Summary

Name APOA5
Full Name Apolipoprotein A-V
Synonyms Apo-AV, ApoA-V, Apolipoprotein A5, Regeneration-associated protein 3 | RAP3
Primary ID Q6Q788
Links - -
Type protein
Relations 3
Function Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin (PubMed:17326667).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding LPL 0.707
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation APOA5 0.288
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation APOA5 0.376
Publications: 1 Organism: Homo Sapiens