Summary

Name CTSL
Full Name Procathepsin L
Synonyms Cathepsin L, Major excreted protein, MEP | CTSL1
Primary ID P07711
Links - -
Type protein
Relations 6
Pathways COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY
Inhibitors aloxistatin
Function Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (By similarity). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells. Also mediates invariant chain processing in cortical thymic epithelial cells (By similarity). Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (By similarity). Secreted form generates endostatin from COL18A1 (PubMed:10716919). Critical for cardiac morphology and function. Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (By similarity). Required for maximal stimulation of steroidogenesis by TIMP1 (By similarity).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ CTSLdown-regulates quantity by destabilization img/direct_inhibition.png cleavage BGLAP 0.2
Publications: 2 Organism: In Vitro
+ CTSLup-regulates activity img/direct-activation.png cleavage S 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY
+ CTSLup-regulates activity img/direct-activation.png cleavage S 0.2
Publications: 1 Organism: In Vitro
Pathways:COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY
+ NSFL1Cdown-regulates activity img/direct_inhibition.png binding CTSL 0.2
Publications: 1 Organism: In Vitro
+ aloxistatindown-regulates activity img/direct_inhibition.png chemical inhibition CTSL 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY