| + |
SIRT5 | up-regulates activity 
deacetylation
|
LDHB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267645 |
Lys329 |
DTLWDIQkDLKDL |
Homo sapiens |
Colorectal Cancer Cell |
| pmid |
sentence |
| 34929314 |
In colorectal cancer, SIRT5 binds to lactate dehydrogenase B (LDHB) to deacetylate it at Lysine 329, thereby increasing its enzymatic activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AURKA | up-regulates activity
phosphorylation
|
LDHB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277493 |
Ser162 |
PKHRVIGsGCNLDSA |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 31804482 |
Aurora-A-mediated phosphorylation of LDHB serine 162 significantly increases its activity in reducing pyruvate to lactate, which efficiently promotes NAD+ regeneration, glycolytic flux, lactate production and bio-synthesis with glycolytic intermediates. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LDHB | up-regulates 
|
Glycolysis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267654 |
|
|
Homo sapiens |
Burkitt Lymphoma Cell |
| pmid |
sentence |
| 34929314 |
LDHB is a glycolytic enzyme that catalyzes the conversion of lactic acid and NAD+ into pyruvate, NADH and H+. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LDHB | down-regulates quantity 
chemical modification
|
pyruvate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267656 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24929216 |
Glucose and alanine produce pyruvate which is reduced to lactate by lactate dehydrogenase in the cytoplasm without oxygen consumption. Lactate removal takes place via its oxidation to pyruvate by lactate dehydrogenase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIF-1 complex | up-regulates quantity
transcriptional regulation
|
LDHB |
0.361 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267653 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7673128 |
Deletional and mutational analysis of the function of mouse LDH-reporter fusion gene constructs in transient transfection assays defined three domains, between -41 and -84 base pairs upstream of the transcription initiation site, which were crucial for oxygen-regulated expression. The most important of these, although not capable of driving hypoxic induction in isolation, had the consensus of a hypoxia-inducible factor 1 (HIF-1) site, and cross-competed for the binding of HIF-1 with functionally active Epo and phosphoglycerate kinase-1 sequences |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LDHB | up-regulates quantity
chemical modification
|
(S)-lactate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267657 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24929216 |
Glucose and alanine produce pyruvate which is reduced to lactate by lactate dehydrogenase in the cytoplasm without oxygen consumption. Lactate removal takes place via its oxidation to pyruvate by lactate dehydrogenase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
LDHB
- 
- 