Relation Results

Summary

Name RPS6KA3
Full Name Ribosomal protein S6 kinase alpha-3
Synonyms S6K-alpha-3, 90 kDa ribosomal protein S6 kinase 3, p90-RSK 3, p90RSK3, Insulin-stimulated protein kinase 1, ISPK-1, MAP kinase-activated protein kinase 1b, MAPK-activated protein kinase 1b, MAPKAP kinase 1b, MAPKAPK-1b, Ribosomal S6 kinase 2, RSK-2, pp90RSK2 | ISPK1, MAPKAPK1B, RSK2
Primary ID P51812
Links - -
Type protein
Relations 72
Inhibitors SL0101
Function Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation ...
View More

Viewer

Type: Score: Layout: SPV 
0.5490.20.20.720.4080.20.2670.3680.2670.7220.20.6450.3660.6280.2920.3910.3490.20.4730.20.20.270.2750.20.3020.3330.390.3610.20.20.20.3750.20.360.3290.20.80.20.20.720.20.20.2RPS6KA3YBX1H3C1H3-3ACREB1ESR1CICAKT1HMGN1GSK3AMAPK3ERK1/2PDPK1PPM1DATF4HMGN2NFATC4TINF2H2BC3NR4A1FOXN2KCNK3THTRAF6PFKFB2KRT18RANBP3BADFGFR1MAP3K5VGLL1WWC1CASP8EIF2AK2SRCFYNFLT4SL0101Histone H3GbetaMAPK1MAD1L1MAD2L1CENPE

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ RPS6KA3up-regulates img/direct-activation.png phosphorylation YBX1 0.549
Identifier Residue Sequence Organism Cell Line
SIGNOR-182165 Ser102 NPRKYLRsVGDGETV Homo sapiens Breast Cancer Cell
pmid sentence
We therefore conclude that rsk1/rsk2 are novel activators of yb-1, able to phosphorylate the serine 102 residue.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA3down-regulates activity img/direct_inhibition.png phosphorylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-138475 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or uv irradiation and result in the activation of genes, such as c-fos and c-jun.
Identifier Residue Sequence Organism Cell Line
SIGNOR-70436 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or uv irradiation and result in the activation of genes, such as c-fos and c-jun.
Identifier Residue Sequence Organism Cell Line
SIGNOR-119229 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or uv irradiation and result in the activation of genes, such as c-fos and c-jun.
Publications: 3 Organism: Homo Sapiens
+ RPS6KA3down-regulates activity img/direct_inhibition.png phosphorylation H3-3A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-138471 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or uv irradiation and result in the activation of genes, such as c-fos and c-jun.
Identifier Residue Sequence Organism Cell Line
SIGNOR-70432 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or uv irradiation and result in the activation of genes, such as c-fos and c-jun.
Identifier Residue Sequence Organism Cell Line
SIGNOR-119225 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or uv irradiation and result in the activation of genes, such as c-fos and c-jun.
Publications: 3 Organism: Homo Sapiens
+ RPS6KA3up-regulates activity img/direct-activation.png phosphorylation CREB1 0.72
Identifier Residue Sequence Organism Cell Line
SIGNOR-248951 Ser119 EILSRRPsYRKILND Homo sapiens
pmid sentence
MAPK activates CREB kinase, which in turn phosphorylates and activates CREB. Purification, sequencing, and biochemical characterization of CREB kinase revealed that it is identical to a member of the pp90(RSK) family, RSK2. RSK2 was shown to mediate growth factor induction of CREB serine-133 phosphorylation both in vitro and in vivo. These findings identify a cellular function for RSK2 and define a mechanism whereby growth factor signals mediated by RAS and MAPK are transmitted to the nucleus to activate gene expression
Publications: 1 Organism: Homo Sapiens
+ RPS6KA3up-regulates img/direct-activation.png phosphorylation ESR1 0.408
Identifier Residue Sequence Organism Cell Line
SIGNOR-182958 Ser167 GGRERLAsTNDKGSM Homo sapiens Breast Cancer Cell
pmid sentence
S6k1 regulates estrogen receptor alpha (eralpha) by phosphorylating it on serine 167, leading to transcriptional activation of eralpha.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA3down-regulates img/direct_inhibition.png phosphorylation CIC 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-169887 Ser173 PGKRRTQsLSALPKE Homo sapiens Melanoma Cell
pmid sentence
Specifically, 14-3-3 binds to p90(rsk)-phosphorylated ser?_??_ Of capic?_A thereby modulating dna binding to its hmg (high-mobility group) box, whereas erk phosphorylations prevent binding of a c-terminal nls (nuclear localization sequence) to importin ?4 (kpna3)
Publications: 1 Organism: Homo Sapiens
+ AKT1down-regulates activity img/direct_inhibition.png phosphorylation RPS6KA3 0.267
Identifier Residue Sequence Organism Cell Line
SIGNOR-277548 Ser19 KMAVESPsDSAENGQ Homo sapiens MDA-MB-231 Cell
pmid sentence
Akt interacts with and phosphorylates RSK2 at S19.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA3down-regulates activity img/direct_inhibition.png phosphorylation HMGN1 0.368
Identifier Residue Sequence Organism Cell Line
SIGNOR-249100 Ser21 KEEPKRRsARLSAKP Homo sapiens HeLa Cell
pmid sentence
We report here that the NBD of the HMGN1 and -N2 protein family is highly and specifically phosphorylated during mitosis and that this phosphorylation has a major functional consequence: it abolishes the interaction of the proteins with its chromatin targets.
Identifier Residue Sequence Organism Cell Line
SIGNOR-249101 Ser25 KRRSARLsAKPPAKV Homo sapiens
pmid sentence
We report here that the NBD of the HMGN1 and -N2 protein family is highly and specifically phosphorylated during mitosis and that this phosphorylation has a major functional consequence: it abolishes the interaction of the proteins with its chromatin targets.
Publications: 2 Organism: Homo Sapiens
+ RPS6KA3down-regulates activity img/direct_inhibition.png phosphorylation GSK3A 0.267
Identifier Residue Sequence Organism Cell Line
SIGNOR-110827 Ser21 SGRARTSsFAEPGGG Homo sapiens Neutrophil
pmid sentence
P90-rsk and akt may promote rapid phosphorylation/inactivation of glycogen synthase kinase 3 in chemoattractant-stimulated neutrophils. These reactions were monitored with a phosphospecific antibody that only recognized the alpha- or beta-isoforms of GSK-3 when these proteins were phosphorylated on serine residues 21 and 9, respectively.
Publications: 1 Organism: Homo Sapiens
+ MAPK3up-regulates img/direct-activation.png phosphorylation RPS6KA3 0.722
Identifier Residue Sequence Organism Cell Line
SIGNOR-81460 Ser227 DHEKKAYsFCGTVEY Homo sapiens
pmid sentence
We have generated two monoclonal antibodies that recognize two phosphorylated sites, p-ser227 and p-thr577, in the n- and c-terminal kinase domains of rsk2, respectively. phosphorylation and activation of rsk2 by uv light involves the erk pathway
Identifier Residue Sequence Organism Cell Line
SIGNOR-81464 Thr577 AENGLLMtPCYTANF Homo sapiens
pmid sentence
We have generated two monoclonal antibodies that recognize two phosphorylated sites, p-ser227 and p-thr577, in the n- and c-terminal kinase domains of rsk2, respectively. phosphorylation and activation of rsk2 by uv light involves the erk pathway
Identifier Residue Sequence Organism Cell Line
SIGNOR-184583 Homo sapiens
pmid sentence
Erk-activates the rsk family of serine/threonine kinases,rsk1, rsk2, and rsk3.
Publications: 3 Organism: Homo Sapiens
+ ERK1/2up-regulates img/direct-activation.png phosphorylation RPS6KA3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244692 Ser227 DHEKKAYsFCGTVEY Homo sapiens
pmid sentence
We have generated two monoclonal antibodies that recognize two phosphorylated sites, p-ser227 and p-thr577, in the n- and c-terminal kinase domains of rsk2, respectively. phosphorylation and activation of rsk2 by uv light involves the erk pathway
Identifier Residue Sequence Organism Cell Line
SIGNOR-244696 Thr577 AENGLLMtPCYTANF Homo sapiens
pmid sentence
We have generated two monoclonal antibodies that recognize two phosphorylated sites, p-ser227 and p-thr577, in the n- and c-terminal kinase domains of rsk2, respectively. phosphorylation and activation of rsk2 by uv light involves the erk pathway
Identifier Residue Sequence Organism Cell Line
SIGNOR-244699 Homo sapiens
pmid sentence
Erk-activates the rsk family of serine/threonine kinases,rsk1, rsk2, and rsk3.
Publications: 3 Organism: Homo Sapiens
+ PDPK1up-regulates img/direct-activation.png phosphorylation RPS6KA3 0.645
Identifier Residue Sequence Organism Cell Line
SIGNOR-161924 Ser227 DHEKKAYsFCGTVEY Homo sapiens
pmid sentence
We characterize two monoclonal antibodies raised against phosphorylated forms of the n- and c-terminal domain of rsk2 (p-s227 and p-t577, respectively). Using these two antibodies, we show that stress signals, such as uv light, induce phosphorylation and activation of the three rsks.
Identifier Residue Sequence Organism Cell Line
SIGNOR-70612 Ser227 DHEKKAYsFCGTVEY Homo sapiens
pmid sentence
We characterize two monoclonal antibodies raised against phosphorylated forms of the n- and c-terminal domain of rsk2 (p-s227 and p-t577, respectively). Using these two antibodies, we show that stress signals, such as uv light, induce phosphorylation and activation of the three rsks.
Publications: 2 Organism: Homo Sapiens
+ PPM1Ddown-regulates activity img/direct_inhibition.png dephosphorylation RPS6KA3 0.366
Identifier Residue Sequence Organism Cell Line
SIGNOR-248320 Ser227 DHEKKAYsFCGTVEY Mus musculus
pmid sentence
RSK2 (p90 ribosomal S6 kinase 2) is activated via the ERK (extracellular-signal-regulated kinase) pathway by phosphorylation on four sites: Ser227 in the activation loop of the N-terminal kinase domain, Ser369 in the linker, Ser386 in the hydrophobic motif and Thr577 in the C-terminal kinase domain of RSK2. In the present study, we demonstrate that RSK2 is associated in vivo with PP2Cdelta (protein phosphatase 2Cdelta). In epidermal growth factorstimulated cells, RSK2 is partially dephosphorylated on all four sites in an Mn2+-dependent manner, leading to reduced protein kinase activity
Identifier Residue Sequence Organism Cell Line
SIGNOR-248321 Ser369 TAKTPKDsPGIPPSA Mus musculus
pmid sentence
RSK2 (p90 ribosomal S6 kinase 2) is activated via the ERK (extracellular-signal-regulated kinase) pathway by phosphorylation on four sites: Ser227 in the activation loop of the N-terminal kinase domain, Ser369 in the linker, Ser386 in the hydrophobic motif and Thr577 in the C-terminal kinase domain of RSK2. In the present study, we demonstrate that RSK2 is associated in vivo with PP2Cdelta (protein phosphatase 2Cdelta). In epidermal growth factorstimulated cells, RSK2 is partially dephosphorylated on all four sites in an Mn2+-dependent manner, leading to reduced protein kinase activity
Identifier Residue Sequence Organism Cell Line
SIGNOR-248322 Ser386 HQLFRGFsFVAITSD Mus musculus
pmid sentence
RSK2 (p90 ribosomal S6 kinase 2) is activated via the ERK (extracellular-signal-regulated kinase) pathway by phosphorylation on four sites: Ser227 in the activation loop of the N-terminal kinase domain, Ser369 in the linker, Ser386 in the hydrophobic motif and Thr577 in the C-terminal kinase domain of RSK2. In the present study, we demonstrate that RSK2 is associated in vivo with PP2Cdelta (protein phosphatase 2Cdelta). In epidermal growth factorstimulated cells, RSK2 is partially dephosphorylated on all four sites in an Mn2+-dependent manner, leading to reduced protein kinase activity
Identifier Residue Sequence Organism Cell Line
SIGNOR-248323 Thr577 AENGLLMtPCYTANF Mus musculus
pmid sentence
RSK2 (p90 ribosomal S6 kinase 2) is activated via the ERK (extracellular-signal-regulated kinase) pathway by phosphorylation on four sites: Ser227 in the activation loop of the N-terminal kinase domain, Ser369 in the linker, Ser386 in the hydrophobic motif and Thr577 in the C-terminal kinase domain of RSK2. In the present study, we demonstrate that RSK2 is associated in vivo with PP2Cdelta (protein phosphatase 2Cdelta). In epidermal growth factorstimulated cells, RSK2 is partially dephosphorylated on all four sites in an Mn2+-dependent manner, leading to reduced protein kinase activity
Publications: 4 Organism: Mus Musculus
+ RPS6KA3up-regulates img/direct-activation.png phosphorylation ATF4 0.628
Identifier Residue Sequence Organism Cell Line
SIGNOR-124436 Ser245 TRGSPNRsLPSPGVL Homo sapiens
pmid sentence
Here, we show that rsk2 is required for osteoblast differentiation and function. We identify the transcription factor atf4 as a critical substrate of rsk2 that is required for the timely onset of osteoblast differentiation, for terminal differentiation of osteoblasts, and for osteoblast-specific gene expression
Publications: 1 Organism: Homo Sapiens
+ RPS6KA3down-regulates activity img/direct_inhibition.png phosphorylation HMGN2 0.292
Identifier Residue Sequence Organism Cell Line
SIGNOR-249102 Ser25 KDEPQRRsARLSAKP Homo sapiens HeLa Cell
pmid sentence
We report here that the NBD of the HMGN1 and -N2 protein family is highly and specifically phosphorylated during mitosis and that this phosphorylation has a major functional consequence: it abolishes the interaction of the proteins with its chromatin targets.
Identifier Residue Sequence Organism Cell Line
SIGNOR-249103 Ser29 QRRSARLsAKPAPPK Homo sapiens HeLa Cell
pmid sentence
We report here that the NBD of the HMGN1 and -N2 protein family is highly and specifically phosphorylated during mitosis and that this phosphorylation has a major functional consequence: it abolishes the interaction of the proteins with its chromatin targets.
Publications: 2 Organism: Homo Sapiens
+ RPS6KA3up-regulates img/direct-activation.png phosphorylation NFATC4 0.391
Identifier Residue Sequence Organism Cell Line
SIGNOR-234465 Ser281 SGTPSSAsPALSRRG Mus musculus
pmid sentence
Serines 281 and 285 of the nfat3 protein might be target amino acids of rsk2 phosphorylationrsk2 induced nuclear localization of nfat3. Rsk2 phosphorylated nfat3 in vitro (km=3.559 microm), and activation of nfat3 by rsk2 enhanced the promoter activity of nfat3 downstream target genes in vivo.
Identifier Residue Sequence Organism Cell Line
SIGNOR-234469 Ser285 SSASPALsRRGSLGE Mus musculus
pmid sentence
Serines 281 and 285 of the nfat3 protein might be target amino acids of rsk2 phosphorylationrsk2 induced nuclear localization of nfat3. Rsk2 phosphorylated nfat3 in vitro (km=3.559 microm), and activation of nfat3 by rsk2 enhanced the promoter activity of nfat3 downstream target genes in vivo.
Identifier Residue Sequence Organism Cell Line
SIGNOR-234473 Ser289 PALSRRGsLGEEGSE Mus musculus
pmid sentence
The results indicated that rsk2 phosphorylated two additional sites at ser289 (peptide 2) and ser344 (peptide 3)rsk2 induced nuclear localization of nfat3. Rsk2 phosphorylated nfat3 in vitro (km=3.559 microm), and activation of nfat3 by rsk2 enhanced the promoter activity of nfat3 downstream target genes in vivo.
Identifier Residue Sequence Organism Cell Line
SIGNOR-235652 Ser344 QAVALPRsEEPASCN Mus musculus C2C12 Cell, Myoblast
pmid sentence
The results indicated that rsk2 phosphorylated two additional sites at ser289 (peptide 2) and ser344 (peptide 3)rsk2 induced nuclear localization of nfat3. Rsk2 phosphorylated nfat3 in vitro (km=3.559 microm), and activation of nfat3 by rsk2 enhanced the promoter activity of nfat3 downstream target genes in vivo.
Identifier Residue Sequence Organism Cell Line
SIGNOR-133283 Ser676 SNGRRKRsPTQSFRF Homo sapiens
pmid sentence
We demonstrate that p90 ribosomal s6 kinase (rsk) is recruited to the nfat-dna transcription complex upon activation.Bound Rsk phosphorylates ser(676) and potentiates nfatc4 dna binding. Ser(676) is also targeted by the erk map kinase.
Publications: 5 Organism: Mus Musculus, Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Myotube
+ RPS6KA3 img/unknown.png phosphorylation TINF2 0.349
Identifier Residue Sequence Organism Cell Line
SIGNOR-202532 Ser295 FPFRNLGsPTQVISK Homo sapiens
pmid sentence
Phosphorylation of serines 295 and 330 appeared to be mediated, at least in part, by the mitotic kinase rsk2. The consequence of tin2 phosphorylation during mitosis remains to be determined
Identifier Residue Sequence Organism Cell Line
SIGNOR-202536 Ser330 ASTGKSKsPCQTLGG Homo sapiens
pmid sentence
Phosphorylation of serines 295 and 330 appeared to be mediated, at least in part, by the mitotic kinase rsk2. The consequence of tin2 phosphorylation during mitosis remains to be determined
Publications: 2 Organism: Homo Sapiens
+ RPS6KA3 img/unknown.png phosphorylation H2BC3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-174026 Ser33 DGKKRKRsRKESYSI Homo sapiens
pmid sentence
Here, we studied the histone h2b core domain and found that phosphorylation of h2b serine 32 occurs in normal cycling and mitogen-stimulated cells. Notably, this phosphorylation is elevated in skin cancer cell lines and tissues compared with normal counterparts. We identified ribosomal s6 kinase 2 (rsk2) as the kinase responsible for h2bs32 phosphorylation.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA3 img/unknown.png phosphorylation NR4A1 0.473
Identifier Residue Sequence Organism Cell Line
SIGNOR-249295 Ser351 GRRGRLPsKPKQPPD Homo sapiens HEK-293 Cell
pmid sentence
In the present paper, we have re-examined the phosphorylation of Nur77 on Ser354. Using a combination of cell-permeable kinase inhibitors and mouse knockin mutations, we show that Nur77 is phosphorylated by RSK in response to mitogenic stimulation of cells. Phosphorylation of Nur77 on Ser354 did not, however, appear to affect the transcriptional activity of Nur77, or its ability to bind 14-3-3 proteins in vivo.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA3down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXN2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273840 Ser365 EDDPLGDsGYASQPC Homo sapiens NCI-H1299 Cell
pmid sentence
Importantly, we identified RSK2 kinase as the upstream kinase for the FOXN2 phosphodegron. The Ser365 and Ser369 sites in a conserved DSGYAS motif are responsible for the ubiquitination of FOXN2 by β-Trcp. 
Identifier Residue Sequence Organism Cell Line
SIGNOR-273841 Ser369 LGDSGYAsQPCAKIS Homo sapiens NCI-H1299 Cell
pmid sentence
Importantly, we identified RSK2 kinase as the upstream kinase for the FOXN2 phosphodegron. The Ser365 and Ser369 sites in a conserved DSGYAS motif are responsible for the ubiquitination of FOXN2 by β-Trcp. 
Publications: 2 Organism: Homo Sapiens
+ RPS6KA3up-regulates activity img/direct-activation.png phosphorylation KCNK3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-172470 Ser393 GLMKRRSsV Homo sapiens
pmid sentence
The chaperone protein, 14-3-3, binds to a critical phosphorylated serine in the channel c termini of k2p3.1 and k2p9.1 (ser(393) and ser(373), respectively) and overcomes retention in the endoplasmic reticulum by ?COP. We sought to identify the kinase responsible for phosphorylation of the terminal serine in human and rat variants of k2p3.1 and k2p9.1. Adopting a bioinformatic approach, three candidate protein kinases were identified: camp-dependent protein kinase, ribosomal s6 kinase, and protein kinase c.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA3up-regulates img/direct-activation.png phosphorylation TH 0.27
Identifier Residue Sequence Organism Cell Line
SIGNOR-95483 Ser40 GQGAPGPsLTGSPWP Homo sapiens
pmid sentence
Mitogen-activated protein-kinase (map) kinase-activated protein kinases 1 and 2 (mapkap kinase-1, mapkap kinase-2), were found to phosphorylate bacterially expressed human tyrosine hydroxylaserecombinant human tyrosine hydroxylase (hth1) was found to be phosphorylated by mitogen and stress-activated protein kinase 1 (msk1) at ser40 and by p38 regulated/activated kinase (prak) on ser19. Phosphorylation by msk1 induced an increase in vmax
Identifier Residue Sequence Organism Cell Line
SIGNOR-34682 Ser40 GQGAPGPsLTGSPWP Homo sapiens
pmid sentence
Mitogen-activated protein-kinase (map) kinase-activated protein kinases 1 and 2 (mapkap kinase-1, mapkap kinase-2), were found to phosphorylate bacterially expressed human tyrosine hydroxylaserecombinant human tyrosine hydroxylase (hth1) was found to be phosphorylated by mitogen and stress-activated protein kinase 1 (msk1) at ser40 and by p38 regulated/activated kinase (prak) on ser19. Phosphorylation by msk1 induced an increase in vmax
Identifier Residue Sequence Organism Cell Line
SIGNOR-34686 Ser71 RFIGRRQsLIEDARK Homo sapiens
pmid sentence
Mitogen-activated protein-kinase (map) kinase-activated protein kinases 1 and 2 (mapkap kinase-1, mapkap kinase-2), were found to phosphorylate bacterially expressed human tyrosine hydroxylaserecombinant human tyrosine hydroxylase (hth1) was found to be phosphorylated by mitogen and stress-activated protein kinase 1 (msk1) at ser40 and by p38 regulated/activated kinase (prak) on ser19. Phosphorylation by msk1 induced an increase in vmax
Identifier Residue Sequence Organism Cell Line
SIGNOR-95487 Ser71 RFIGRRQsLIEDARK Homo sapiens
pmid sentence
Mitogen-activated protein-kinase (map) kinase-activated protein kinases 1 and 2 (mapkap kinase-1, mapkap kinase-2), were found to phosphorylate bacterially expressed human tyrosine hydroxylaserecombinant human tyrosine hydroxylase (hth1) was found to be phosphorylated by mitogen and stress-activated protein kinase 1 (msk1) at ser40 and by p38 regulated/activated kinase (prak) on ser19. Phosphorylation by msk1 induced an increase in vmax
Publications: 4 Organism: Homo Sapiens
+ RPS6KA3up-regulates activity img/direct-activation.png phosphorylation TRAF6 0.275
Identifier Residue Sequence Organism Cell Line
SIGNOR-278302 Ser46 TASTGNLsSSFMEEI Homo sapiens
pmid sentence
These results demonstrate that TRAF6 K63 ubiquitination might be regulated by an RSK2 mediated phosphorylation dependent mechanism and phosphorylation of TRAF6 at Ser46, 47 and 48 enhances its ubiquitin mediated inflammation signaling.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA3up-regulates activity img/direct-activation.png phosphorylation PFKFB2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-49367 Ser466 PVRMRRNsFTPLSSS Homo sapiens
pmid sentence
Heart 6-phosphofructo-2-kinase activation by insulin results from ser-466 and ser-483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase b.
Identifier Residue Sequence Organism Cell Line
SIGNOR-23753 Ser466 PVRMRRNsFTPLSSS Homo sapiens
pmid sentence
Heart 6-phosphofructo-2-kinase activation by insulin results from ser-466 and ser-483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase b.
Publications: 2 Organism: Homo Sapiens
Tissue: Heart
+ RPS6KA3 img/unknown.png phosphorylation KRT18 0.302
Identifier Residue Sequence Organism Cell Line
SIGNOR-248895 Ser53 ISVSRSTsFRGGMGS in vitro
pmid sentence
Ser-52 in K18 is not glycosylated and matches consensus sequences for phosphorylation by CAM kinase, S6 kinase and protein kinase C, and all these kinases can phosphorylate K18 in vitro predominantly at that site.
Publications: 1 Organism: In Vitro
+ RPS6KA3up-regulates quantity img/direct-activation.png phosphorylation RANBP3 0.333
Identifier Residue Sequence Organism Cell Line
SIGNOR-276148 Ser57 HGTGHPEsAGEHALE Homo sapiens HEK-293 Cell
pmid sentence
RSK phosphorylates RanBP3 at Serine 58 residue in vitro and in vivo.RanBP3 phosphorylation increases its affinity towards Ran
Publications: 1 Organism: Homo Sapiens
+ RPS6KA3 img/unknown.png phosphorylation HMGN1 0.368
Identifier Residue Sequence Organism Cell Line
SIGNOR-249215 Ser7 sSAEGAAK Mus musculus
pmid sentence
The results presented here show that MSK2 and, to a lesser extent, MSK1 are the major protein kinases required for the phosphorylation of histone H3 at both Ser10 and Ser28 and HMG-14 at Ser6 after stimulation of primary embryonic fibroblasts by TPA or anisomycin.
Publications: 1 Organism: Mus Musculus
+ RPS6KA3down-regulates img/direct_inhibition.png phosphorylation BAD 0.39
Identifier Residue Sequence Organism Cell Line
SIGNOR-184595 Ser75 EIRSRHSsYPAGTED Homo sapiens
pmid sentence
The rsks catalyze the phosphorylation of the pro-apoptotic protein bad at serine 112 to promote cell survival.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA3down-regulates quantity img/direct_inhibition.png phosphorylation FGFR1 0.361
Identifier Residue Sequence Organism Cell Line
SIGNOR-276599 Ser789 DTRSSTCsSGEDSVF Homo sapiens U2-OS Cell
pmid sentence
 Both in vitro and in vivo experiments confirmed the interaction and we show that phosphorylated RSK2 binds to and phosphorylates serine 789 in the C-terminal tail of FGFR1.prevention of FGFR1 phosphorylation by inhibition of RSK2 activity or mutation of serine 789 to alanine reduced FGFR1 endocytosis and ubiquitination explaining mechanistically the prolonged signaling activity.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA3down-regulates activity img/direct_inhibition.png phosphorylation MAP3K5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276464 Ser83 ATRGRGSsVGGGSRR Homo sapiens HEK-293T Cell
pmid sentence
We provide evidence to show that RSK2 inhibits ASK1 by phosphorylating S83, T1109, and T1326 through a novel mechanism in which phospho-T1109/T1326 inhibits ATP binding to ASK1, while phospho-S83 attenuates ASK1 substrate MKK6 binding.
Identifier Residue Sequence Organism Cell Line
SIGNOR-276463 Thr1109 DRKIIATtLSKLKLE Homo sapiens HEK-293T Cell
pmid sentence
We provide evidence to show that RSK2 inhibits ASK1 by phosphorylating S83, T1109, and T1326 through a novel mechanism in which phospho-T1109/T1326 inhibits ATP binding to ASK1, while phospho-S83 attenuates ASK1 substrate MKK6 binding.
Identifier Residue Sequence Organism Cell Line
SIGNOR-276462 Thr1326 VNGADEDtISRFLAE Homo sapiens HEK-293T Cell
pmid sentence
We provide evidence to show that RSK2 inhibits ASK1 by phosphorylating S83, T1109, and T1326 through a novel mechanism in which phospho-T1109/T1326 inhibits ATP binding to ASK1, while phospho-S83 attenuates ASK1 substrate MKK6 binding.
Publications: 3 Organism: Homo Sapiens
+ RPS6KA3down-regulates activity img/direct_inhibition.png phosphorylation VGLL1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273842 Ser84 PNQWRYSsPWTKPQP Homo sapiens NUGC-3 Cell
pmid sentence
Site-directed mutagenesis and immunoprecipitation experiments revealed that RSK2 phosphorylated VGLL1 at S84 in the presence of TGF-β. Mutation of VGLL1 at S84 suppressed VGLL1-TEAD4 binding and the subsequent transcriptional activation of matrix metalloprotease 9 (MMP9).
Publications: 1 Organism: Homo Sapiens
+ RPS6KA3up-regulates img/direct-activation.png phosphorylation WWC1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-203302 Ser947 CRLNRSDsDSSTLSK Homo sapiens
pmid sentence
Moreover, we found that rsk1/2 specifically phosphorylates kibra at two highly conserved sites (thr(929) and ser(947)) in vitro and in cells. Rsk-mediated phosphorylation is required for kibra binding to rsk1, but not rsk2.
Identifier Residue Sequence Organism Cell Line
SIGNOR-203306 Thr929 STIIRSKtFSPGPQS Homo sapiens
pmid sentence
Moreover, we found that rsk1/2 specifically phosphorylates kibra at two highly conserved sites (thr(929) and ser(947)) in vitro and in cells. Rsk-mediated phosphorylation is required for kibra binding to rsk1, but not rsk2.
Publications: 2 Organism: Homo Sapiens
Tissue: Breast
+ RPS6KA3down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CASP8 0.375
Identifier Residue Sequence Organism Cell Line
SIGNOR-272997 Thr263 SIRDRNGtHLDAGAL
pmid sentence
The ribosomal S6 kinase 2 (RSK2) is a member of the p90 ribosomal S6 kinase (p90RSK) family of proteins and plays a critical role in proliferation, cell cycle, and cell transformation. Here, we report that RSK2 phosphorylates caspase-8, and Thr-263 was identified as a novel caspase-8 phosphorylation site. In addition, we showed that EGF induces caspase-8 ubiquitination and degradation through the proteasome pathway, and phosphorylation of Thr-263 is associated with caspase-8 stability.
Publications: 1
+ RPS6KA3up-regulates img/direct-activation.png phosphorylation EIF2AK2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-154183 Thr451 KRTRSKGtLRYMSPE Homo sapiens Skin Cancer Cell
pmid sentence
Our data indicated that phosphorylation of pkr at thr(451) is mediated through erk2 and rsk2, but not through p38 kinase.
Publications: 1 Organism: Homo Sapiens
+ SRC img/unknown.png phosphorylation RPS6KA3 0.36
Identifier Residue Sequence Organism Cell Line
SIGNOR-160056 Tyr488 DVYDDGKyVYVVTEL Homo sapiens HEK-293 Cell
pmid sentence
The results showed that tyr-488 is a major site of src but mutations at tyr-529 or tyr-707 did not significantly decrease src-dependent tyrosine phosphorylation of rsk2 (fig. 4c). However, we have previously characterized the tyr-488 site that is also phosphorylated by fgfr3 (14), and substitution of tyr-488 did not affect rsk2 activation.
Publications: 1 Organism: Homo Sapiens
+ SRCup-regulates img/direct-activation.png phosphorylation RPS6KA3 0.36
Identifier Residue Sequence Organism Cell Line
SIGNOR-160052 Tyr529 TITKTVEyLHAQGVV Homo sapiens HEK-293 Cell
pmid sentence
Together, our findings suggest that src-dependent phosphorylation at tyr-529 facilitates inactive erk binding to rsk2, which might be a general requirement for rsk2 activation by egf through the mek/erk pathway.
Publications: 1 Organism: Homo Sapiens
+ FYNup-regulates img/direct-activation.png phosphorylation RPS6KA3 0.329
Identifier Residue Sequence Organism Cell Line
SIGNOR-160048 Tyr529 TITKTVEyLHAQGVV Homo sapiens
pmid sentence
Epidermal growth factor stimulates rsk2 activation through activation of the mek/erk pathway and src-dependent tyrosine phosphorylation of rsk2 at tyr-529. By mass spectroscopy-based studies, we identified src tyrosine kinase family members src and fyn as upstream kinases of rsk2 tyr-529.
Publications: 1 Organism: Homo Sapiens
+ FLT4down-regulates img/direct_inhibition.png phosphorylation RPS6KA3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-98708 Tyr707 KGAMAATySALNRNQ Homo sapiens
pmid sentence
Upon truncation of this c-terminal stretch, or mutation of the tyr-707 residue alone, autoinhibition is attenuated, and the kinase becomes constitutively active. Based on these findings we propose that phosphorylation of the tyr-707 represents a novel alternative regulatory mechanism for p90rsk activation.
Publications: 1 Organism: Homo Sapiens
+ SL0101down-regulates img/direct_inhibition.png chemical inhibition RPS6KA3 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-207075 Homo sapiens
pmid sentence
Publications: 1 Organism: Homo Sapiens
+ RPS6KA3down-regulates activity img/direct_inhibition.png phosphorylation Histone H3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265347 Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or uv irradiation and result in the activation of genes, such as c-fos and c-jun.
Publications: 1 Organism: Homo Sapiens
+ Gbetaup-regulates img/direct-activation.png phosphorylation RPS6KA3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270014 Homo sapiens
pmid sentence
We have generated two monoclonal antibodies that recognize two phosphorylated sites, p-ser227 and p-thr577, in the n- and c-terminal kinase domains of rsk2, respectively. phosphorylation and activation of rsk2 by uv light involves the erk pathway
Publications: 1 Organism: Homo Sapiens
+ MAPK1up-regulates img/direct-activation.png phosphorylation RPS6KA3 0.72
Identifier Residue Sequence Organism Cell Line
SIGNOR-161518 Homo sapiens
pmid sentence
Erk-activates the rsk family of serine/threonine kinases,rsk1, rsk2, and rsk3.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA3up-regulates activity img/indirect-activation.png MAD1L1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252038 Homo sapiens
pmid sentence
We also show that this kinase might also participate in the maintenance of the SAC in mammalian cells as Rsk2 knockdown in these cells prevents the kinetochore localization of Mad1, Mad2 and CENP-E under checkpoint conditions.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA3up-regulates activity img/indirect-activation.png MAD2L1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252039 Homo sapiens HeLa Cell
pmid sentence
We also show that this kinase might also participate in the maintenance of the SAC in mammalian cells as Rsk2 knockdown in these cells prevents the kinetochore localization of Mad1, Mad2 and CENP-E under checkpoint conditions.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA3up-regulates activity img/indirect-activation.png CENPE 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252037 Homo sapiens HeLa Cell
pmid sentence
We also show that this kinase might also participate in the maintenance of the SAC in mammalian cells as Rsk2 knockdown in these cells prevents the kinetochore localization of Mad1, Mad2 and CENP-E under checkpoint conditions.
Publications: 1 Organism: Homo Sapiens
a simple tooltip