| + |
CDK10 | down-regulates quantity by destabilization 
phosphorylation
|
ETS2 |
0.544 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260913 |
Ser220 |
PKGGLLDsMCPASTP |
Homo sapiens |
|
| pmid |
sentence |
| 24218572 |
Altogether, these results suggest that CDK10/cyclin M directly controls ETS2 degradation through the phosphorylation of these two serines. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260914 |
Ser225 |
LDSMCPAsTPSVLSS |
Homo sapiens |
|
| pmid |
sentence |
| 24218572 |
Altogether, these results suggest that CDK10/cyclin M directly controls ETS2 degradation through the phosphorylation of these two serines. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CAMK2A | down-regulates
phosphorylation
|
ETS2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183596 |
Ser246 |
FPKSRLSsVSVTYCS |
Homo sapiens |
|
| pmid |
sentence |
| 19182667 |
Camkii caused ets-2 phosphorylation.Serine 246, 310, and 313 were the targets. Camkii to phosphorylates ets-2, thus altering ets-2 binding to its downstream promoters |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183600 |
Ser310 |
LDVQRVPsFESFEDD |
Homo sapiens |
|
| pmid |
sentence |
| 19182667 |
Camkii caused ets-2 phosphorylation.Serine 246, 310, and 313 were the targets. Camkii to phosphorylates ets-2, thus altering ets-2 binding to its downstream promoters |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183604 |
Ser313 |
QRVPSFEsFEDDCSQ |
Homo sapiens |
|
| pmid |
sentence |
| 19182667 |
Camkii caused ets-2 phosphorylation.Serine 246, 310, and 313 were the targets. Camkii to phosphorylates ets-2, thus altering ets-2 binding to its downstream promoters |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
ETS2 | up-regulates quantity by expression 
transcriptional regulation
|
SPARC |
0.311 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259874 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11175361 |
Ets2 is expressed at high levels during the differentiation and matrix mineralization phases of MC3T3-E1 culture. In addition, several extracellular matrix (ECM) associated gene products are targets of Ets2. Some of these matrix associated genes include: bone sialoprotein, osteonectin, osteocalcin and osteopontin |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ETS2 | up-regulates quantity by expression
transcriptional regulation
|
SPP1 |
0.254 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259872 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11175361 |
We demonstrated that Ets2 is capable of binding to and transactivating the OPN promoter using gel shift and transient transfection assays |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ETS2 | up-regulates quantity by expression
transcriptional regulation
|
IBSP |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259873 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11175361 |
Ets2 is expressed at high levels during the differentiation and matrix mineralization phases of MC3T3-E1 culture. In addition, several extracellular matrix (ECM) associated gene products are targets of Ets2. Some of these matrix associated genes include: bone sialoprotein, osteonectin, osteocalcin and osteopontin |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ETS2 | down-regulates 
|
Apoptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259870 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11175361 |
Ets1 and Ets2 seem to play opposing roles in apoptosis. While Ets1 seems to activate pro-apoptotic pathways, Ets2 seems to inhibit apoptosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KDM6A | down-regulates quantity by repression
transcriptional regulation
|
ETS2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260035 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29736013 |
Our findings reveal a dual role for UTX in suppressing acute myeloid leukaemia via repression of oncogenic ETS and upregulation of tumor suppressive GATA programs. several ETS transcription factors, including Elf4, Etv6, Erg, Fli1, Ets2, Spi1 and Elk3 were upregulated immediately after Utx loss in the preleukaemic phase |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETS2 | up-regulates quantity by expression
transcriptional regulation
|
BGLAP |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259875 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11175361 |
Ets2 is expressed at high levels during the differentiation and matrix mineralization phases of MC3T3-E1 culture. In addition, several extracellular matrix (ECM) associated gene products are targets of Ets2. Some of these matrix associated genes include: bone sialoprotein, osteonectin, osteocalcin and osteopontin |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ETS2 | up-regulates 
|
Macrophage_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259871 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11175361 |
the constitutive expression of ets2 in myeloblast leukemic cells induces their differentiation to macrophages |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ETS2
- 
- 