| + |
CREB1 | up-regulates quantity by expression 
transcriptional regulation
|
CHGA |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254276 |
|
|
Homo sapiens |
AGS Cell |
| pmid |
sentence |
| 12456801 |
Recently, binding of specific protein 1 (Sp1) and cAMP response element binding protein (CREB) to a GC-rich element at -92/-62 has been identified as a critical step in gastrin-dependent regulation of the chromogranin A (CgA) gene in gastric epithelial cells. Here we demonstrate that binding of early growth response protein 1 (Egr-1) to the distal part of the -92/-62 site is also required for gastrin-dependent CgA transactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHGA | up-regulates 
|
Peptide_hormone_processing |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254275 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12456801 |
CgA was initially identified as the major soluble matrix protein of secretory vesicles formed in neuroendocrine cells. Its functions include modulation of secretory granule stability, prohormone processing, and regulation of peptide sorting into secretory pathways |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
EGR1 | up-regulates quantity by expression
transcriptional regulation
|
CHGA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254265 |
|
|
Homo sapiens |
AGS Cell |
| pmid |
sentence |
| 12456801 |
Recently, binding of specific protein 1 (Sp1) and cAMP response element binding protein (CREB) to a GC-rich element at -92/-62 has been identified as a critical step in gastrin-dependent regulation of the chromogranin A (CgA) gene in gastric epithelial cells. Here we demonstrate that binding of early growth response protein 1 (Egr-1) to the distal part of the -92/-62 site is also required for gastrin-dependent CgA transactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHGA | up-regulates
|
Secretory_granule_organization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254274 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12456801 |
CgA was initially identified as the major soluble matrix protein of secretory vesicles formed in neuroendocrine cells. Its functions include modulation of secretory granule stability, prohormone processing, and regulation of peptide sorting into secretory pathways |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
CHGA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254273 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12456801 |
Recently, binding of specific protein 1 (Sp1) and cAMP response element binding protein (CREB) to a GC-rich element at -92/-62 has been identified as a critical step in gastrin-dependent regulation of the chromogranin A (CgA) gene in gastric epithelial cells. Here we demonstrate that binding of early growth response protein 1 (Egr-1) to the distal part of the -92/-62 site is also required for gastrin-dependent CgA transactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CHGA
- 
- 