| + |
VHL | up-regulates quantity by expression 
transcriptional regulation
|
SPARC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255603 |
|
|
Homo sapiens |
Renal Cell Carcinoma Cell |
| pmid |
sentence |
| 15824735 |
three of the nine targets had been identified previously as candidate TSGs (DOC-2/DAB2, CDKN1C and SPARC) and all were upregulated by wild-type pVHL. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETS2 | up-regulates quantity by expression 
transcriptional regulation
|
SPARC |
0.306 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259874 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11175361 |
Ets2 is expressed at high levels during the differentiation and matrix mineralization phases of MC3T3-E1 culture. In addition, several extracellular matrix (ECM) associated gene products are targets of Ets2. Some of these matrix associated genes include: bone sialoprotein, osteonectin, osteocalcin and osteopontin |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SMOC1 | up-regulates quantity by expression
transcriptional regulation
|
SPARC |
0.402 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260401 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20359165 |
The expression of several osteoblast differentiation markers (ALP, COL1, OPN, ON, BSP and OC) was higher in SMOC1-overexpressing cells than in emptyvector-expressing cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SATB1 | up-regulates quantity by expression
transcriptional regulation
|
SPARC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255128 |
|
|
Homo sapiens |
K-562 Cell |
| pmid |
sentence |
| 17343824 |
In this study, a SATB1 eukaryotic expression plasmid was transfected into the human erythroleukemia K562 cell line and individual clones that stably over-expressed the SATB1 protein were isolated. Microarray analysis revealed that hundreds of genes were either up- or down-regulated in the SATB1 over-expressing K562 cell lines. One of these was the extra-cellular matrix glycoprotein, SPARC (human secreted protein acidic and rich in cysteine). siRNA knock-down of SATB1 also reduced SPARC expression, which was consistent with elevated SPARC levels in the SATB1 over-expressing cell line. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
SPARC
- 
- 