| + |
CLU | up-regulates activity 
binding
|
SCF-betaTRCP |
0.318 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271429 |
|
|
Homo sapiens |
LNCaP Cell |
| pmid |
sentence |
| 20068069 |
CLU-2 is a ubiquitin binding protein (UBP) that enhances proteasome activity. sCLU promotes degradation of COMMD1. sCLU interacts with the SCF-βTrCP E3 ligase complex, serving as a scaffolding chaperone to form a multimeric protein complex that facilitates COMMD1 and I-κB ubiquitination and proteasomal degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GDNF | up-regulates quantity by expression 
transcriptional regulation
|
CLU |
0.265 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252187 |
|
|
Rattus norvegicus |
Neural Stem Cell |
| pmid |
sentence |
| 15212950 |
We characterize the network of 43 genes induced by GDNF overproduction of neuronal progenitor cells (ST14A), which mainly regulate migration and differentiation of neuronal progenitor cells.Laminin, Mpl3, Alcam, Bin1, Id1, Id2, Id3, neuregulin1, the ephrinB2-receptor, neuritin, focal adhesion kinase (FAK), Tc10, Pdpk1, clusterin, GTP-cyclooxygenase1, and follistatin are genes up-regulated by GDNF overexpression. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
CLU | up-regulates quantity
binding
|
LRP2 |
0.578 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265256 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 32332780 |
Our results demonstrate that circulating ApoJ is retained in muscle via LRP2 and that LRP2 signaling could play a role in the maintenance of ApoJ homeostasis in circulation, at least in part. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MYBL2 | up-regulates quantity by expression
transcriptional regulation
|
CLU |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269800 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10770937 |
Here we show that the human ApoJ/Clusterin gene contains a Myb binding site in its 5' flanking region, which interacts with bacterially synthesized B-MYB protein and mediates B-MYB-dependent transactivation of the ApoJ/Clusterin promoter in transient transfection assays. Endogenous ApoJ/Clusterin expression is induced in mammalian cell lines following transient transfection of a B-MYB cDNA. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
CLU | down-regulates quantity by destabilization 
binding
|
IKBKB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271433 |
|
|
Homo sapiens |
LNCaP Cell |
| pmid |
sentence |
| 20068069 |
CLU-2 is a ubiquitin binding protein (UBP) that enhances proteasome activity. sCLU promotes degradation of COMMD1. sCLU interacts with the SCF-βTrCP E3 ligase complex, serving as a scaffolding chaperone to form a multimeric protein complex that facilitates COMMD1 and I-κB ubiquitination and proteasomal degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SYVN1 | down-regulates quantity by destabilization
polyubiquitination
|
CLU |
0.325 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272629 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 17451556 |
We also report that the ER-associated ubiquitin ligase Hrd1/synoviolin can interact with, and ubiquitinate clusterin. The fact that cleaved endogenous clusterin appears, under certain conditions, to be subject to polyubiquitination (Figure 2C) and proteasomal degradation (1, 2) strongly suggests that it passed through the secretory pathway before reaching the cytosol. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
CLU | down-regulates quantity by destabilization
binding
|
COMMD1 |
0.402 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271432 |
|
|
Homo sapiens |
LNCaP Cell |
| pmid |
sentence |
| 20068069 |
CLU-2 is a ubiquitin binding protein (UBP) that enhances proteasome activity. sCLU promotes degradation of COMMD1. sCLU interacts with the SCF-βTrCP E3 ligase complex, serving as a scaffolding chaperone to form a multimeric protein complex that facilitates COMMD1 and I-κB ubiquitination and proteasomal degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CLU
- 
- 