| + |
TNF | down-regulates quantity by repression 
transcriptional regulation
|
LPL |
0.39 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251855 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16106106 |
TNF-α and IL-6 inhibit lipoprotein lipase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251853 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 3063839 |
Cytokines, notably TNF and IL-1, suppress synthesis of lipoprotein lipase which decreases the rate of TGFA clearance. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
IL1B | down-regulates activity
|
LPL |
0.289 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251856 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1572904 |
IL-1 beta also depressed adipoconversion, inhibited markedly LPL activity, and partially reduced GPDH activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
APOA5 | up-regulates activity 
binding
|
LPL |
0.717 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251845 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21773006 |
Apo A5 binds to and enhances the activity of lipoprotein lipase (LPL) enzyme |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INS | up-regulates activity 
|
LPL |
0.463 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251858 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21966368 |
Insulin has a major effect on LPL regulation in adipose tissue since in mature adipocytes insulin not only increases the level of LPL mRNA but also regulates LPL activity through both posttranscriptional and posttranslational mechanisms |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IFNG | down-regulates quantity by repression
transcriptional regulation
|
LPL |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251854 |
|
|
Mus musculus |
J774.2 Cell |
| pmid |
sentence |
| 10909770 |
The suppression of lipoprotein lipase expression in J774.2 macrophages by IFN-gamma and TNF-alpha is mediated at the transcriptional level. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251848 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 2114181 |
Interferon-gamma inhibits lipoprotein lipase in human monocyte-derived macrophages. The data indicate that IFN-gamma is inhibiting macrophage LPL at least in part via a reduction of LPL synthesis |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| + |
CRP | up-regulates quantity by expression
transcriptional regulation
|
LPL |
0.371 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251852 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18708524 |
C-reactive protein enhances macrophage lipoprotein lipase expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
APOC3 | down-regulates activity
|
LPL |
0.644 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251850 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17315402 |
Apolipoprotein CIII inhibits the lipoprotein lipase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRL | down-regulates activity
|
LPL |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251851 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12679477 |
PRL inhibits lipoprotein lipase activity in human white adipose tissue |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | up-regulates quantity by expression
transcriptional regulation
|
LPL |
0.264 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251847 |
|
|
Mus musculus |
Macrophage |
| pmid |
sentence |
| 11742878 |
TGF-β1 inhibited gene expression and cell surface activity of LPL. TGF-β1 did not have an effect on LPL activity when it was added directly to the LPL activity assay (data not shown); however, as shown in the Table, TGF-β1 significantly reduced LPL mRNA by 55.0% |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
IFNA10 | down-regulates activity
|
LPL |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251859 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 1632769 |
Interleukin-1 and interferon-alpha and gamma induce lipolysis and decrease LPL activity but do not stimulate much PG production. These results demonstrate that cytokines enhance lipolysis and decrease LPL activity in 3T3 adipocytes by a PG independent mechanism. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PPARA | up-regulates activity
|
LPL |
0.589 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251849 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16511610 |
The effect of fibrates on the metabolism of triglyceride-rich lipoproteins is due to a PPAR-alpha-dependent stimulation of lipoprotein lipase and of apolipoprotein (apo)A-V and to an inhibition of apoC-III expression, whereas the increase in plasma HDL-cholesterol depends partly on an overexpression of apoA-I and apoA-II. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
APOC2 | up-regulates activity
|
LPL |
0.762 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251846 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19956660 |
Triglycerides in VLDL are hydrolyzed by lipoprotein lipase, which in turn is activated by apolipoprotein CII on the surface but inhibited by apolipoprotein CIII. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INS | up-regulates quantity by expression
transcriptional regulation
|
LPL |
0.463 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251857 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21966368 |
Insulin has a major effect on LPL regulation in adipose tissue since in mature adipocytes insulin not only increases the level of LPL mRNA but also regulates LPL activity through both posttranscriptional and posttranslational mechanisms |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Adipose Tissue |
3.0
LPL
- 
- 