| + |
PROC | down-regulates activity 
cleavage
|
F5 |
0.578 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263628 |
Arg334 |
KNCPKKTrNLKKITR |
in vitro |
|
| pmid |
sentence |
| 7989361 |
The mechanism of inactivation of human factor V and human factor Va by activated protein C|Membrane-bound human factor V (250 nM) is cleaved by APC (2.5 nM) to give M(r) = 200,000, 70,000, 45,000, and 30,000 fragments and an M(r) = 22/20,000 doublet. These fragments are released after four sequential cleavages of the membrane-bound procofactor at Arg306, Arg506, Arg679, and Lys994. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263629 |
Arg534 |
KSRSLDRrGIQRAAD |
in vitro |
|
| pmid |
sentence |
| 7989361 |
The mechanism of inactivation of human factor V and human factor Va by activated protein C|Membrane-bound human factor V (250 nM) is cleaved by APC (2.5 nM) to give M(r) = 200,000, 70,000, 45,000, and 30,000 fragments and an M(r) = 22/20,000 doublet. These fragments are released after four sequential cleavages of the membrane-bound procofactor at Arg306, Arg506, Arg679, and Lys994. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263630 |
Arg707 |
ESTVMATrKMHDRLE |
in vitro |
|
| pmid |
sentence |
| 7989361 |
The mechanism of inactivation of human factor V and human factor Va by activated protein C|Membrane-bound human factor V (250 nM) is cleaved by APC (2.5 nM) to give M(r) = 200,000, 70,000, 45,000, and 30,000 fragments and an M(r) = 22/20,000 doublet. These fragments are released after four sequential cleavages of the membrane-bound procofactor at Arg306, Arg506, Arg679, and Lys994. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263627 |
Lys1022 |
GGKSRLKkSQFLIKT |
in vitro |
|
| pmid |
sentence |
| 7989361 |
The mechanism of inactivation of human factor V and human factor Va by activated protein C|Membrane-bound human factor V (250 nM) is cleaved by APC (2.5 nM) to give M(r) = 200,000, 70,000, 45,000, and 30,000 fragments and an M(r) = 22/20,000 doublet. These fragments are released after four sequential cleavages of the membrane-bound procofactor at Arg306, Arg506, Arg679, and Lys994. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263528 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29880919 |
Activated protein C (APC), which cleaves and inactivates both FVIIIa and FVa, thereby shutting down both the tenase and prothrombinase complexes |
|
| Publications: |
5 |
Organism: |
In Vitro, Homo Sapiens |
| Tissue: |
Blood Plasma |
| + |
GGCX | up-regulates activity 
carboxylation
|
PROC |
0.548 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265925 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28125048 |
Gamma-carboxylation is essential in the activation and proper functioning of multiple VK-dependent proteins (VKDP), the most well-known of which are involved in blood clotting, including coagulation factors (FII, FVII, FIX and FX) and natural anti-clotting agents (protein C, protein S (ProS; OMIM*176880) and protein Z |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Vitamin-K cycle |
| + |
PROC | down-regulates activity
cleavage
|
F7 |
0.239 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263527 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29880919 |
Activated protein C (APC), which cleaves and inactivates both FVIIIa and FVa, thereby shutting down both the tenase and prothrombinase complexes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood Plasma |
| Pathways: | Vitamin-K cycle |
| + |
Thrombin-Thrombomodulin | up-regulates activity
cleavage
|
PROC |
0.704 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263526 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29880919 |
Thrombin also activates the negative regulators of the cascade, after complexing with thrombomodulin (TM) and endothelial protein C receptor (EPCR), to activate protein C (PC) to activated PC (APC). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood Plasma |
3.0
PROC
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- 