+ |
PRKCA | down-regulates activity
phosphorylation
|
TACSTD2 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273821 |
Ser322 |
GELRKEPsL |
Homo sapiens |
HCT-116 Cell |
pmid |
sentence |
31177095 |
Analyses using HCT116 cells expressing WT Trop-2 (HCT116/WT) or Trop-2 alanine-substituted at Ser-303 (HCT116/S303A) or Ser-322 (HCT116/S322A) revealed that Trop-2 is phosphorylated at Ser-322. sing protein kinase C (PKC) inhibitors and PKC-specific siRNAs, we found that PKCα and PKCδ are responsible for Trop-2 phosphorylation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PRKCD | down-regulates activity
phosphorylation
|
TACSTD2 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273820 |
Ser322 |
GELRKEPsL |
Homo sapiens |
HCT-116 Cell |
pmid |
sentence |
31177095 |
Analyses using HCT116 cells expressing WT Trop-2 (HCT116/WT) or Trop-2 alanine-substituted at Ser-303 (HCT116/S303A) or Ser-322 (HCT116/S322A) revealed that Trop-2 is phosphorylated at Ser-322. sing protein kinase C (PKC) inhibitors and PKC-specific siRNAs, we found that PKCα and PKCδ are responsible for Trop-2 phosphorylation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
TACSTD2 | up-regulates quantity
binding
|
CLDN7 |
0.403 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273822 |
|
|
Homo sapiens |
HCT-116 Cell |
pmid |
sentence |
31177095 |
In summary, our findings provide evidence that Trop-2 is phosphorylated at Ser-322 by PKCα/δ and that this phosphorylation enhances cell motility and decreases claudin-7 localization to cellular borders. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |