Relation Results

Summary

Name TUBB
Full Name Tubulin beta chain
Synonyms Tubulin beta-5 chain | TUBB5
Primary ID P07437
Links - -
Type protein
Relations 11
Inhibitors Vincristine sulfate; vincaleukoblastine sulfate; vinorelbine L-tartrate
Function Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeab ...
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Type: Score: Layout: SPV 
0.80.20.20.20.20.3880.80.80.2Vincristine sulfateTUBBYAP/TAZJAKMIP1SMAD3YAP1NUMA1vincaleukoblastine sulfatevinorelbine L-tartrateSMAD2

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Relations
Regulator
Mechanism
target
score ℹ
+ Vincristine sulfatedown-regulates activity img/direct_inhibition.png chemical inhibition TUBB 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-259251 Homo sapiens
pmid sentence
Vincristine is commonly administered as an effective anti-brain tumor drug. Vincristine treatment also impaired the microtubule-associated protein tubulin, and fibronectin, and downregulated MMP10 activity.
Publications: 1 Organism: Homo Sapiens
+ YAP/TAZup-regulates quantity by expression img/indirect-activation.png transcriptional regulation TUBB 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276583
pmid sentence
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ.
Publications: 1
+ JAKMIP1up-regulates quantity by stabilization img/direct-activation.png binding TUBB 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260987 Homo sapiens JURKAT Cell
pmid sentence
In Jamip1, the N-terminal region mediates the association with microtubules, when highly expressed, N-ter drastically affects the organization of microtubules that appear to be bundled, stabilized against the depolymerizing effect of nocodazole, and enriched in acetylated tubulin.
Publications: 1 Organism: Homo Sapiens
+ TUBBdown-regulates activity img/direct_inhibition.png binding SMAD3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-232113 Homo sapiens
pmid sentence
Smad2/3 also binds to _-tubulin, which provides a negative regulatory mechanism controlling tgf-_ activity. the results showed that the mh2 domain of smad2 binds to _-tubulin with almost the same efficiency as the full-length (wild-type) smad2. Similar results were obtained for the smad3 binding to _-tubulin.
Publications: 1 Organism: Homo Sapiens
+ YAP1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TUBB 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276571
pmid sentence
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ.
Publications: 1
Tissue: MCF-10A Cell
+ NUMA1up-regulates img/direct-activation.png binding TUBB 0.388
Identifier Residue Sequence Organism Cell Line
SIGNOR-116900 Homo sapiens
pmid sentence
Direct binding of numa to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules.
Publications: 1 Organism: Homo Sapiens
+ TUBBdown-regulates img/direct_inhibition.png binding SMAD3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-154319 Homo sapiens
pmid sentence
Smad2/3 also binds to _-tubulin, which provides a negative regulatory mechanism controlling tgf-_ activity. the results showed that the mh2 domain of smad2 binds to _-tubulin with almost the same efficiency as the full-length (wild-type) smad2. Similar results were obtained for the smad3 binding to _-tubulin.
Publications: 1 Organism: Homo Sapiens
+ vincaleukoblastine sulfatedown-regulates activity img/direct_inhibition.png chemical inhibition TUBB 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-259256 Homo sapiens
pmid sentence
Tubulin binding molecules have generated considerable interest after the successful introduction of the taxanes into clinical oncology and the widespread use of the vinca alkaloids vincristine and vinblastine. These compounds inhibit cell mitosis by binding to the protein tubulin in the mitotic spindle and preventing polymerization into the MTs.
Publications: 1 Organism: Homo Sapiens
+ vinorelbine L-tartratedown-regulates activity img/direct_inhibition.png chemical inhibition TUBB 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-259348 Homo sapiens
pmid sentence
Vinorelbine (Navelbine; Burroughs Wellcome Co, Research Triangle Park, NC; Pierre Fabre Médicament, Paris, France) and paclitaxel (Taxol; Bristol-Myers Oncology, Princeton, NJ) as single-agent therapy exhibit good activity in breast and lung cancers. Because these agents bind to distinct sites on tubulin and affect microtubules in opposite ways, a pilot study was conducted of the combination of vinorelbine and paclitaxel in patients with metastatic breast cancer or lung cancer who were refractory to first-line chemotherapy.
Publications: 1 Organism: Homo Sapiens
+ TUBBdown-regulates img/direct_inhibition.png binding SMAD2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-154316 Homo sapiens
pmid sentence
Smad2/3 also binds to _-tubulin, which provides a negative regulatory mechanism controlling tgf-_ activity. the results showed that the mh2 domain of smad2 binds to _-tubulin with almost the same efficiency as the full-length (wild-type) smad2. Similar results were obtained for the smad3 binding to _-tubulin.
Publications: 1 Organism: Homo Sapiens
+ TUBBdown-regulates activity img/direct_inhibition.png binding SMAD2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-217631 Homo sapiens
pmid sentence
Smad2/3 also binds to _-tubulin, which provides a negative regulatory mechanism controlling tgf-_ activity. the results showed that the mh2 domain of smad2 binds to _-tubulin with almost the same efficiency as the full-length (wild-type) smad2. Similar results were obtained for the smad3 binding to _-tubulin.
Publications: 1 Organism: Homo Sapiens
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