Relation Results

Summary

Name KRT18
Full Name Keratin, type I cytoskeletal 18
Synonyms Cell proliferation-inducing gene 46 protein, Cytokeratin-18, CK-18, Keratin-18, K18 | CYK18
Primary ID P05783
Links - -
Type protein
Relations 6
Function Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganizati ...
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Type: Score: Layout: SPV 
0.3440.290.20.3050.3350.312CDK1KRT18CAMK2ACAMK1RPS6KA3PRKCEPRKCA

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CDK1up-regulates img/direct-activation.png phosphorylation KRT18 0.344
Identifier Residue Sequence Organism Cell Line
SIGNOR-55994 Ser34 RPVSSAAsVYAGAGG Homo sapiens
pmid sentence
We identified k18 ser33 as an interphase phosphorylation site, which increases its phosphorylation during mitosis in cultured cells and regenerating liver, and as an in vitro cdc2 kinase phosphorylation site. K18 ser33 phosphorylation dictates binding to 14_3_3 proteins
Publications: 1 Organism: Homo Sapiens
+ CAMK2A img/unknown.png phosphorylation KRT18 0.29
Identifier Residue Sequence Organism Cell Line
SIGNOR-250633 Ser53 ISVSRSTsFRGGMGS NIH-3T3 Cell
pmid sentence
Ser-52 in K18 is not glycosylated and matches consensus sequences for phosphorylation by CAM kinase, S6 kinase and protein kinase C, and all these kinases can phosphorylate K18 in vitro predominantly at that site. Expression of K18 ser-52-->ala mutant in mammalian cells showed minimal phosphorylation but no distinguishable difference in filament assembly when compared with wild-type K18. In contrast, the ser-52 mutation played a clear but nonexclusive role in filament reorganization,
Publications: 1
+ CAMK1 img/unknown.png phosphorylation KRT18 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-27398 Ser53 ISVSRSTsFRGGMGS Homo sapiens
pmid sentence
Ser-52 in k18 is not glycosylated and matches consensus sequences for phosphorylation by cam kinase..these kinases can phosphorylate k18 in vitro predominantly at that site
Publications: 1 Organism: Homo Sapiens
+ RPS6KA3 img/unknown.png phosphorylation KRT18 0.305
Identifier Residue Sequence Organism Cell Line
SIGNOR-248895 Ser53 ISVSRSTsFRGGMGS in vitro
pmid sentence
Ser-52 in K18 is not glycosylated and matches consensus sequences for phosphorylation by CAM kinase, S6 kinase and protein kinase C, and all these kinases can phosphorylate K18 in vitro predominantly at that site.
Publications: 1 Organism: In Vitro
+ PRKCE img/unknown.png phosphorylation KRT18 0.335
Identifier Residue Sequence Organism Cell Line
SIGNOR-248847 Ser53 ISVSRSTsFRGGMGS in vitro
pmid sentence
In conclusion, we have shown that the PKCe catalytic fragment physically associates with and phosphorylates CK8/18 HT29 cells. The nature of this association and its physiological significance remain to be determined.
Publications: 1 Organism: In Vitro
+ PRKCA img/unknown.png phosphorylation KRT18 0.312
Identifier Residue Sequence Organism Cell Line
SIGNOR-248894 Ser53 ISVSRSTsFRGGMGS in vitro
pmid sentence
Ser-52 in K18 is not glycosylated and matches consensus sequences for phosphorylation by CAM kinase, S6 kinase and protein kinase C, and all these kinases can phosphorylate K18 in vitro predominantly at that site.
Publications: 1 Organism: In Vitro
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