| + |
TACSTD2 | up-regulates quantity 
binding
|
CLDN7 |
0.403 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273822 |
|
|
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 31177095 |
In summary, our findings provide evidence that Trop-2 is phosphorylated at Ser-322 by PKCα/δ and that this phosphorylation enhances cell motility and decreases claudin-7 localization to cellular borders. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTBP1 | down-regulates quantity by repression 
transcriptional regulation
|
CLDN7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254105 |
|
|
Homo sapiens |
MDA-MB-468 Cell |
| pmid |
sentence |
| 19277896 |
ChIP assays revealed that SNAI1P is recruited on the CLDN7 gene promoter along with the co-repressor CtBP1 and the effector HDAC1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SNAI1 | down-regulates quantity by repression 
transcriptional regulation
|
CLDN7 |
0.417 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254104 |
|
|
Homo sapiens |
MDA-MB-468 Cell |
| pmid |
sentence |
| 19277896 |
We propose that CtBP1 is recruited by SNAI1P at the CLDN7 gene promoter indirectly through another yet to be identified protein. Based on our observations, we propose a model for SNAI1P-mediated down regulation of human CLDN7 gene expression by chromatin remodeling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HDAC1 | down-regulates quantity by repression
transcriptional regulation
|
CLDN7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254106 |
|
|
Homo sapiens |
MDA-MB-468 Cell |
| pmid |
sentence |
| 19277896 |
ChIP assays revealed that SNAI1P is recruited on the CLDN7 gene promoter along with the co-repressor CtBP1 and the effector HDAC1.|These data further suggest that HDAC1 is involved in the SNAI1P-mediated repression of the human CLDN7 gene promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CLDN7
- 
- 