| + |
CSNK1A1 | up-regulates 
phosphorylation
|
CREB1 |
0.318 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-64258 |
Ser100 |
ESEDSQEsVDSVTDS |
Homo sapiens |
|
| pmid |
sentence |
| 9931297 |
Ser108, ser111 and ser114, located in a region matching the consensus sequence for the casein kinase ii target, were required.These results strongly suggest that the casein kinase ii target region is involved in cell cycle-regulated phosphorylation of the creb protein and also in transcriptional enhancement. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-64250 |
Ser94 |
QISTIAEsEDSQESV |
Homo sapiens |
|
| pmid |
sentence |
| 9931297 |
Ser108, ser111 and ser114, located in a region matching the consensus sequence for the casein kinase ii target, were required.These results strongly suggest that the casein kinase ii target region is involved in cell cycle-regulated phosphorylation of the creb protein and also in transcriptional enhancement. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling |
| + |
ATR | down-regulates 
phosphorylation
|
CREB1 |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124060 |
Ser107 |
SVDSVTDsQKRREIL |
Homo sapiens |
|
| pmid |
sentence |
| 15073328 |
Atm phosphorylated creb in vitro and in vivo in response to ionizing radiation (ir) and h(2)o(2) on a stress-inducible domain. Ir-induced phosphorylation of creb correlated with a decrease in creb transactivation potential and reduced interaction between creb and its transcriptional coactivator, creb-binding protein (cbp). A creb mutant containing ala substitutions at atm phosphorylation sites displayed enhanced transactivation potentialit is, therefore, likely that atm and atr regulate creb phosphorylation collectively in response to stress stimuli. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
ATM | down-regulates
phosphorylation
|
CREB1 |
0.538 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124047 |
Ser107 |
SVDSVTDsQKRREIL |
Homo sapiens |
|
| pmid |
sentence |
| 15073328 |
Atm phosphorylated creb in vitro and in vivo in response to ionizing radiation (ir) and h(2)o(2) on a stress-inducible domain. Ir-induced phosphorylation of creb correlated with a decrease in creb transactivation potential and reduced interaction between creb and its transcriptional coactivator, creb-binding protein (cbp). A creb mutant containing ala substitutions at atm phosphorylation sites displayed enhanced transactivation potential, |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124051 |
Thr100 |
LKRLFSGtQISTIAE |
Homo sapiens |
|
| pmid |
sentence |
| 15073328 |
Individual ala substitutions at thr-100, ser-111, or ser-121 inhibited atm-catalyzed phosphate incorporationatm phosphorylated creb in vitro and in vivo in response to ionizing radiation (ir) and h(2)o(2) on a stress-inducible domain. Ir-induced phosphorylation of creb correlated with a decrease in creb transactivation potential and reduced interaction between creb and its transcriptional coactivator, creb-binding protein (cbp) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
MAPKAPK2 | up-regulates activity
phosphorylation
|
CREB1 |
0.679 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-44384 |
Ser119 |
EILSRRPsYRKILND |
Homo sapiens |
|
| pmid |
sentence |
| 8887554 |
We show that mapkap kinase-2 phosphorylates creb at ser133 in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166619 |
Ser119 |
EILSRRPsYRKILND |
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
Neverthless, some transcription factors, such as e47, er81, srf and creb are also phosphorylated by mk2. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling, P38 Signaling |
| + |
CAMK4 | up-regulates
phosphorylation
|
CREB1 |
0.698 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153940 |
Ser119 |
EILSRRPsYRKILND |
Homo sapiens |
|
| pmid |
sentence |
| 17389598 |
Pka, ca2+-calmodulin-dependent kinase iv (camkiv), msk, p70s6k and rsk phosphorylate creb. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
TSSK4 | up-regulates
phosphorylation
|
CREB1 |
0.597 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-138289 |
Ser119 |
EILSRRPsYRKILND |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15964553 |
Tssk5, a novel member of the testis-specific serine/threonine kinase family, phosphorylates creb at ser-133, and stimulates the cre/creb responsive pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6KA5 | up-regulates
phosphorylation
|
CREB1 |
0.721 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-59458 |
Ser119 |
EILSRRPsYRKILND |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9687510 |
Msk1 is localized in the nucleus of unstimulated or stimulated cells, and phosphorylates creb at ser133_ .MSK1 Is activated in vitro by mapk2/erk2 or sapk2/p38. Endogenous msk1 is activated in 293 cells by either growth factor/phorbol ester stimulation, or by exposure to uv radiation, and oxidative and chemical stres msk was the kinase responsible for phosphorylation of the transcription factor creb in response to tcr stimulation. Pka, ca2+-calmodulin-dependent kinase iv (camkiv), msk, p70s6k and rsk phosphorylate creb. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis, Malignant Melanoma, P38 Signaling |
| + |
PKA | up-regulates activity
phosphorylation
|
CREB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263653 |
Ser119 |
EILSRRPsYRKILND |
Homo sapiens |
|
| pmid |
sentence |
| 8386317 |
CREB is phosphorylated on Ser133 by PKA (protein kinase A), promoting the recruitment of the co-activator proteins CBP (CREB-binding protein) and p300; this has been proposed to increase the transcription of CREB-dependent genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Dopaminergic Synapse, FLT3-ITD signaling, GABAergic synapse , Oxytocin signaling, Thyroid Hormone Metabolism |
| + |
AKT1 | up-regulates activity
phosphorylation
|
CREB1 |
0.761 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252549 |
Ser119 |
EILSRRPsYRKILND |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9829964 |
When overexpressed in serum-stimulated cells, Akt/PKB potently induced Ser-133 phosphorylation of CREB and promoted recruitment of CBP. Correspondingly, Akt/PKB stimulated target gene expression via CREB in a phospho(Ser-133)-dependent manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis, FLT3-ITD signaling, Glioblastoma Multiforme |
| + |
MAPKAPK2 | up-regulates
phosphorylation
|
CREB1 |
0.679 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153944 |
Ser119 |
EILSRRPsYRKILND |
Homo sapiens |
|
| pmid |
sentence |
| 17389598 |
Neverthless, some transcription factors, such as e47, er81, srf and creb are also phosphorylated by mk2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling, P38 Signaling |
| + |
AKT3 | up-regulates
phosphorylation
|
CREB1 |
0.475 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62257 |
Ser119 |
EILSRRPsYRKILND |
Homo sapiens |
|
| pmid |
sentence |
| 9829964 |
When overexpressed in serum-stimulated cells, akt/pkb potently induced ser-133 phosphorylation of creb and promoted recruitment of cbp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6KA4 | up-regulates
phosphorylation
|
CREB1 |
0.588 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157158 |
Ser119 |
EILSRRPsYRKILND |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 17668895 |
Msk1 and msk2 directly phosphorilate and activete transcription factors such as creb1, atf1 msk was the kinase responsible for phosphorylation of the transcription factor creb in response to tcr stimulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT | up-regulates activity
phosphorylation
|
CREB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251474 |
Ser119 |
EILSRRPsYRKILND |
Homo sapiens |
|
| pmid |
sentence |
| 9829964 |
The nuclear factor CREB stimulates the expression of cellular genes following its protein kinase A-mediated phosphorylation at Ser-133. Ser-133 phosphorylation, in turn, activates target gene expression by promoting recruitment of the co-activator CBP. |When overexpressed in serum-stimulated cells, Akt/PKB potently induced Ser-133 phosphorylation of CREB and promoted recruitment of CBP. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-247992 |
Ser119 |
EILSRRPsYRKILND |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9829964 |
When overexpressed in serum-stimulated cells, Akt/PKB potently induced Ser-133 phosphorylation of CREB and promoted recruitment of CBP. Correspondingly, Akt/PKB stimulated target gene expression via CREB in a phospho(Ser-133)-dependent manner. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling, COVID-19 Causal Network, FLT3-ITD signaling, Glioblastoma Multiforme, Inhibition of Apoptosis, Malignant Melanoma, PI3K/AKT Signaling, Thyroid Hormone Metabolism |
| + |
RPS6KA3 | up-regulates activity
phosphorylation
|
CREB1 |
0.716 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248951 |
Ser119 |
EILSRRPsYRKILND |
Homo sapiens |
|
| pmid |
sentence |
| 8688081 |
MAPK activates CREB kinase, which in turn phosphorylates and activates CREB. Purification, sequencing, and biochemical characterization of CREB kinase revealed that it is identical to a member of the pp90(RSK) family, RSK2. RSK2 was shown to mediate growth factor induction of CREB serine-133 phosphorylation both in vitro and in vivo. These findings identify a cellular function for RSK2 and define a mechanism whereby growth factor signals mediated by RAS and MAPK are transmitted to the nucleus to activate gene expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6K | up-regulates activity
phosphorylation
|
CREB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252782 |
Ser119 |
EILSRRPsYRKILND |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 10558990 |
The rsks phosphorylate the trascription factor creb at serine 133 to promote cell survival. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling, PI3K/AKT Signaling |
| + |
CAMK4 | up-regulates activity
phosphorylation
|
CREB1 |
0.698 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102722 |
Ser119 |
EILSRRPsYRKILND |
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 12835716 |
Pka, ca2+-calmodulin-dependent kinase iv (camkiv), msk, p70s6k and rsk phosphorylate creb. All these kinases target CREB on S133 to activate CREB. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
PTEN | down-regulates activity
dephosphorylation
|
CREB1 |
0.449 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248543 |
Ser119 |
EILSRRPsYRKILND |
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 21385900 |
Our study demonstrates that PTEN can dephosphorylate CREB at Ser133 and that PTEN protein phosphatase activity is required for CREB dephosphoryation.|Moreover, we use both in vitro and in vivo experiments to show PTEN can dephosphorylate CREB in a phosphatase-dependent manner, suggesting that CREB is a substrate of PTEN nuclear phosphatase. Loss of Pten results in an elevated RNA level of multiple CREB transcriptional targets and increased cell proliferation, which can be reversed by a nonphosphorylatable CREB mutant or knockdown of CREB. These data reveal a mechanism for PTEN modulation of CREB-mediated gene transcription and cell growth. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Glioblastoma Multiforme, Malignant Melanoma, PI3K/AKT Signaling |
| + |
PRKG1 |
phosphorylation
|
CREB1 |
0.642 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249076 |
Ser119 |
EILSRRPsYRKILND |
in vitro |
|
| pmid |
sentence |
| 11175347 |
G-kinase phosphorylated GST-CREB, albeit less efficiently than A-kinase, but GST was not phosphorylated by either kinase (Figure 5a). GST-CREB purified from bacteria was similarly phosphorylated by G-kinase, whereas GST-CREB containing a serine 133 to alanine mutation was not (Figure 5b). These results demonstrate that G-kinase can directly phosphorylate CREB on serine 133. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
AKT2 | up-regulates
phosphorylation
|
CREB1 |
0.493 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62253 |
Ser119 |
EILSRRPsYRKILND |
Homo sapiens |
|
| pmid |
sentence |
| 9829964 |
Creb is a nuclear target for activation via the growth factor-dependent ser/thr kinase akt/pkb. When overexpressed in serum-stimulated cells, akt/pkb potently induced ser-133 phosphorylation of creb and promoted recruitment of cbp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6KA1 | up-regulates activity
phosphorylation
|
CREB1 |
0.738 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-72117 |
Ser119 |
EILSRRPsYRKILND |
Homo sapiens |
|
| pmid |
sentence |
| 10558990 |
The rsks phosphorylate the trascription factor creb at serine 133 to promote cell survival. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling, FLT3-ITD signaling, Inhibition of Apoptosis |
| + |
PRKACA | up-regulates activity
phosphorylation
|
CREB1 |
0.563 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166342 |
Ser119 |
EILSRRPsYRKILND |
Rattus norvegicus |
PC-12 Cell |
| pmid |
sentence |
| 8336722 |
The degree of CREB phosphorylation, assessed with antiserum specific for CREB phosphorylated at Ser-133, correlated with the amount of PKA liberated. The time course of phosphorylation closely paralleled the nuclear entry of the catalytic subun |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-131307 |
|
|
Mus musculus |
Embryonic Cell Line |
| pmid |
sentence |
| 15568017 |
Using a combination of in vitro explant assays, mutant analysis and gene delivery into mouse embryos cultured ex vivo, we demonstrate that adenylyl cyclase signalling via PKA and its target transcription factor CREB are required for WNT-directed myogenic gene expression. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176560 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
Phosphorylation of CREB by PKA allows it to initiate the transcription of genes that contain a CRE element, two of which are PAX3 and MYF5. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255799 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15568017 |
We demonstrate that adenylyl cyclase signalling via PKA and its target transcription factor CREB are required for Wnt-directed myogenic gene expression. |
|
| Publications: |
4 |
Organism: |
Rattus Norvegicus, Mus Musculus, Homo Sapiens |
| Tissue: |
Skeletal Muscle, Myotome |
| Pathways: | COVID-19 Causal Network, WNT Signaling, WNT Signaling and Myogenesis |
| + |
GSK3B | up-regulates activity
phosphorylation
|
CREB1 |
0.683 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251233 |
Ser129 |
QKRREILsRRPSYRK |
Rattus norvegicus |
|
| pmid |
sentence |
| 12162494 |
GSK-3 can phosphorylate CREB at S129 Transactivation of CREB is significantly reduced (p ≤ 0.05) by 86% for the S129A mutant |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Adipogenesis, FLT3-ITD signaling, PI3K/AKT Signaling |
| + |
CAMK2A | down-regulates
phosphorylation
|
CREB1 |
0.576 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-117344 |
Ser142 |
RKILNDLsSDAPGVP |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 11970864 |
Phosphorylation of creb1 at ser142 and ser143 is selectively activated by ca(2+) influx;phosphorylation of ser142 and ser143, disrupts the interaction of creb with its cofactor cbp. Phosphorylation of serine 142 in creb by camkii leads to dissociation of the creb dimer. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-59137 |
Ser142 |
RKILNDLsSDAPGVP |
Homo sapiens |
|
| pmid |
sentence |
| 9668047 |
Phosphorylation of creb1 at ser142 and ser143 is selectively activated by ca(2+) influx;phosphorylation of ser142 and ser143, disrupts the interaction of creb with its cofactor cbp. Phosphorylation of serine 142 in creb by camkii leads to dissociation of the creb dimer. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-82501 |
Ser142 |
RKILNDLsSDAPGVP |
Homo sapiens |
|
| pmid |
sentence |
| 11013247 |
Phosphorylation of creb1 at ser142 and ser143 is selectively activated by ca(2+) influx;phosphorylation of ser142 and ser143, disrupts the interaction of creb with its cofactor cbp. Phosphorylation of serine 142 in creb by camkii leads to dissociation of the creb dimer. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
HIPK2 | up-regulates
phosphorylation
|
CREB1 |
0.399 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166338 |
Ser257 |
PGVVMASsPALPTQP |
Homo sapiens |
|
| pmid |
sentence |
| 20573984 |
Ere we found that homeodomain-interacting protein kinase 2 (hipk2), a dna-damage responsive nuclear kinase, is a new creb kinase for phosphorylation at ser-271 but not ser-133, and activates creb transactivation function |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rett syndrome |
| + |
CSNK1A1 | up-regulates activity
phosphorylation
|
CREB1 |
0.318 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-64254 |
Ser97 |
TIAESEDsQESVDSV |
Homo sapiens |
|
| pmid |
sentence |
| 9931297 |
Ser108, ser111 and ser114, located in a region matching the consensus sequence for the casein kinase ii target, were required.These results strongly suggest that the casein kinase ii target region is involved in cell cycle-regulated phosphorylation of the creb protein and also in transcriptional enhancement. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling |
| + |
ATM | down-regulates activity
phosphorylation
|
CREB1 |
0.538 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124043 |
Ser97 |
TIAESEDsQESVDSV |
Homo sapiens |
|
| pmid |
sentence |
| 15073328 |
Individual ala substitutions at thr-100, ser-111, or ser-121 inhibited atm-catalyzed phosphate incorporationatm phosphorylated creb in vitro and in vivophosphorylation of creb correlated with a decrease in creb transactivation potential and reduced interaction between creb and its transcriptional coactivator, creb-binding protein (cbp) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
CREB1 | down-regulates quantity by repression 
transcriptional regulation
|
SNAI1 |
0.301 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253797 |
|
|
Homo sapiens |
Aorta Thoracica |
| pmid |
sentence |
| 15955695 |
In cancer tissue, the expression levels of EAR-2, COUP-TF1, EARgamma, Snail, and Slug decrease, and aromatase expression is then up-regulated through the binding of ERRalpha to S1 and the binding of CREB1 or related factors to CREaro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREB1 | up-regulates quantity by expression 
transcriptional regulation
|
PK |
0.252 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268144 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
In fasted mammals, glucose homeostasis is maintained through induction of the camp response element-binding protein (creb) coactivator transducer of regulated creb activity 2 (torc2), which stimulates the gluconeogenic program in concert with the forkhead factor foxo1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268145 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20577053 |
In fasted mammals, glucose homeostasis is maintained through induction of the camp response element-binding protein (creb) coactivator transducer of regulated creb activity 2 (torc2), which stimulates the gluconeogenic program in concert with the forkhead factor foxo1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270285 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
In fasted mammals, glucose homeostasis is maintained through induction of the camp response element-binding protein (creb) coactivator transducer of regulated creb activity 2 (torc2), which stimulates the gluconeogenic program in concert with the forkhead factor foxo1 |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
PAX3 |
0.32 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176539 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
Chen et al. showed that phosphorylated creb is present at high levels in cells of the dermomyotome that express pax3, myod and myf5 and that this phosphorylation is critical for the induction of these genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | WNT Signaling and Myogenesis |
| + |
CREB1 | up-regulates
|
Survival |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-229777 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20660310 |
beta-catenin/CBP-driven transcription is critical for maintenance of an undifferentiated/proliferative state |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glioblastoma Multiforme, Inhibition of Apoptosis, Malignant Melanoma, PI3K/AKT Signaling, WNT Signaling |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
NR4A3 |
0.34 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157154 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 17668895 |
Phosphorylation of creb by msk has been linked to the transcription of nur77, nor1 and c-fos downstream of mapk signalling in various cell types. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
N | up-regulates quantity by expression
transcriptional regulation
|
CREB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260729 |
|
|
in vitro |
|
| pmid |
sentence |
| 14623261 |
The transcription factors c-Fos, FosB, CREB-1, and ATF2 were all activated by the addition of SARS-CoV N protein to the sample well |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
MYOD1 |
0.473 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176536 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
Chen et al. showed that phosphorylated creb is present at high levels in cells of the dermomyotome that express pax3, myod and myf5 and that this phosphorylation is critical for the induction of these genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | WNT Signaling and Myogenesis |
| + |
CREB1 | up-regulates quantity
transcriptional regulation
|
G6PC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256105 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26652733 |
Further, CRTC2 is required for the glucocorticoid-associated cooperative mRNA expression of the glucose-6-phosphatase, a rate-limiting enzyme for hepatic gluconeogenesis, by facilitating the attraction of GR and itself to its promoter region already occupied by CREB |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPB | up-regulates activity
binding
|
CREB1 (isoform 1) |
0.578 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263654 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 12773552 |
We conclude that C/EBP-β can directly bind to the N-terminal Q1 domain of CREB in addition to binding to the leucine zipper domain. The transactivation potential of full-length CREB fused to the DNA-binding domain of Gal4 was increased synergistically by calcium and cGMP, and overexpression of C/EBP-β enhanced the effect, while a dominant negative C/EBP inhibited it |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
HNF1B | up-regulates activity
binding
|
CREB1 |
0.38 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241323 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9671480 |
The mammalian two-hybrid system showed that the region aa 393 to 476 of LFB3 is involved in the interaction with CREB or ATF1. The importance of this region for mediating cAMP induction was confirmed in transient transfection assays. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREBBP | up-regulates
binding
|
CREB1 |
0.94 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62260 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9829964 |
When overexpressed in serum-stimulated cells, akt/pkb potently induced ser-133 phosphorylation of creb and promoted recruitment of cbp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
FST |
0.254 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251714 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 15130492 |
MyoD, CREB, and NFAT Mediate the Transcriptional Activation of the Follistatin Promoter Induced by TSA |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
CYP19A1 |
0.43 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253798 |
|
|
Homo sapiens |
Plant Bud |
| pmid |
sentence |
| 15955695 |
In cancer tissue, the expression levels of EAR-2, COUP-TF1, EARgamma, Snail, and Slug decrease, and aromatase expression is then up-regulated through the binding of ERRalpha to S1 and the binding of CREB1 or related factors to CREaro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
IL10 |
0.442 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254522 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10540320 |
Our data suggest that intracellular cAMP may directly affect expression of the immunoregulatory cytokine IL-10 in monocytic cells via activation of the eukaryotic transcription factors CREB-1 and ATF-1 and their binding to CRE1 and CRE4 in the upstream enhancer of the IL-10 promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MECP2 | up-regulates quantity by expression
post transcriptional regulation
|
CREB1 |
0.548 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264682 |
|
|
Mus musculus |
Hypothalamus |
| pmid |
sentence |
| 18511691 |
Interestingly, Creb1 was one of the activated MeCP2 targets that we validated by quantitative real-time RT-PCR (Fig. 1C), and using ChIP analysis we found that in vivo MeCP2 binds to the promoter region of Creb1, with significantly enhanced binding in MECP2-Tg samples compared to WT (p < 0.05) | In addition, Sst and CREB1 protein levels were increased in MECP2-Tg hypothalami compared to WT, indicating that MeCP2 indeed enhances expression of Sst and Creb1 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Rett syndrome |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
MYF5 |
0.293 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176533 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
Chen et al. showed that phosphorylated creb is present at high levels in cells of the dermomyotome that express pax3, myod and myf5 and that this phosphorylation is critical for the induction of these genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | WNT Signaling and Myogenesis |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
HES1 |
0.252 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254742 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 14614508 |
HES-1 is a direct CREB target in vivo. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Liver |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
PKM |
0.252 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-142103 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
In fasted mammals, glucose homeostasis is maintained through induction of the camp response element-binding protein (creb) coactivator transducer of regulated creb activity 2 (torc2), which stimulates the gluconeogenic program in concert with the forkhead factor foxo1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166346 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20577053 |
In fasted mammals, glucose homeostasis is maintained through induction of the camp response element-binding protein (creb) coactivator transducer of regulated creb activity 2 (torc2), which stimulates the gluconeogenic program in concert with the forkhead factor foxo1 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
MITF |
0.62 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249619 |
|
|
|
|
| pmid |
sentence |
| 10841026 |
Therefore, the molecular steps linking cAMPto melanogenesis up-regulation appear currently better elucidated. cAMP activates PKA, and PKA phosphorylates and activates CREB which, when activated, binds to the CRE domain present in the microphthalmia promoter,thereby up-regulating its transcription. |
|
| Publications: |
1 |
| Pathways: | Malignant Melanoma |
| + |
CREB1 | up-regulates
|
Synaptic_plasticity |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265773 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17584923 |
These findings, together with studies in Aplysia and Drosophila, strongly suggest that CREB is an evolutionary conserved component of the molecular cascade of events leading to memory consolidation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| Pathways: | Dopaminergic Synapse, GABAergic synapse , Oxytocin signaling, Rett syndrome |
| + |
CREB1 | up-regulates quantity
transcriptional regulation
|
G6P |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267786 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26652733 |
Further, CRTC2 is required for the glucocorticoid-associated cooperative mRNA expression of the glucose-6-phosphatase, a rate-limiting enzyme for hepatic gluconeogenesis, by facilitating the attraction of GR and itself to its promoter region already occupied by CREB |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270250 |
|
|
Pongo pygmaeus |
HeLa Cell |
| pmid |
sentence |
| 26652733 |
Further, CRTC2 is required for the glucocorticoid-associated cooperative mRNA expression of the glucose-6-phosphatase, a rate-limiting enzyme for hepatic gluconeogenesis, by facilitating the attraction of GR and itself to its promoter region already occupied by CREB |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Pongo Pygmaeus |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
MUC4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254091 |
|
|
Homo sapiens |
BxPC-3 Cell |
| pmid |
sentence |
| 19757157 |
Through promoter screening, overexpressing methods and luciferase reporter studies, we found that transcription factors CREB, Ets-1, Elk-1 and STAT1 can positively regulate MUC4 expression at the promoter and mRNA level. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREB1 | down-regulates activity
binding
|
FOXO |
0.53 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252894 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15126506 |
We provide evidence that the acetyltransferase creb-binding protein (cbp) binds foxo resulting in acetylation of foxo. This acetylation inhibits foxo transcriptional activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling, PI3K/AKT Signaling, Thyroid Hormone Metabolism |
| + |
CREB1 | down-regulates quantity by repression
transcriptional regulation
|
SNAI2 |
0.286 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253791 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15955695 |
In cancer tissue, the expression levels of EAR-2, COUP-TF1, EARgamma, Snail, and Slug decrease, and aromatase expression is then up-regulated through the binding of ERRalpha to S1 and the binding of CREB1 or related factors to CREaro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREB1 | down-regulates quantity by repression
transcriptional regulation
|
NR2F6 |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253793 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15955695 |
In cancer tissue, the expression levels of EAR-2, COUP-TF1, EARgamma, Snail, and Slug decrease, and aromatase expression is then up-regulated through the binding of ERRalpha to S1 and the binding of CREB1 or related factors to CREaro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
CEBPB |
0.578 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250573 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 14593102 |
Expression of constitutively active CREB strongly activated C/EBPbeta promoter-reporter genes, induced expression of endogenous C/EBPbeta, and caused adipogenesis in the absence of the hormonal inducers normally required |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis, FLT3-ITD signaling |
| + |
CREB1 | down-regulates quantity by repression
transcriptional regulation
|
NR2F1 |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253792 |
|
|
Homo sapiens |
Infected Cell |
| pmid |
sentence |
| 15955695 |
In cancer tissue, the expression levels of EAR-2, COUP-TF1, EARgamma, Snail, and Slug decrease, and aromatase expression is then up-regulated through the binding of ERRalpha to S1 and the binding of CREB1 or related factors to CREaro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
FOS |
0.65 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157151 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 17668895 |
Phosphorylation of creb by msk has been linked to the of nur77, nor1 and c-fos downstream of mapkin various cell types |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREB1 | up-regulates
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261288 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20660310 |
Beta-catenin/CBP-driven transcription is critical for maintenance of an undifferentiated/proliferative state |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Lung |
| Pathways: | AMPK Signaling, COVID-19 Causal Network, FLT3-ITD signaling, Glioblastoma Multiforme, Malignant Melanoma, P38 Signaling, PI3K/AKT Signaling, SARS-CoV MAPK PERTURBATION, WNT Signaling |
| + |
CREB1 | down-regulates activity
binding
|
FOXO4 |
0.313 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124711 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15126506 |
We provide evidence that the acetyltransferase creb-binding protein (cbp) binds foxo resulting in acetylation of foxo. This acetylation inhibits foxo transcriptional activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREB1 | down-regulates quantity by repression
transcriptional regulation
|
PLAT |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253732 |
|
|
Homo sapiens |
HT-1080 Cell |
| pmid |
sentence |
| 8647095 |
We suggest that the mechanism for the transcriptional down-regulation of t-PA by PMA in HT-1080 cells requires CREB-1 binding to the t-PACRE while ATF-2, by associating with the same site, plays a role in PMA-mediated induction of t-PA in HeLa cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
GDA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268968 |
|
|
|
Neuron |
| pmid |
sentence |
| 21715638 |
In addition, exposure of the neurons to BDNF increased CREB binding to the cypin promoter and, in line with these data, expression of a dominant negative form of CREB blocked BDNF-promoted increases in cypin protein levels and proximal dendrite branches. |
|
| Publications: |
1 |
| Tissue: |
Brain |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
SLC5A5 |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267137 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34751390 |
CREB recognized and bound to the promoter of SLC5A5 to facilitate its transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Thyroid Gland |
| Pathways: | Thyroid Hormone Metabolism |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
BCL2L1 |
0.369 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-140911 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16205321 |
The results showed that the nuclear pkcalpha was significantly decreased in the liver during sepsis, which was accompanied by decreases in phospho-creb content, dna-binding activity of creb, and bcl-xl expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Malignant Melanoma |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
BCL2 |
0.438 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-43927 |
|
|
Homo sapiens |
B-lymphocyte, RAMOS Cell |
| pmid |
sentence |
| 8816467 |
Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-76558 |
|
|
Rattus norvegicus |
PC-12 Cell |
| pmid |
sentence |
| 10753867 |
Creb activity by akt signaling leads to increased bcl-2 promoter activity and cell survival. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Rattus Norvegicus |
| Pathways: | COVID-19 Causal Network, FLT3-ITD signaling, Inhibition of Apoptosis, Malignant Melanoma, SARS-CoV MAPK PERTURBATION |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
PPARGC1A |
0.536 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256150 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11557984 |
CREB was found to induce expression of the gluconeogenic programme through the nuclear receptor coactivator PGC-1, which is shown here to be a direct target for CREB regulation in vivo |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | AMPK Signaling |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
GCH1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252227 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16149046 |
Constitutively active mutants of activating transcription factor 2 (ATF2) and c-Jun additionally stimulated GTP cyclohydrolase I promoter activity, but to a lesser extent than the constitutively active CREB mutant. Enzymatic reactions that require tetrahydrobiopterin as cofactor are therefore indirectly controlled by signaling cascades involving the signal-responsive transcription factors CREB, c-Jun, and ATF2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CRTC2 | up-regulates activity
binding
|
CREB1 |
0.909 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256102 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26652733 |
The cAMP-response element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) is a coactivator known to be specific to CREB and plays a central role in the glucagon-mediated activation of gluconeogenesis in the early phase of fasting |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREB1 | up-regulates quantity
transcriptional regulation
|
BDNF |
0.504 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265062 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32603820 |
Brain-derived neurotrophic factor (BDNF) is a critical molecule for learning and memory. Brain BDNF levels correlate with cognitive status. Activation of CREB facilitates the transcription of crucial proteins for activity-dependent plasticity particularly BDNF. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| Pathways: | Dopaminergic Synapse, GABAergic synapse , Rett syndrome |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
CTNNB1 |
0.468 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-76984 |
|
|
Xenopus laevis |
|
| pmid |
sentence |
| 10775268 |
Here we demonstrate that the closely related acetyltransferases p300 and cbp potentiate beta-catenin-mediated activation of the siamois promoter |
|
| Publications: |
1 |
Organism: |
Xenopus Laevis |
| Pathways: | FLT3-ITD signaling, WNT Signaling, WNT Signaling and Myogenesis |
| + |
SMAD2 | up-regulates
binding
|
CREB1 |
0.332 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-59462 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9689110 |
We demonstrate that human smad2 and smad4, two essential smad proteins involved in mediating tgf-beta transcriptional responses in endothelial and other cell types, can functionally interact with the transcriptional coactivator creb binding protein (cbp). This interaction is specific in that it requires ligand (tgf-beta) activation and is mediated by the transcriptional activation domains of the smad proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
UXT |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254092 |
|
|
Homo sapiens |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 17761951 |
The DNA response elements that control the induction of ART-27 gene expression were also characterized. The major cis-acting element corresponds to a consensus cAMP-responsive element (CRE) and binds the CRE-binding protein (CREB) as shown by EMSA and chromatin immunoprecipitation assays. Furthermore, ART-27 promoter activity is induced upon CREB overexpression. Epidermal growth factor, which activates CREB via phosphorylation, also induces ART-27 expression, whereas a reduction in CREB phosphorylation or expression blocks this induction in prostate cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
POMC |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268620 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11081181 |
Transcriptional activation of the proopiomelanocortin gene by cyclic AMP-responsive element binding protein|Further, expression of a dominant inhibitory mutant of CREB reduced cAMP stimulated transcription of the full length POMC promoter and the PTRE. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Hypophysis |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
CHGA |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254276 |
|
|
Homo sapiens |
AGS Cell |
| pmid |
sentence |
| 12456801 |
Recently, binding of specific protein 1 (Sp1) and cAMP response element binding protein (CREB) to a GC-rich element at -92/-62 has been identified as a critical step in gastrin-dependent regulation of the chromogranin A (CgA) gene in gastric epithelial cells. Here we demonstrate that binding of early growth response protein 1 (Egr-1) to the distal part of the -92/-62 site is also required for gastrin-dependent CgA transactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
PCSK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253789 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8999965 |
both CREB-1 and ATF-1 transactivate the human PC1 promoter in transient transfection experiments. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CREB1
- 
- 