| + |
CMA1 | up-regulates activity 
cleavage
|
EDN1 |
0.485 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256356 |
Tyr83 |
TPEHVVPyGLGSPRS |
Homo sapiens |
Mast Cell |
| pmid |
sentence |
| 9257865 |
Chymase from human mast cells selectively cleaved big endothelins (ETs) at the Tyr31-Gly32 bond and produced novel trachea-constricting 31-amino acid-length endothelins, ETs(1-31), without any further degradation products. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HBB | down-regulates activity 
|
EDN1 |
0.279 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251766 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8573884 |
Hb inhibitory activity toward ET-1 production might be related to Hb mediated endothelial oxidative injury. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HBA1 | down-regulates activity
|
EDN1 |
0.264 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251767 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8573884 |
Hb inhibitory activity toward ET-1 production might be related to Hb mediated endothelial oxidative injury. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EDN1 | up-regulates quantity by expression 
transcriptional regulation
|
MYH7 |
0.284 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251955 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12847114 |
βMHC expression was markedly augmented by PE and ET, suggesting the transformation of myosin. endothelin-1 (ET) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EDN1 | up-regulates
binding
|
EDNRB |
0.946 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-145762 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16597412 |
Endothelin-1 (et-1) and angiotensin ii (angii), two potent vasoactive peptides involved in the regulation of cardiovascular homeostasis, also induce mitogenic and pro-angiogenic responses in vitro and in vivo. Both peptides are produced by cleavage of inactive precursors by metalloproteases (endothelin-converting enzyme and angiotensin-converting enzyme, respectively) and activate two subtypes of membrane receptors (eta-r and etb-r for et-1, at1r and at2r for angii) that all belong to the superfamily of g-protein coupled receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VEZF1 | up-regulates quantity by expression
transcriptional regulation
|
EDN1 |
0.281 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266884 |
|
|
Mus musculus |
Heart Endothelial Cell |
| pmid |
sentence |
| 11504723 |
Vascular endothelial zinc finger 1 (Vezf1)/DB1 is a recently identified zinc finger-containing protein that is expressed specifically within endothelial cells during development. In this report, we demonstrate that Vezf1/DB1 is a nuclear localizing protein that potently and specifically activates transcription mediated by the human endothelin-1 promoter, in a Tax-independent manner, in transient transfection assays. Regulation of endothelin-1 promoter activity by Vezf1/DB1 provides a mechanism for endothelin-1 expression in the vascular endothelium during development and to maintain vascular tone |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
UVB radiation | up-regulates
|
EDN1 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252383 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9767234 |
UVB can stimulate the synthesis of IL-1, TNF-a and ET-1, and other cytokines by keratinocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EDN1 | up-regulates quantity by expression
transcriptional regulation
|
MC1R |
0.358 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252386 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9767234 |
MSH receptor (MSH-R) binding activity was upregulated by UVB, IL-1alpha, -1beta and ET-1, but was downregulated by TNF-alpha.Northern blotanalysis showed that MC1-R mRNA expression was induced 24 h after UVB irradiation in a dose-dependent manner, and that 24-h treatment with ET-1 also induced an expression of MC1-R mRNA,whereas TNF-a downregulated the expression. In addition, IL-1a and -1b have a small but real inductiveeffect on MC1-R mRNA expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EDN1 | up-regulates
binding
|
EDNRA |
0.877 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-145759 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16597412 |
Endothelin-1 (et-1) and angiotensin ii (angii), two potent vasoactive peptides involved in the regulation of cardiovascular homeostasis, also induce mitogenic and pro-angiogenic responses in vitro and in vivo. Both peptides are produced by cleavage of inactive precursors by metalloproteases (endothelin-converting enzyme and angiotensin-converting enzyme, respectively) and activate two subtypes of membrane receptors (eta-r and etb-r for et-1, at1r and at2r for angii) that all belong to the superfamily of g-protein coupled receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
EDN1
- 
- 