| + |
NFATC3 | up-regulates quantity by expression 
transcriptional regulation
|
TFF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254639 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16219765 |
Overexpression of NFAT3 enhanced both ERalpha and ERbeta transcriptional activities in a ligand-independent manner and up-regulated downstream estrogen-responsive genes including pS2 and cathepsin D. Reduction of endogenous NFAT3 with NFAT3 small interfering RNA or overexpression of NFAT3 deletion mutants that lack the ER-binding sites reduced the NFAT3 coactivation of ERalpha and ERbeta. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BRCA1 | down-regulates quantity by repression 
transcriptional regulation
|
TFF1 |
0.304 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253937 |
|
|
Homo sapiens |
Breast Cancer Cell Line, Prostate Cancer Cell Line |
| pmid |
sentence |
| 11244506 |
In addition, BRCA1 blocked the expression of two endogenous estrogen-regulated gene products in human breast cancer cells: pS2 and cathepsin D. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AIP | down-regulates quantity by repression 
transcriptional regulation
|
TFF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259911 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21984905 |
We show that XAP2 is recruited to the promoter of ERα regulated genes like the breast cancer marker gene pS2 or GREB1 and negatively regulate the expression of these genes in MCF-7 cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253643 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 21984905 |
In this study, we show that XAP2 is recruited to the promoter of ERα regulated genes like the breast cancer marker gene pS2 or GREB1 and negatively regulate the expression of these genes in MCF-7 cells. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ESR2 | up-regulates quantity by expression
transcriptional regulation
|
TFF1 |
0.359 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253939 |
|
|
Homo sapiens |
Breast Cancer Cell Line |
| pmid |
sentence |
| 11517191 |
ER beta and ER alpha induced the expression of several endogenous genes such as pS2, TGF alpha, or the cyclin kinase inhibitor p21 but, in contrast to ER alpha, ER beta was unable to regulate c-myc proto-oncogene expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
TFF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254572 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 15870696 |
Valproate (VPA) induces silencing of the ERalpha, cyclin D1 and pS2 promoters. Chromatin immunoprecipitation (ChIP) analysis demonstrates that VPA induces recruitment of the 5-MeCpG binding protein MeCP2 to the ERalpha A promoter and also to the pS2 and cyclin D1 promoters |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ESR1 | up-regulates quantity by expression
transcriptional regulation
|
TFF1 |
0.745 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253938 |
|
|
Homo sapiens |
Breast Cancer Cell Line |
| pmid |
sentence |
| 11517191 |
ER beta and ER alpha induced the expression of several endogenous genes such as pS2, TGF alpha, or the cyclin kinase inhibitor p21 but, in contrast to ER alpha, ER beta was unable to regulate c-myc proto-oncogene expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TFF1
- 
- 