| + |
TUBB | down-regulates activity 
binding
|
SMAD3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-232113 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17429065 |
Smad2/3 also binds to _-tubulin, which provides a negative regulatory mechanism controlling tgf-_ activity. the results showed that the mh2 domain of smad2 binds to _-tubulin with almost the same efficiency as the full-length (wild-type) smad2. Similar results were obtained for the smad3 binding to _-tubulin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NUMA1 | up-regulates 
binding
|
TUBB |
0.377 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116900 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11956313 |
Direct binding of numa to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TUBB | down-regulates activity
binding
|
SMAD2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217631 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17429065 |
Smad2/3 also binds to _-tubulin, which provides a negative regulatory mechanism controlling tgf-_ activity. the results showed that the mh2 domain of smad2 binds to _-tubulin with almost the same efficiency as the full-length (wild-type) smad2. Similar results were obtained for the smad3 binding to _-tubulin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAKMIP1 | up-regulates quantity by stabilization
binding
|
TUBB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260987 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 15277531 |
In Jamip1, the N-terminal region mediates the association with microtubules, when highly expressed, N-ter drastically affects the organization of microtubules that appear to be bundled, stabilized against the depolymerizing effect of nocodazole, and enriched in acetylated tubulin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
vinorelbine L-tartrate | down-regulates activity
chemical inhibition
|
TUBB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259348 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7740336 |
Vinorelbine (Navelbine; Burroughs Wellcome Co, Research Triangle Park, NC; Pierre Fabre Médicament, Paris, France) and paclitaxel (Taxol; Bristol-Myers Oncology, Princeton, NJ) as single-agent therapy exhibit good activity in breast and lung cancers. Because these agents bind to distinct sites on tubulin and affect microtubules in opposite ways, a pilot study was conducted of the combination of vinorelbine and paclitaxel in patients with metastatic breast cancer or lung cancer who were refractory to first-line chemotherapy. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP1 | up-regulates quantity by expression 
transcriptional regulation
|
TUBB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276571 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ. |
|
| Publications: |
1 |
| Tissue: |
MCF-10A Cell |
| + |
TUBB | down-regulates
binding
|
SMAD3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154319 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17429065 |
Smad2/3 also binds to _-tubulin, which provides a negative regulatory mechanism controlling tgf-_ activity. the results showed that the mh2 domain of smad2 binds to _-tubulin with almost the same efficiency as the full-length (wild-type) smad2. Similar results were obtained for the smad3 binding to _-tubulin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Vincristine sulfate | down-regulates activity
chemical inhibition
|
TUBB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259251 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30599272 |
Vincristine is commonly administered as an effective anti-brain tumor drug. Vincristine treatment also impaired the microtubule-associated protein tubulin, and fibronectin, and downregulated MMP10 activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP/TAZ | up-regulates quantity by expression
transcriptional regulation
|
TUBB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276583 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ. |
|
| Publications: |
1 |
| + |
vincaleukoblastine sulfate | down-regulates activity
chemical inhibition
|
TUBB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259256 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15579115 |
Tubulin binding molecules have generated considerable interest after the successful introduction of the taxanes into clinical oncology and the widespread use of the vinca alkaloids vincristine and vinblastine. These compounds inhibit cell mitosis by binding to the protein tubulin in the mitotic spindle and preventing polymerization into the MTs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TUBB | down-regulates
binding
|
SMAD2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154316 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17429065 |
Smad2/3 also binds to _-tubulin, which provides a negative regulatory mechanism controlling tgf-_ activity. the results showed that the mh2 domain of smad2 binds to _-tubulin with almost the same efficiency as the full-length (wild-type) smad2. Similar results were obtained for the smad3 binding to _-tubulin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TUBB
- 
- 