+ |
PRKCA | down-regulates activity
phosphorylation
|
ATP1A1 |
0.335 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262941 |
Ser16 |
KYEPAAVsEQGDKKG |
Mycolicibacterium chitae |
OK Cell |
pmid |
sentence |
14976217 |
Parathyroid hormone (PTH) inhibits Na+,K+-ATPase activity through protein kinase C- (PKC) and extracellular signal-regulated kinase- (ERK) dependent pathways and increases serine phosphorylation of the α1-subunit. These results suggest that PTH regulates Na(+),K(+)-ATPase by PKC and ERK-dependent alpha(1)-subunit phosphorylation and that the phosphorylation requires the expression of a serine at the 11 position of the Na(+),K(+)-ATPase alpha(1)-subunit. |
|
Publications: |
1 |
Organism: |
Mycolicibacterium Chitae |
+ |
MAPK1 | down-regulates activity
phosphorylation
|
ATP1A1 |
0.509 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262940 |
Ser16 |
KYEPAAVsEQGDKKG |
Mycolicibacterium chitae |
OK Cell |
pmid |
sentence |
14976217 |
Parathyroid hormone (PTH) inhibits Na+,K+-ATPase activity through protein kinase C- (PKC) and extracellular signal-regulated kinase- (ERK) dependent pathways and increases serine phosphorylation of the α1-subunit. These results suggest that PTH regulates Na(+),K(+)-ATPase by PKC and ERK-dependent alpha(1)-subunit phosphorylation and that the phosphorylation requires the expression of a serine at the 11 position of the Na(+),K(+)-ATPase alpha(1)-subunit. |
|
Publications: |
1 |
Organism: |
Mycolicibacterium Chitae |
+ |
PRKCZ | up-regulates activity
phosphorylation
|
ATP1A1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263181 |
Ser16 |
KYEPAAVsEQGDKKG |
Homo sapiens |
A-549 Cell |
pmid |
sentence |
12671055 |
Na,K-ATPase alpha(1) subunit was phosphorylated by PKC in hypoxia-treated AEC. In AEC treated with a PKC-zeta antagonist peptide or with the Na,K-ATPase alpha(1) subunit lacking the PKC phosphorylation site (Ser-18), hypoxia failed to decrease Na,K-ATPase abundance and function. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |