| + |
FGF1 | up-regulates 
binding
|
FGFR4 |
0.819 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-18454 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1385111 |
Our results establish an fgf binding profile for fgfr-4 with afgf having the highest affinity, followed by k-fgf/hst-1 and bfgf. In addition, fgf-6 was found to bind to fgfr-4 in ligand competition experiments. Ligands binding to fgfr-4 induced receptor autophosphorylation and phosphorylation of a set of cellular polypeptides. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rhabdomyosarcoma |
| + |
FGF1 | up-regulates
binding
|
FGFR1 |
0.911 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83143 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11030354 |
Crystal structure of a ternary fgf-fgfr-heparin complex reveals a dual role for heparin in fgfr binding and dimerization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Luminal Breast Cancer |
| + |
pazopanib hydrochloride | down-regulates activity 
chemical inhibition
|
FGF1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259166 |
|
|
in vitro |
|
| pmid |
sentence |
| 17620431 |
Pazopanib inhibition of a number of kinases outside of the VEGFR family was also determined. These included Abl1; Akt3; activin-like kinase 6; cyclin-dependent kinase 1/cyclin A; cyclin-dependent kinase 2/cyclin A; c-fms; c-Kit; epidermal growth factor receptor; ErbB2; ErbB4; EphB4; focal adhesion kinase; FGF receptors (FGFR) 1, 2, and 3; Flt-3; glycogen synthase kinase 3; insulin-like growth factor type I receptor; insulin receptor; interleukin-2–inducible T-cell kinase; c-jun NH2-terminal kinases 1, 2, and 3; lymphocyte-specific protein tyrosine kinase (murine); Met; p38α; PDGFRα and PDGFRβ; protein kinase C-β1 and -β2; polo-like kinases 1 and 3; Ret; Src; Syk; Tie-2; and Wee1. All assays were conducted using purified, recombinantly expressed catalytic domains of the kinases. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
FGF1 | up-regulates
binding
|
FGFR3 |
0.791 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195585 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Reports also show that fgf/fgfr3 signals mediate some of the effects of tgf-beta on embryonic bone formation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF1 | up-regulates activity
binding
|
FGFR1 |
0.911 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236936 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18940940 |
Together these data highlight the unique nature of the role of FGF-1 during the earliest stages of adipogenesis and establish a role for FGFR1 in human adipogenesis, identifying FGFR1 as a potential therapeutic target to reduce obesity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Adipose Tissue |
| Pathways: | Luminal Breast Cancer |
| + |
FGF1 | up-regulates
binding
|
FGFR2 |
0.904 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-73811 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10618369 |
We have crystallized a complex between human FGF1 and a two-domain extracellular fragment of human FGFR2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
FGF1
- 
- 