| + |
TP53 | down-regulates 
|
Glycolysis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267467 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27692180 |
P53 regulates basal expression of AIF and SCO2 and facilitates oxidative phosphorylation. The expression of GLUT1, GLUT4, and HK2 is negatively regulated by p53, whereas TIGAR expression is induced by p53. The net result of p53-mediated regulation of these glycolytic enzymes is the suppression of glycolysis. In addition, p53 directly binds and inhibits G6PD activity and downregulates the pentose phosphate pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Hexokinase | up-regulates activity 
|
Glycolysis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270310 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18350175 |
The first step in metabolism of glucose (Glc) is usually phosphorylation, catalyzed by hexokinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BRAF | up-regulates
|
Glycolysis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259373 |
|
|
Homo sapiens |
Colonic Cancer Cell Line |
| pmid |
sentence |
| 27340238 |
These alterations corresponded to mutant KRAS and BRAF-dependent increases in glucose uptake and lactate production. Metabolic reprogramming and glucose conversion to lactate in RKO cells were proportional to levels of BRAF V600E protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KRAS | up-regulates
|
Glycolysis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259372 |
|
|
Homo sapiens |
Colonic Cancer Cell Line |
| pmid |
sentence |
| 27340238 |
These alterations corresponded to mutant KRAS and BRAF-dependent increases in glucose uptake and lactate production. Metabolic reprogramming and glucose conversion to lactate in RKO cells were proportional to levels of BRAF V600E protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Hexokinase | up-regulates
|
Glycolysis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267782 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18350175 |
The first step in metabolism of glucose (Glc) is usually phosphorylation, catalyzed by hexokinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIF1A | up-regulates
|
Glycolysis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259380 |
|
|
Homo sapiens |
Synovial Fibroblast |
| pmid |
sentence |
| 28623342 |
Our results demonstrate that SF(synovial fibroblasts) are highly dependent on glycolytic metabolism and that HIF-1α plays a regulatory role in glycolysis even under aerobic conditions. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259381 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17415528 |
HIF-1 has been known as a major transcription factor for the induction of virtually all genes encoding glucose transporters and glycolytic enzymes, which allows hypoxic tumor cells to take up glucose more efficiently and metabolize pyruvate to lactate |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
LDHA | up-regulates
|
Glycolysis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259370 |
|
|
Homo sapiens |
Burkitt Lymphoma Cell |
| pmid |
sentence |
| 9192621 |
The lactate dehydrogenase-A gene (LDH-A), whose product participates in normal anaerobic glycolysis and is frequently increased in human cancers, was identified as a c-Myc-responsive gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HK2 | up-regulates activity
|
Glycolysis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259980 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18350175 |
The first step in metabolism of glucose (Glc) is usually phosphorylation, catalyzed by hexokinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FLT3 | up-regulates activity
|
Glycolysis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259982 |
|
|
Homo sapiens |
Acute Lymphoblastic Leukemia Cell Line |
| pmid |
sentence |
| 28194038 |
Here, we report that FLT3/ITD causes a significant increase in aerobic glycolysis through AKT-mediated upregulation of mitochondrial hexokinase (HK2), and renders the leukemia cells highly dependent on glycolysis and sensitive to pharmacological inhibition of glycolytic activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LDHB | up-regulates
|
Glycolysis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267654 |
|
|
Homo sapiens |
Burkitt Lymphoma Cell |
| pmid |
sentence |
| 34929314 |
LDHB is a glycolytic enzyme that catalyzes the conversion of lactic acid and NAD+ into pyruvate, NADH and H+. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMPK | up-regulates
|
Glycolysis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209929 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20640476 |
The decreased glycogen synthesis rates upon acute AMPK activation are generally coupled to an increase in the glycolytic flux, thanks to the activation of 6-phosphofructo-2-kinase (PFK-2) through direct phosphorylation on Ser466 [35]. PFK-2 catalyzes the synthesis of fructose 2,6-bisphosphate, a potent stimulator of glycolysis. Therefore, activation of AMPK rapidly mobilizes glucose into ATP-generating processes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling |
| + |
α-D-glucose | up-regulates 
|
Glycolysis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267959 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23680095 |
Glycolysis is a cytoplasmic non-oxidative reaction for glucose degradation that is composed of 9 pro cesses. A non-specific HK enzyme by using ATP phosphorylates glucose following entrance to the cell and converts it to G6P. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycogenolysis |
| + |
PFKFB2 | up-regulates
|
Glycolysis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209950 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20640476 |
The decreased glycogen synthesis rates upon acute AMPK activation are generally coupled to an increase in the glycolytic flux, thanks to the activation of 6-phosphofructo-2-kinase (PFK-2) through direct phosphorylation on Ser466 [35]. PFK-2 catalyzes the synthesis of fructose 2,6-bisphosphate, a potent stimulator of glycolysis. Therefore, activation of AMPK rapidly mobilizes glucose into ATP-generating processes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling |
3.0
Glycolysis