| pmid |
sentence |
| 10795740 |
We found that TNF-R1-mediated IKK activation requires both RIP and TRAF2 proteins. Although TRAF2 or RIP can be independently recruited to the TNF-R1 complex, neither one of them alone is capable of transducing the TNF signal that leads to IKK activation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, Macrophage polarization, Multiple sclerosis, NF-KB Canonical, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA, TNF-alpha Signaling |
| + |
EBNA1 | down-regulates activity 
|
IKK-complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266802 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29659505 |
EBNA1 has been reported to block p65 activation by inhibiting IKKα/β through an unknown mechanism, we suggest that, in NPC, NF-κB signaling and EBNA1 may form a regulatory loop which supports EBV latent gene expression, while also limiting NF-κB activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection |
| + |
M | down-regulates activity
binding
|
IKK-complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260261 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 17705188 |
Together, these results indicate that SARS-CoV M suppresses NF-kappaB activity probably through a direct interaction with IKKbeta, resulting in lower Cox-2 expression. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | COVID-19 Causal Network, SARS-CoV INFLAMMATORY RESPONSE |
| + |
AKT3 | up-regulates
phosphorylation
|
IKK-complex |
0.396 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217466 |
|
|
Homo sapiens |
Thymoma Cell |
| pmid |
sentence |
| 19609947 |
Although there are likely to be multiple levels of crosstalk between the pi3k-akt and nf-kb pathways, one mechanism has been attributed to direct phosphorylation of the amino acid residue t23 on ikb kinase alfa (ikkalfa) by akt, thereby leading to activation of this kinase upstream of nf-kb akt mediates ikkalpha phosphorylation at threonine 23 akt transiently associates in vivo with ikk and induces ikk activation. Akt mediates ikkalfa phosphorylation at threonine 23.Akt phosphorylates ikkalpha on t23, and this phosphorylation event is a prerequisite for the phosphorylation of p65 at s534 by ikkalpha and beta |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
IKK-complex
CPX-3269