Summary

Name SPARC
Full Name SPARC
Synonyms Basement-membrane protein 40, BM-40, Osteonectin, ON, Secreted protein acidic and rich in cysteine | ON
Primary ID P09486
Links - -
Type protein
Relations 4
Function Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.

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Relations

Regulator Mechanism target score ℹ
+ ETS2up-regulates quantity by expression img/direct-activation.png transcriptional regulation SPARC 0.311
Publications: 1 Organism: Mus Musculus
+ SATB1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SPARC 0.2
Publications: 1 Organism: Homo Sapiens
+ SMOC1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SPARC 0.411
Publications: 1 Organism: Homo Sapiens
+ VHLup-regulates quantity by expression img/indirect-activation.png transcriptional regulation SPARC 0.2
Publications: 1 Organism: Homo Sapiens