| + |
KRT1 | up-regulates quantity 
binding
|
MPO |
0.249 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251886 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17591979 |
CK1 and CK9 specifically bind MPO. MPO is internalized by endothelial cells through a direct interaction with the endothelial surface protein CK1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MPO | up-regulates activity
binding
|
MPO-ANCA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270585 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15972951 |
Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome, and idiopathic pauci-immune necrotizing crescentic glomerulonephritis are associated with myeloperoxidase (MPO)-specific anti-neutrophil cytoplasmic autoantibodies (ANCAs). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood Serum |
| + |
MPO | down-regulates activity 
oxidation
|
APOA1 |
0.418 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252102 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20043647 |
When apolipoprotein A-I (apoA-I), the major HDL protein, was oxidized by MPO, its ability to promote cellular cholesterol efflux by ABCA1 was impaired. Moreover, oxidized apoA-I was unable to activate lecithin:cholesterol acyltransferase (LCAT), which rapidly converts free cholesterol to cholesteryl ester, a critical step in HDL maturation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MPO
- 
- 