Relation Results

Summary

Name H2AZ1
Full Name Histone H2A.Z
Synonyms H2A/z | H2AZ
Primary ID P0C0S5
Links - -
Type protein
Relations 4
Function Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessib ...
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Type: Score: Layout: SPV 
0.20.20.20.2DZIP3H2AZ1SLBPZNHIT1Nucleosome_H2A.Z.1 variant

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ DZIP3up-regulates activity img/direct-activation.png monoubiquitination H2AZ1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271748 Lys121 IHKSLIGkKGQQKTV Homo sapiens
pmid sentence
 2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TLR activation. H2A monoubiquitination acts to prevent FACT recruitment at the transcriptional promoter region, blocking RNA polymerase II release at the early stage of elongation.
Publications: 1 Organism: Homo Sapiens
+ SLBPup-regulates quantity by expression img/direct-activation.png translation regulation H2AZ1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265408 Homo sapiens U2-OS Cell
pmid sentence
Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cytoplasm, where SLBP participates in translation of the histone mRNA|We used radiolabeled probes generated by PCR targeting the open reading frame (ORF) to detect histones H2A, H2B, H3, H4, and H1 and used 7SK snRNA as a loading control (Fig. 2A). The abundance of histone H2A, H2B, H3, and H4 mRNAs is reduced to 37% to 70% of control levels in the SLBP knockdown cells when compared to the C2 control.
Publications: 1 Organism: Homo Sapiens
+ ZNHIT1 img/unknown.png H2AZ1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-165610 Homo sapiens
pmid sentence
The chromatin-remodelling complex snf2-related cbp activator protein (srcap) regulates chromatin structure in yeast by modulating the exchange of histone h2a for the h2a.z variant. We also show that p18hamlet is required for h2a.z accumulation into this genomic region and for subsequent muscle gene transcriptional activation.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ H2AZ1form complex img/form-complex.png binding Nucleosome_H2A.Z.1 variant 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263715 in vitro
pmid sentence
In the nucleosome, two of each of the histones H2A, H2B, H3 and H4 form the histone octamer and about 145–147 base pairs of DNA are wrapped around it . The histone H2A.Z variant is widely conserved among eukaryotes. Two isoforms, H2A.Z.1 and H2A.Z.2, have been identified in vertebrates and may have distinct functions in cell growth and gene expression. However, no structural differences between H2A.Z.1 and H2A.Z.2 have been reported. In the present study, the crystal structures of nucleosomes containing human H2A.Z.1 and H2A.Z.2 were determined.
Publications: 1 Organism: In Vitro
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