| + |
YAP/TAZ | up-regulates activity 
binding
|
RUNX2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277672 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25287865 |
The WW domains are essential for YAP-induced cell proliferation (261) and mediate binding of YAP/TAZ to PPxY motif-containing transcription factors such as RUNX, p73, and the cytoplasmic domain of ERBB4 or with the transcriptional cofactor WBP2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277667 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25287865 |
The WW domains are essential for YAP-induced cell proliferation (261) and mediate binding of YAP/TAZ to PPxY motif-containing transcription factors such as RUNX, p73, and the cytoplasmic domain of ERBB4 or with the transcriptional cofactor WBP2 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
YAP/TAZ | up-regulates activity
binding
|
ERBB4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277671 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25287865 |
The WW domains are essential for YAP-induced cell proliferation (261) and mediate binding of YAP/TAZ to PPxY motif-containing transcription factors such as RUNX, p73, and the cytoplasmic domain of ERBB4 or with the transcriptional cofactor WBP2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277666 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25287865 |
The WW domains are essential for YAP-induced cell proliferation (261) and mediate binding of YAP/TAZ to PPxY motif-containing transcription factors such as RUNX, p73, and the cytoplasmic domain of ERBB4 or with the transcriptional cofactor WBP2 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
YAP/TAZ | up-regulates activity
binding
|
SMAD3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277662 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25287865 |
YAP and TAZ were repeatedly isolated as binding proteins for Smads, key transducer of the TGF- and BMP signaling pathways (2, 207, 208). Cytoplasmic YAP/TAZ participate in Smad2/3 cytoplasmic retention, even overruling the ef- fects of high levels of TGF- ligands |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP/TAZ | up-regulates quantity by expression 
transcriptional regulation
|
MCM3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276580 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ. |
|
| Publications: |
1 |
| + |
YAP/TAZ | up-regulates activity
binding
|
SMAD2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277661 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25287865 |
YAP and TAZ were repeatedly isolated as binding proteins for Smads, key transducer of the TGF- and BMP signaling pathways (2, 207, 208). Cytoplasmic YAP/TAZ participate in Smad2/3 cytoplasmic retention, even overruling the ef- fects of high levels of TGF- ligands |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP/TAZ | up-regulates activity
relocalization
|
BRD4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276574 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
BRD4 is recruited to chromatin by YAP/TAZ |
|
| Publications: |
1 |
| + |
CTNNB1 | down-regulates activity 
binding
|
YAP/TAZ |
0.547 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277656 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24976009 |
YAP/TAZ Are Transcriptionally Inactivated by Sequestration in the Destruction Complex. YAP and TAZ Are Sequestered in the Cytoplasm by the β-Catenin Destruction Complex. This analysis revealed that Axin1 not only bound established elements of the destruction complex (such as GSK3β, β-catenin and β-TrCP) but, remarkably, also strongly associated to endogenous YAP and TAZ (Figure 1A). To further confirm YAP/TAZ association to the destruction complex, we carried out immunoprecipitations for endogenous YAP/TAZ from extracts of control or Axin1/2-depleted HEK293 cells. As shown in Figure 1B, YAP and TAZ associate with endogenous Axin1, β-catenin, GSK3, and β-TrCP. mplex |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP/TAZ | up-regulates activity
binding
|
RUNX1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277664 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25287865 |
The WW domains are essential for YAP-induced cell proliferation (261) and mediate binding of YAP/TAZ to PPxY motif-containing transcription factors such as RUNX, p73, and the cytoplasmic domain of ERBB4 or with the transcriptional cofactor WBP2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277669 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25287865 |
The WW domains are essential for YAP-induced cell proliferation (261) and mediate binding of YAP/TAZ to PPxY motif-containing transcription factors such as RUNX, p73, and the cytoplasmic domain of ERBB4 or with the transcriptional cofactor WBP2 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
YAP/TAZ | up-regulates activity
binding
|
TP73 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277668 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25287865 |
The WW domains are essential for YAP-induced cell proliferation (261) and mediate binding of YAP/TAZ to PPxY motif-containing transcription factors such as RUNX, p73, and the cytoplasmic domain of ERBB4 or with the transcriptional cofactor WBP2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277663 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25287865 |
The WW domains are essential for YAP-induced cell proliferation (261) and mediate binding of YAP/TAZ to PPxY motif-containing transcription factors such as RUNX, p73, and the cytoplasmic domain of ERBB4 or with the transcriptional cofactor WBP2 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
YAP/TAZ | up-regulates quantity by expression
transcriptional regulation
|
TUBB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276583 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ. |
|
| Publications: |
1 |
| + |
YAP/TAZ | up-regulates activity
binding
|
WBP2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277665 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25287865 |
The WW domains are essential for YAP-induced cell proliferation (261) and mediate binding of YAP/TAZ to PPxY motif-containing transcription factors such as RUNX, p73, and the cytoplasmic domain of ERBB4 or with the transcriptional cofactor WBP2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277670 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25287865 |
The WW domains are essential for YAP-induced cell proliferation (261) and mediate binding of YAP/TAZ to PPxY motif-containing transcription factors such as RUNX, p73, and the cytoplasmic domain of ERBB4 or with the transcriptional cofactor WBP2 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
WWTR1 | up-regulates
|
YAP/TAZ |
0.53 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276573 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
The transcription coactivators YAP/TAZ are ideal candidates to mediate cancer-specific transcriptional addictions. In fact, YAP/TAZ are genetically dispensable for homeostasis in many adult tissues9–17 while YAP/TAZ activation is a hallmark of many human malignancies13,17–19. Here we show that tumor transcriptional dependencies in fact overlap with tumor reliance on YAP/TAZ. |
|
| Publications: |
1 |
| + |
YAP/TAZ | down-regulates 
|
Apoptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277639 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23075495 |
YAP and TAZ are two main downstream effectors of the Hippo pathway, and they function as transcription co-activators to promote cell proliferation and inhibit apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP/TAZ | up-regulates activity
binding
|
TEAD |
0.94 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277635 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
YAP/TAZ do not contain intrinsic DNA-binding domains but instead bind to the promoters of target genes by interacting with DNA-binding transcription factors. YAP/TAZ mainly bind to the transcription factors TEAD1–4 to regulate genes involved in cell proliferation and cell death |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP/TAZ | up-regulates quantity by expression
transcriptional regulation
|
CDC6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276576 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ. |
|
| Publications: |
1 |
| + |
YAP/TAZ | up-regulates quantity by expression
transcriptional regulation
|
KIF23 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276579 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ. |
|
| Publications: |
1 |
| + |
YAP/TAZ | up-regulates quantity by expression
transcriptional regulation
|
CCNA2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276575 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ. |
|
| Publications: |
1 |
| + |
YAP/TAZ | up-regulates
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277640 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23075495 |
YAP and TAZ are two main downstream effectors of the Hippo pathway, and they function as transcription co-activators to promote cell proliferation and inhibit apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMOT | down-regulates activity
binding
|
YAP/TAZ |
0.728 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277657 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21205866 |
AMOT inhibits YAP/TAZ by regulating YAP/TAZ localization via physical interaction and promoting YAP/TAZ phosphorylation by the Hippo pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP/TAZ | up-regulates quantity by expression
transcriptional regulation
|
TOP2A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276582 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ. |
|
| Publications: |
1 |
| + |
YAP/TAZ | up-regulates quantity by expression
transcriptional regulation
|
RRM2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276581 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ. |
|
| Publications: |
1 |
| + |
YAP/TAZ | up-regulates quantity by expression
transcriptional regulation
|
GINS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276578 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ. |
|
| Publications: |
1 |
| + |
SCF-betaTRCP | down-regulates quantity by destabilization
ubiquitination
|
YAP/TAZ |
0.391 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277637 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Phosphorylation of YAP (S381) and TAZ (S311) by Lats1/2 primes subsequent phosphorylation events by casein kinase 1 (CK1d/e); this sequential phosphorylation results in recruitment of b-transducin repeat-containing proteins (b-TRCP; a subunit of the SCF ubiquitin E3 ligase) and consequently leads to degradation of YAP/TAZ |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP/TAZ | up-regulates quantity by expression
transcriptional regulation
|
CDCA5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276577 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ. |
|
| Publications: |
1 |
| + |
YAP/TAZ | down-regulates activity
binding
|
DDX17 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277659 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26045258 |
In addition, nuclear YAP has also been found to regulate miRNA processing. Nuclear YAP/TAZ bind and sequester DEAD box helicase 17 (DDX17) (also known as p72) to repress its association with Microprocessor, a complex that regulates miRNA processing (Figure 3B). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP1 | up-regulates
|
YAP/TAZ |
0.53 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276572 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
The transcription coactivators YAP/TAZ are ideal candidates to mediate cancer-specific transcriptional addictions. In fact, YAP/TAZ are genetically dispensable for homeostasis in many adult tissues9–17 while YAP/TAZ activation is a hallmark of many human malignancies13,17–19. Here we show that tumor transcriptional dependencies in fact overlap with tumor reliance on YAP/TAZ. |
|
| Publications: |
1 |
3.0
YAP/TAZ