4.0
Summary
| Name |  CTSBView Modifications |
| Full Name | Cathepsin B |
| Synonyms | APP secretase, APPS, Cathepsin B1 | CPSB |
| Primary ID | P07858 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Pathways | COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY |
| Inhibitors | aloxistatin |
| Function | Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (PubMed:3972105). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CTSB | down-regulates quantity by destabilization 
cleavage
|
BGLAP | 0.329 |
| Publications: | 2 | Organism: | In Vitro | |
| + | aloxistatin | down-regulates activity
chemical inhibition
|
CTSB | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY | |||
| + | CTSB | up-regulates activity 
cleavage
|
S | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY | |||