Relation Results

Summary

Name BGLAP
Full Name Osteocalcin
Synonyms Bone Gla protein, BGP, Gamma-carboxyglutamic acid-containing protein
Primary ID P02818
Links - -
Type protein
Relations 16
Pathways Vitamin-K cycle
Function Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

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Type: Score: Layout: SPV 
0.3190.20.2870.3360.3140.6740.5030.20.4330.5930.20.378CTSDBGLAPCTSLCTSHCTSBCTSSGGCXSP7ETS2RUNX2/EP300RUNX2SMOC1TGFB1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CTSDdown-regulates quantity by destabilization img/direct_inhibition.png cleavage BGLAP 0.319
Identifier Residue Sequence Organism Cell Line
SIGNOR-256319 Ala92 DHIGFQEaYRRFYGP in vitro
pmid sentence
This study has been undertaken to compare the degradation of BGP by the cysteine proteinases cathepsins L, B, H, S, and the aspartic proteinase cathepsin D. Cathepsins B, L, H, and S readily cleave BGP at the G7-A8 bond; cathepsin L also cleaves at R43-R44; cathepsin B also cleaves at R44-F45; and cathepsin D cleaves only at A41-Y42.
Publications: 1 Organism: In Vitro
+ CTSLdown-regulates quantity by destabilization img/direct_inhibition.png cleavage BGLAP 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-256322 Arg94 IGFQEAYrRFYGPV in vitro
pmid sentence
This study has been undertaken to compare the degradation of BGP by the cysteine proteinases cathepsins L, B, H, S, and the aspartic proteinase cathepsin D. Cathepsins B, L, H, and S readily cleave BGP at the G7-A8 bond; cathepsin L also cleaves at R43-R44; cathepsin B also cleaves at R44-F45; and cathepsin D cleaves only at A41-Y42.
Identifier Residue Sequence Organism Cell Line
SIGNOR-256321 Gly58 RYLYQWLgAPVPYPD in vitro
pmid sentence
This study has been undertaken to compare the degradation of BGP by the cysteine proteinases cathepsins L, B, H, S, and the aspartic proteinase cathepsin D. Cathepsins B, L, H, and S readily cleave BGP at the G7-A8 bond; cathepsin L also cleaves at R43-R44; cathepsin B also cleaves at R44-F45; and cathepsin D cleaves only at A41-Y42.
Publications: 2 Organism: In Vitro
+ CTSHdown-regulates quantity by destabilization img/direct_inhibition.png cleavage BGLAP 0.287
Identifier Residue Sequence Organism Cell Line
SIGNOR-256325 Arg94 IGFQEAYrRFYGPV in vitro
pmid sentence
This study has been undertaken to compare the degradation of BGP by the cysteine proteinases cathepsins L, B, H, S, and the aspartic proteinase cathepsin D. Cathepsins B, L, H, and S readily cleave BGP at the G7-A8 bond; cathepsin L also cleaves at R43-R44; cathepsin B also cleaves at R44-F45; and cathepsin D cleaves only at A41-Y42.
Identifier Residue Sequence Organism Cell Line
SIGNOR-256324 Gly58 RYLYQWLgAPVPYPD in vitro
pmid sentence
This study has been undertaken to compare the degradation of BGP by the cysteine proteinases cathepsins L, B, H, S, and the aspartic proteinase cathepsin D. Cathepsins B, L, H, and S readily cleave BGP at the G7-A8 bond; cathepsin L also cleaves at R43-R44; cathepsin B also cleaves at R44-F45; and cathepsin D cleaves only at A41-Y42.
Publications: 2 Organism: In Vitro
+ CTSBdown-regulates quantity by destabilization img/direct_inhibition.png cleavage BGLAP 0.336
Identifier Residue Sequence Organism Cell Line
SIGNOR-256320 Arg95 GFQEAYRrFYGPV in vitro
pmid sentence
This study has been undertaken to compare the degradation of BGP by the cysteine proteinases cathepsins L, B, H, S, and the aspartic proteinase cathepsin D. Cathepsins B, L, H, and S readily cleave BGP at the G7-A8 bond; cathepsin L also cleaves at R43-R44; cathepsin B also cleaves at R44-F45; and cathepsin D cleaves only at A41-Y42.
Identifier Residue Sequence Organism Cell Line
SIGNOR-256318 Gly58 RYLYQWLgAPVPYPD in vitro
pmid sentence
This study has been undertaken to compare the degradation of BGP by the cysteine proteinases cathepsins L, B, H, S, and the aspartic proteinase cathepsin D. Cathepsins B, L, H, and S readily cleave BGP at the G7-A8 bond; cathepsin L also cleaves at R43-R44; cathepsin B also cleaves at R44-F45; and cathepsin D cleaves only at A41-Y42.
Publications: 2 Organism: In Vitro
+ CTSSdown-regulates quantity by destabilization img/direct_inhibition.png cleavage BGLAP 0.314
Identifier Residue Sequence Organism Cell Line
SIGNOR-256323 Gly58 RYLYQWLgAPVPYPD in vitro
pmid sentence
This study has been undertaken to compare the degradation of BGP by the cysteine proteinases cathepsins L, B, H, S, and the aspartic proteinase cathepsin D. Cathepsins B, L, H, and S readily cleave BGP at the G7-A8 bond; cathepsin L also cleaves at R43-R44; cathepsin B also cleaves at R44-F45; and cathepsin D cleaves only at A41-Y42.
Publications: 1 Organism: In Vitro
+ GGCXup-regulates activity img/direct-activation.png carboxylation BGLAP 0.674
Identifier Residue Sequence Organism Cell Line
SIGNOR-265922 Homo sapiens
pmid sentence
Thus, vitamin K acts as a cofactor for GGCX via the vitamin K cycle and exerts physiological effects through its regulation of VKDPs [29]. More than 20 VKDPs have been found. Osteocalcin promotes bone formation, and blood coagulation factors II, VII, IX, and X activate blood coagulation. Matrix Gla protein suppresses cardiovascular calcification, and brain-expressed Gas 6 promotes neural differentiation [29]. GGCX is an enzyme that converts glutamic acid (Glu) residues to Gla residues, so that the Gla-containing proteins can exert various physiological actions such as blood coagulation and bone formation.
Publications: 1 Organism: Homo Sapiens
Pathways:Vitamin-K cycle
+ SP7up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BGLAP 0.503
Identifier Residue Sequence Organism Cell Line
SIGNOR-255409 Mus musculus C3H10T1/2 Cell, C2C12 Cell
pmid sentence
To test whether Osx could activate typical osteoblast genes, we transfected an Osx expressing vector into both C2C12 and C3H10T1/2 cells. Our results showed that Osx produced an induction of osteocalcin RNA in both cell types.
Publications: 1 Organism: Mus Musculus
+ ETS2up-regulates quantity by expression img/direct-activation.png transcriptional regulation BGLAP 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-259875 Mus musculus
pmid sentence
Ets2 is expressed at high levels during the differentiation and matrix mineralization phases of MC3T3-E1 culture. In addition, several extracellular matrix (ECM) associated gene products are targets of Ets2. Some of these matrix associated genes include: bone sialoprotein, osteonectin, osteocalcin and osteopontin
Publications: 1 Organism: Mus Musculus
+ RUNX2/EP300up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BGLAP 0.433
Identifier Residue Sequence Organism Cell Line
SIGNOR-255420 Rattus norvegicus ROS-17/2.8 Cell
pmid sentence
In agreement with our studies in ROS 17/2.8 cells, coexpression of p300 and Runx2/Cbfa1 resulted in marked enhancement of the OC promoter activity, further indicating that both factors cooperate to stimulate this promoter.
Publications: 1 Organism: Rattus Norvegicus
+ RUNX2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BGLAP 0.593
Identifier Residue Sequence Organism Cell Line
SIGNOR-255408 Mus musculus F9-12 Cell, ROS-17/2.8 Cell
pmid sentence
Indeed, we identified Osf2/Cbfa1 binding sites in the promoter of four genes expressed only (the Osteocalcin genes) or highly (α1(I) collagen, Bsp, and Osteopontin) in osteoblasts. Each of these elements was able to bind Osf2/Cbfa1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-107160 Homo sapiens
pmid sentence
Tgf-beta inhibited the expression of the cbfa1 and osteocalcin genes, whose expression is controlled by cbfa1 in osteoblast-like cell lines. This inhibition was mediated by smad3, which interacts physically with cbfa1 and represses its transcriptional activity at the cbfa1-binding ose2 promoter sequence
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ SMOC1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BGLAP 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260400 Homo sapiens
pmid sentence
The expression of several osteoblast differentiation markers (ALP, COL1, OPN, ON, BSP and OC) was higher in SMOC1-overexpressing cells than in emptyvector-expressing cells
Publications: 1 Organism: Homo Sapiens
+ TGFB1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BGLAP 0.378
Identifier Residue Sequence Organism Cell Line
SIGNOR-107248 Homo sapiens
pmid sentence
Tgf-beta inhibited the expression of the cbfa1 and_ osteocalcin_ genes.
Publications: 1 Organism: Homo Sapiens
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